Yiqing Liu

Renao Yan, Qiehe Sun, Cheng Jin et al. · tsinghua

In computational pathology, whole-slide image (WSI) classification presents a formidable challenge due to its gigapixel resolution and limited fine-grained annotations. Multiple-instance learning (MIL) offers a weakly supervised solution, yet refining instance-level information from bag-level labels remains challenging. While most of the conventional MIL methods use attention scores to estimate instance importance scores (IIS) which contribute to the prediction of the slide labels, these often lead to skewed attention distributions and inaccuracies in identifying crucial instances. To address these issues, we propose a new approach inspired by cooperative game theory: employing Shapley values to assess each instance's contribution, thereby improving IIS estimation. The computation of the Shapley value is then accelerated using attention, meanwhile retaining the enhanced instance identification and prioritization. We further introduce a framework for the progressive assignment of pseudo bags based on estimated IIS, encouraging more balanced attention distributions in MIL models. Our extensive experiments on CAMELYON-16, BRACS, TCGA-LUNG, and TCGA-BRCA datasets show our method's superiority over existing state-of-the-art approaches, offering enhanced interpretability and class-wise insights. Our source code is available at https://github.com/RenaoYan/PMIL.

Qiming He, Jing Li, Tian Guan et al.

Glomerular pathology is central to the diagnosis and prognosis of renal diseases, yet the heterogeneity of glomerular morphology and fine-grained lesion patterns remain challenging for current AI approaches. We present GloPath, an entity-centric foundation model trained on over one million glomeruli extracted from 14,049 renal biopsy specimens using multi-scale and multi-view self-supervised learning. GloPath addresses two major challenges in nephropathology: glomerular lesion assessment and clinicopathological insights discovery. For lesion assessment, GloPath was benchmarked across three independent cohorts on 52 tasks, including lesion recognition, grading, few-shot classification, and cross-modality diagnosis-outperforming state-of-the-art methods in 42 tasks (80.8%). In the large-scale real-world study, it achieved an ROC-AUC of 91.51% for lesion recognition, demonstrating strong robustness in routine clinical settings. For clinicopathological insights, GloPath systematically revealed statistically significant associations between glomerular morphological parameters and clinical indicators across 224 morphology-clinical variable pairs, demonstrating its capacity to connect tissue-level pathology with patient-level outcomes. Together, these results position GloPath as a scalable and interpretable platform for glomerular lesion assessment and clinicopathological discovery, representing a step toward clinically translatable AI in renal pathology.

Yiqing Liu, Hantao Yao, Wu Liu et al.

Multi-Agent Debate (MAD) is a collaborative framework in which multiple agents iteratively refine solutions through the generation of reasoning and alternating critique cycles. Current work primarily optimizes intra-round topologies and inter-round interactions separately, which still results in high token costs regardless of task complexity. This work introduces Heterogeneous Consensus-Progressive Reasoning for Efficient Multi-Agent Debate (HCP-MAD), leveraging consensus as a dynamic signal to facilitate progressive reasoning. The core motivation is that a majority of straightforward tasks can be effectively resolved via lightweight pair-agent debates, while complex tasks require expanded collaboration. Consequently, HCP-MAD employs a three-stage progressive reasoning mechanism to develop adaptive solutions across varying task complexities. Firstly, Heterogeneous Consensus Verification conducts rapid consensus verification using a pair of heterogeneous agents for early stopping. Next, the Heterogeneous Pair-Agent Debate applies an adaptive stopping criterion to dynamically terminate mutual critique of recorded reasoning traces. Finally, the unresolved tasks are addressed through Escalated Collective Voting by aggregating diverse perspectives from additional agents. Experiments across multiple benchmarks show that HCP-MAD significantly enhances accuracy while substantially reducing token costs.

Yiqing Liu, Hantao Yao, Wu Liu et al.

Majority voting is the standard for aggregating multi-agent responses into a final decision. However, traditional methods typically require all agents to complete their reasoning before aggregation begins, leading to significant computational overhead, as many responses become redundant once a majority consensus is achieved. In this work, we formulate the multi-agent voting as a reliability-aware agent scheduling problem, and propose an Efficient Majority-then-Stopping (EMS) to improve reasoning efficiency. EMS prioritizes agents based on task-aware reliability and terminates the reasoning pipeline the moment a majority is achieved from the following three critical components. Specifically, we introduce Agent Confidence Modeling (ACM) to estimate agent reliability using historical performance and semantic similarity, Adaptive Incremental Voting (AIV) to sequentially select agents with early stopping, and Individual Confidence Updating (ICU) to dynamically update the reliability of each contributing agent. Extensive evaluations across six benchmarks demonstrate that EMS consistently reduces the average number of invoked agents by 32%.

Kunning Li, Jianbin Guo, Zhaoyang Shang et al.

The emergence of Large Language Models (LLMs) within the Traditional Chinese Medicine (TCM) domain presents an urgent need to assess their clinical application capabilities. However, such evaluations are challenged by the individualized, holistic, and diverse nature of TCM's "Syndrome Differentiation and Treatment" (SDT). Existing benchmarks are confined to knowledge-based question-answering or the accuracy of syndrome differentiation, often neglecting assessment of treatment decision-making. Here, we propose a comprehensive, clinical case-based benchmark spearheaded by TCM experts, and a specialized reward model employed to quantify prescription-syndrome congruence. Data annotation follows a rigorous pipeline. This benchmark, designated TCM-BEST4SDT, encompasses four tasks, including TCM Basic Knowledge, Medical Ethics, LLM Content Safety, and SDT. The evaluation framework integrates three mechanisms, namely selected-response evaluation, judge model evaluation, and reward model evaluation. The effectiveness of TCM-BEST4SDT was corroborated through experiments on 15 mainstream LLMs, spanning both general and TCM domains. To foster the development of intelligent TCM research, TCM-BEST4SDT is now publicly available.

Yizhi Wang, Li Chen, Qiang Huang et al.

Cervical cancer remains a major malignancy, necessitating extensive and complex histopathological assessments and comprehensive support tools. Although deep learning shows promise, these models still lack accuracy and generalizability. General foundation models offer a broader reach but remain limited in capturing subspecialty-specific features and task adaptability. We introduce the Cervical Subspecialty Pathology (CerS-Path) diagnostic system, developed through two synergistic pretraining stages: self-supervised learning on approximately 190 million tissue patches from 140,000 slides to build a cervical-specific feature extractor, and multimodal enhancement with 2.5 million image-text pairs, followed by integration with multiple downstream diagnostic functions. Supporting eight diagnostic functions, including rare cancer classification and multimodal Q&A, CerS-Path surpasses prior foundation models in scope and clinical applicability. Comprehensive evaluations demonstrate a significant advance in cervical pathology, with prospective testing on 3,173 cases across five centers maintaining 99.38% screening sensitivity and excellent generalizability, highlighting its potential for subspecialty diagnostic translation and cervical cancer screening.

Jiacheng Hao, Yiqing Liu, Siqi Zeng et al.

Breast cancer is one of the most common cancers among women globally, with early diagnosis and precise classification being crucial. With the advancement of deep learning and computer vision, the automatic classification of breast tissue pathological images has emerged as a research focus. Existing methods typically rely on singular cell or tissue features and lack design considerations for morphological characteristics of challenging-to-classify categories, resulting in suboptimal classification performance. To address these problems, we proposes a novel breast cancer tissue classification model that Fused features of Edges, Cells, and Tissues (FECT), employing the ResMTUNet and an attention-based aggregator to extract and aggregate these features. Extensive testing on the BRACS dataset demonstrates that our model surpasses current advanced methods in terms of classification accuracy and F1 scores. Moreover, due to its feature fusion that aligns with the diagnostic approach of pathologists, our model exhibits interpretability and holds promise for significant roles in future clinical applications.