Hung Chun Hsu

Hung-Chun Hsu, Bo-Jun Wu, Ming-Yi Hong et al.

Graph neural networks (GNNs) face significant challenges with class imbalance, leading to biased inference results. To address this issue in heterogeneous graphs, we propose a novel framework that combines Graph Neural Network (GNN) and Generative Adversarial Network (GAN) to enhance classification for underrepresented node classes. The framework incorporates an advanced edge generation and selection module, enabling the simultaneous creation of synthetic nodes and edges through adversarial learning. Unlike previous methods, which predominantly focus on homogeneous graphs due to the difficulty of representing heterogeneous graph structures in matrix form, this approach is specifically designed for heterogeneous data. Existing solutions often rely on pre-trained models to incorporate synthetic nodes, which can lead to optimization inconsistencies and mismatches in data representation. Our framework avoids these pitfalls by generating data that aligns closely with the inherent graph topology and attributes, ensuring a more cohesive integration. Evaluations on multiple real-world datasets demonstrate the method's superiority over baseline models, particularly in tasks focused on identifying minority node classes, with notable improvements in performance metrics such as F-score and AUC-PRC score. These findings highlight the potential of this approach for addressing critical challenges in the field.

Ting-An Yen, Hung-Chun Hsu, Pushpak Pati et al.

Deep learning-based methods are gaining traction in digital pathology, with an increasing number of publications and challenges that aim at easing the work of systematically and exhaustively analyzing tissue slides. These methods often achieve very high accuracies, at the cost of requiring large annotated datasets to train. This requirement is especially difficult to fulfill in the medical field, where expert knowledge is essential. In this paper we focus on nuclei segmentation, which generally requires experienced pathologists to annotate the nuclear areas in gigapixel histological images. We propose an algorithm for instance segmentation that uses pseudo-label segmentations generated automatically from point annotations, as a method to reduce the burden for pathologists. With the generated segmentation masks, the proposed method trains a modified version of HoVer-Net model to achieve instance segmentation. Experimental results show that the proposed method is robust to inaccuracies in point annotations and comparison with Hover-Net trained with fully annotated instance masks shows that a degradation in segmentation performance does not always imply a degradation in higher order tasks such as tissue classification.