Lei Ma

Yiming Liang, Tianyu Zheng, Xinrun Du et al. · tsinghua

Instruction tuning enhances large language models (LLMs) to follow human instructions across diverse tasks, relying on high-quality datasets to guide behavior. However, these datasets, whether manually curated or synthetically generated, are often narrowly focused and misaligned with the broad distributions captured during pre-training, limiting LLM generalization and effective use of pre-trained knowledge. We propose Aligning Instruction Tuning with Pre-training (AITP), a method that bridges this gap by identifying coverage shortfalls in instruction-tuning datasets and rewriting underrepresented pre-training data into high-quality instruction-response pairs. This approach enriches dataset diversity while preserving task-specific objectives. Evaluations on three fully open LLMs across eight benchmarks demonstrate consistent performance improvements with AITP. Ablations highlight the benefits of adaptive data selection, controlled rewriting, and balanced integration, emphasizing the importance of aligning instruction tuning with pre-training distributions to unlock the full potential of LLMs.

Zongrui Ji, Zhiming Cui, Na Li et al.

Background:Accurate tooth segmentation from cone beam computed tomography (CBCT) images is crucial for digital dentistry but remains challenging in cases of interdental adhesions, which cause severe anatomical shape distortion. Methods: To address this, we propose a deep learning framework that integrates semantic and shape awareness for shape-preserving segmentation. Our method introduces a target-tooth-centroid prompted multi-label learning strategy to model semantic relationships between teeth, reducing shape ambiguity. Additionally, a tooth-shape-aware learning mechanism explicitly enforces morphological constraints to preserve boundary integrity. These components are unified via multi-task learning, jointly optimizing segmentation and shape preservation. Results: Extensive evaluations on internal and external datasets demonstrate that our approach significantly outperforms existing methods. Conclusions: Our approach effectively mitigates shape distortions and providing anatomically faithful tooth boundaries.