Bin Liu

Chuanbo Hu, Bin Liu, Minglei Yin et al.

Mobile applications (Apps) could expose children to inappropriate themes such as sexual content, violence, and drug use. Maturity rating offers a quick and effective method for potential users, particularly guardians, to assess the maturity levels of apps. Determining accurate maturity ratings for mobile apps is essential to protect children's health in today's saturated digital marketplace. Existing approaches to maturity rating are either inaccurate (e.g., self-reported rating by developers) or costly (e.g., manual examination). In the literature, there are few text-mining-based approaches to maturity rating. However, each app typically involves multiple modalities, namely app description in the text, and screenshots in the image. In this paper, we present a framework for determining app maturity levels that utilize multimodal large language models (MLLMs), specifically ChatGPT-4 Vision. Powered by Chain-of-Thought (CoT) reasoning, our framework systematically leverages ChatGPT-4 to process multimodal app data (i.e., textual descriptions and screenshots) and guide the MLLM model through a step-by-step reasoning pathway from initial content analysis to final maturity rating determination. As a result, through explicitly incorporating CoT reasoning, our framework enables ChatGPT to understand better and apply maturity policies to facilitate maturity rating. Experimental results indicate that the proposed method outperforms all baseline models and other fusion strategies.

Lu Wei, Yi Huang, Guosheng Yin et al.

We propose a model for diagnosing Autism spectrum disorder (ASD) using multimodal magnetic resonance imaging (MRI) data. Our approach integrates brain connectivity data from diffusion tensor imaging (DTI) and functional MRI (fMRI), employing graph neural networks (GNNs) for fused graph classification. To improve diagnostic accuracy, we introduce a loss function that maximizes inter-class and minimizes intra-class margins. We also analyze network node centrality, calculating degree, subgraph, and eigenvector centralities on a bimodal fused brain graph to identify pathological regions linked to ASD. Two non-parametric tests assess the statistical significance of these centralities between ASD patients and healthy controls. Our results reveal consistency between the tests, yet the identified regions differ significantly across centralities, suggesting distinct physiological interpretations. These findings enhance our understanding of ASD's neurobiological basis and offer new directions for clinical diagnosis.

Bin Liu, Siqi Wu, Jin Wang et al.

The discovery of drug-target interactions (DTIs) plays a crucial role in pharmaceutical development. The deep learning model achieves more accurate results in DTI prediction due to its ability to extract robust and expressive features from drug and target chemical structures. However, existing deep learning methods typically generate drug features via aggregating molecular atom representations, ignoring the chemical properties carried by motifs, i.e., substructures of the molecular graph. The atom-drug double-level molecular representation learning can not fully exploit structure information and fails to interpret the DTI mechanism from the motif perspective. In addition, sequential model-based target feature extraction either fuses limited contextual information or requires expensive computational resources. To tackle the above issues, we propose a hierarchical graph representation learning-based DTI prediction method (HiGraphDTI). Specifically, HiGraphDTI learns hierarchical drug representations from triple-level molecular graphs to thoroughly exploit chemical information embedded in atoms, motifs, and molecules. Then, an attentional feature fusion module incorporates information from different receptive fields to extract expressive target features.Last, the hierarchical attention mechanism identifies crucial molecular segments, which offers complementary views for interpreting interaction mechanisms. The experiment results not only demonstrate the superiority of HiGraphDTI to the state-of-the-art methods, but also confirm the practical ability of our model in interaction interpretation and new DTI discovery.