Ziqiao Weng

Ziqiao Weng, Jiancheng Yang, Dongnan Liu et al.

Accurate segmentation of pulmonary airways and vessels is crucial for the diagnosis and treatment of pulmonary diseases. However, current deep learning approaches suffer from disconnectivity issues that hinder their clinical usefulness. To address this challenge, we propose a post-processing approach that leverages a data-driven method to repair the topology of disconnected pulmonary tubular structures. Our approach formulates the problem as a keypoint detection task, where a neural network is trained to predict keypoints that can bridge disconnected components. We use a training data synthesis pipeline that generates disconnected data from complete pulmonary structures. Moreover, the new Pulmonary Tree Repairing (PTR) dataset is publicly available, which comprises 800 complete 3D models of pulmonary airways, arteries, and veins, as well as the synthetic disconnected data. Our code and data are available at https://github.com/M3DV/pulmonary-tree-repairing.

Kangxian Xie, Jiancheng Yang, Donglai Wei et al.

Pulmonary diseases rank prominently among the principal causes of death worldwide. Curing them will require, among other things, a better understanding of the complex 3D tree-shaped structures within the pulmonary system, such as airways, arteries, and veins. Traditional approaches using high-resolution image stacks and standard CNNs on dense voxel grids face challenges in computational efficiency, limited resolution, local context, and inadequate preservation of shape topology. Our method addresses these issues by shifting from dense voxel to sparse point representation, offering better memory efficiency and global context utilization. However, the inherent sparsity in point representation can lead to a loss of crucial connectivity in tree-shaped structures. To mitigate this, we introduce graph learning on skeletonized structures, incorporating differentiable feature fusion for improved topology and long-distance context capture. Furthermore, we employ an implicit function for efficient conversion of sparse representations into dense reconstructions end-to-end. The proposed method not only delivers state-of-the-art performance in labeling accuracy, both overall and at key locations, but also enables efficient inference and the generation of closed surface shapes. Addressing data scarcity in this field, we have also curated a comprehensive dataset to validate our approach. Data and code are available at \url{https://github.com/M3DV/pulmonary-tree-labeling}.

Yuanhuiyi Lyu, Kaiyu Lei, Ziqiao Weng et al.

Reasoning-based text-to-image (T2I) generation requires models to interpret complex prompts accurately. Existing reasoning frameworks can be broadly categorized into two types: (1) Text-Only Reasoning, which is computationally efficient but lacks access to visual context, often resulting in the omission of critical spatial and visual elements; and (2) Text-Image Interleaved Reasoning, which leverages a T2I generator to provide visual references during the reasoning process. While this approach enhances visual grounding, it incurs substantial computational costs and constrains the reasoning capacity of MLLMs to the representational limitations of the generator. To this end, we propose StruVis, a novel framework that enhances T2I generation through Thinking with Structured Vision. Instead of relying on intermediate image generation, StruVis employs text-based structured visual representations as intermediate reasoning states, thereby enabling the MLLM to effectively "perceive" visual structure within a purely text-based reasoning process. Powered by this, the reasoning potential for T2I generation of the MLLM is unlocked through structured-vision-guided reasoning. Additionally, as a generator-agnostic reasoning framework, our proposed StruVis can be seamlessly integrated with diverse T2I generators and efficiently enhance their performance in reasoning-based T2I generation. Extensive experiments demonstrate that StruVis achieves significant performance improvements on reasoning-based T2I benchmarks, e.g., a 4.61% gain on T2I-ReasonBench and a 4% gain on WISE.

Zihao Dongfang, Xu Zheng, Ziqiao Weng et al.

The 180x360 omnidirectional field of view captured by 360-degree cameras enables their use in a wide range of applications such as embodied AI and virtual reality. Although recent advances in multimodal large language models (MLLMs) have shown promise in visual-spatial reasoning, most studies focus on standard pinhole-view images, leaving omnidirectional perception largely unexplored. In this paper, we ask: Are MLLMs ready for omnidirectional spatial reasoning? To investigate this, we introduce OSR-Bench, the first benchmark specifically designed for this setting. OSR-Bench includes over 153,000 diverse question-answer pairs grounded in high-fidelity panoramic indoor scene maps. It covers key reasoning types including object counting, relative distance, and direction. We also propose a negative sampling strategy that inserts non-existent objects into prompts to evaluate hallucination and grounding robustness. For fine-grained analysis, we design a two-stage evaluation framework assessing both cognitive map generation and QA accuracy using rotation-invariant matching and a combination of rule-based and LLM-based metrics. We evaluate eight state-of-the-art MLLMs, including GPT-4o, Gemini 1.5 Pro, and leading open-source models under zero-shot settings. Results show that current models struggle with spatial reasoning in panoramic contexts, highlighting the need for more perceptually grounded MLLMs. OSR-Bench and code will be released at: https://huggingface.co/datasets/UUUserna/OSR-Bench

Xu Zheng, Chenfei Liao, Ziqiao Weng et al.

Omnidirectional vision, using 360-degree vision to understand the environment, has become increasingly critical across domains like robotics, industrial inspection, and environmental monitoring. Compared to traditional pinhole vision, omnidirectional vision provides holistic environmental awareness, significantly enhancing the completeness of scene perception and the reliability of decision-making. However, foundational research in this area has historically lagged behind traditional pinhole vision. This talk presents an emerging trend in the embodied AI era: the rapid development of omnidirectional vision, driven by growing industrial demand and academic interest. We highlight recent breakthroughs in omnidirectional generation, omnidirectional perception, omnidirectional understanding, and related datasets. Drawing on insights from both academia and industry, we propose an ideal panoramic system architecture in the embodied AI era, PANORAMA, which consists of four key subsystems. Moreover, we offer in-depth opinions related to emerging trends and cross-community impacts at the intersection of panoramic vision and embodied AI, along with the future roadmap and open challenges. This overview synthesizes state-of-the-art advancements and outlines challenges and opportunities for future research in building robust, general-purpose omnidirectional AI systems in the embodied AI era.

Ziqiao Weng, Weidong Cai, Bo Zhou

Autism Spectrum Disorder (ASD) is a neurodevelopmental disorder impacting social and behavioral development. Resting-state fMRI, a non-invasive tool for capturing brain connectivity patterns, aids in early ASD diagnosis and differentiation from typical controls (TC). However, previous methods, which rely on either mean time series or full 4D data, are limited by a lack of spatial information or by high computational costs. This underscores the need for an efficient solution that preserves both spatial and temporal information. In this paper, we propose a novel, simple, and efficient spatial-temporal-omics learning framework designed to efficiently extract spatio-temporal features from fMRI for ASD classification. Our approach addresses these limitations by utilizing 3D time-domain derivatives as the spatial-temporal inter-voxel omics, which preserve full spatial resolution while capturing diverse statistical characteristics of the time series at each voxel. Meanwhile, functional connectivity features serve as the spatial-temporal inter-regional omics, capturing correlations across brain regions. Extensive experiments and ablation studies on the ABIDE dataset demonstrate that our framework significantly outperforms previous methods while maintaining computational efficiency. We believe our research offers valuable insights that will inform and advance future ASD studies, particularly in the realm of spatial-temporal-omics-based learning.

Ziqiao Weng, Yaoyu Fang, Jiahe Qian et al.

Spatial transcriptomics (ST) bridges gene expression and tissue morphology but faces clinical adoption barriers due to technical complexity and prohibitive costs. While computational methods predict gene expression from H&E-stained whole-slide images (WSIs), existing approaches often fail to capture the intricate biological heterogeneity within spots and are susceptible to morphological noise when integrating contextual information from surrounding tissue. To overcome these limitations, we propose HiFusion, a novel deep learning framework that integrates two complementary components. First, we introduce the Hierarchical Intra-Spot Modeling module that extracts fine-grained morphological representations through multi-resolution sub-patch decomposition, guided by a feature alignment loss to ensure semantic consistency across scales. Concurrently, we present the Context-aware Cross-scale Fusion module, which employs cross-attention to selectively incorporate biologically relevant regional context, thereby enhancing representational capacity. This architecture enables comprehensive modeling of both cellular-level features and tissue microenvironmental cues, which are essential for accurate gene expression prediction. Extensive experiments on two benchmark ST datasets demonstrate that HiFusion achieves state-of-the-art performance across both 2D slide-wise cross-validation and more challenging 3D sample-specific scenarios. These results underscore HiFusion's potential as a robust, accurate, and scalable solution for ST inference from routine histopathology.