Mariappan S. Nadar

Darshan Thaker, Mahmoud Mostapha, Radu Miron et al.

Diffusion models have been increasingly used as strong generative priors for solving inverse problems such as super-resolution in medical imaging. However, these approaches typically utilize a diffusion prior trained at a single scale, ignoring the hierarchical scale structure of image data. In this work, we propose to decompose images into Laplacian pyramid scales and train separate diffusion priors for each frequency band. We then develop an algorithm to perform super-resolution that utilizes these priors to progressively refine reconstructions across different scales. Evaluated on brain, knee, and prostate MRI data, our approach both improves perceptual quality over baselines and reduces inference time through smaller coarse-scale networks. Our framework unifies multiscale reconstruction and diffusion priors for medical image super-resolution.

Asma Tanabene, Chaithya Giliyar Radhakrishna, Aurélien Massire et al.

Deep learning has shown great promise for MRI reconstruction from undersampled data, yet there is a lack of research on validating its performance in 3D parallel imaging acquisitions with non-Cartesian undersampling. In addition, the artifacts and the resulting image quality depend on the under-sampling pattern. To address this uncharted territory, we extend the Non-Cartesian Primal-Dual Network (NC-PDNet), a state-of-the-art unrolled neural network, to a 3D multi-coil setting. We evaluated the impact of channel-specific versus channel-agnostic training configurations and examined the effect of coil compression. Finally, we benchmark four distinct non-Cartesian undersampling patterns, with an acceleration factor of six, using the publicly available Calgary-Campinas dataset. Our results show that NC-PDNet trained on compressed data with varying input channel numbers achieves an average PSNR of 42.98 dB for 1 mm isotropic 32 channel whole-brain 3D reconstruction. With an inference time of 4.95sec and a GPU memory usage of 5.49 GB, our approach demonstrates significant potential for clinical research application.

Saikat Roy, Mahmoud Mostapha, Radu Miron et al.

Plug-and-play approaches to solving inverse problems such as restoration and super-resolution have recently benefited from Diffusion-based generative priors for natural as well as medical images. However, solutions often use the standard albeit computationally intensive route of training and inferring with the whole image on the diffusion prior. While patch-based approaches to evaluating diffusion priors in plug-and-play methods have received some interest, they remain an open area of study. In this work, we explore the feasibility of the usage of patches for training and inference of a diffusion prior on MRI images. We explore the minor adaptation necessary for artifact avoidance, the performance and the efficiency of memory usage of patch-based methods as well as the adaptability of whole image training to patch-based evaluation - evaluating across multiple plug-and-play methods, tasks and datasets.

Qiaoying Huang, Xiao Chen, Dimitris Metaxas et al.

The task of medical image segmentation commonly involves an image reconstruction step to convert acquired raw data to images before any analysis. However, noises, artifacts and loss of information due to the reconstruction process are almost inevitable, which compromises the final performance of segmentation. We present a novel learning framework that performs magnetic resonance brain image segmentation directly from k-space data. The end-to-end framework consists of a unique task-driven attention module that recurrently utilizes intermediate segmentation estimation to facilitate image-domain feature extraction from the raw data, thus closely bridging the reconstruction and the segmentation tasks. In addition, to address the challenge of manual labeling, we introduce a novel workflow to generate labeled training data for segmentation by exploiting imaging modality simulators and digital phantoms. Extensive experimental results show that the proposed method outperforms several state-of-the-art methods.