Miao Dong

Linjie Fu, Xia Li, Xiuding Cai et al.

Cone Beam CT (CBCT) plays a crucial role in Adaptive Radiation Therapy (ART) by accurately providing radiation treatment when organ anatomy changes occur. However, CBCT images suffer from scatter noise and artifacts, making relying solely on CBCT for precise dose calculation and accurate tissue localization challenging. Therefore, there is a need to improve CBCT image quality and Hounsfield Unit (HU) accuracy while preserving anatomical structures. To enhance the role and application value of CBCT in ART, we propose an energy-guided diffusion model (EGDiff) and conduct experiments on a chest tumor dataset to generate synthetic CT (sCT) from CBCT. The experimental results demonstrate impressive performance with an average absolute error of 26.87$\pm$6.14 HU, a structural similarity index measurement of 0.850$\pm$0.03, a peak signal-to-noise ratio of the sCT of 19.83$\pm$1.39 dB, and a normalized cross-correlation of the sCT of 0.874$\pm$0.04. These results indicate that our method outperforms state-of-the-art unsupervised synthesis methods in accuracy and visual quality, producing superior sCT images.

Yaoyao Zhu, Xiuding Cai, Yingkai Wang et al.

Deep learning models excel in computer vision tasks but often fail to generalize to out-of-distribution (OOD) domains. Invariant Risk Minimization (IRM) aims to address OOD generalization by learning domain-invariant features. However, IRM struggles with datasets exhibiting significant diversity shifts. While data augmentation methods like Mixup and Semantic Data Augmentation (SDA) enhance diversity, they risk over-augmentation and label instability. To address these challenges, we propose a domain-shared Semantic Data Augmentation (SDA) module, a novel implementation of Variance Risk Minimization (VRM) designed to enhance dataset diversity while maintaining label consistency. We further provide a Rademacher complexity analysis, establishing a tighter generalization error bound compared to baseline methods. Extensive evaluations on OOD benchmarks, including PACS, VLCS, OfficeHome, and TerraIncognita, demonstrate consistent performance improvements over state-of-the-art domain generalization methods.