Sho Ozaki, Shizuo Kaji, Toshikazu Imae et al.
Image-generative artificial intelligence (AI) has garnered significant attention in recent years. In particular, the diffusion model, a core component of generative AI, produces high-quality images with rich diversity. In this study, we proposed a novel computed tomography (CT) reconstruction method by combining the denoising diffusion probabilistic model with iterative CT reconstruction. In sharp contrast to previous studies, we optimized the fidelity loss of CT reconstruction with respect to the latent variable of the diffusion model, instead of the image and model parameters. To suppress the changes in anatomical structures produced by the diffusion model, we shallowed the diffusion and reverse processes and fixed a set of added noises in the reverse process to make it deterministic during the inference. We demonstrated the effectiveness of the proposed method through the sparse-projection CT reconstruction of 1/10 projection data. Despite the simplicity of the implementation, the proposed method has the potential to reconstruct high-quality images while preserving the patient's anatomical structures and was found to outperform existing methods, including iterative reconstruction, iterative reconstruction with total variation, and the diffusion model alone in terms of quantitative indices such as the structural similarity index and peak signal-to-noise ratio. We also explored further sparse-projection CT reconstruction using 1/20 projection data with the same trained diffusion model. As the number of iterations increased, the image quality improved comparable to that of 1/10 sparse-projection CT reconstruction. In principle, this method can be widely applied not only to CT but also to other imaging modalities.