Jialong Zhong

Jialong Zhong, Tingwei Liu, Baokun Yue et al.

Multimodal survival analysis utilizing whole slide images (WSIs) and genomic profiles is fundamental for cancer prognosis. Recently, state-space models like Mamba have emerged as powerful tools for sequence modeling. However, translating this success to complex multimodal tasks is hindered by two critical limitations. First, conventional fusion strategies assume a static multimodal interaction strength, ignoring the fluctuating diagnostic importance of each modality across different patients and local regions. Second, the standard Mamba architecture processes tokens along predefined physical paths. This rigid scanning disrupts the semantic continuity of spatially scattered medical features and exacerbates long-range decay. To address these challenges, we introduce AdaSurvMamba as a novel adaptive framework for multimodal survival analysis. The framework features a Dual-Scale Importance-Aware Reconstruction (DSIR) module to dynamically modulate cross-modal interaction strength. It evaluates diagnostic importance at both the sequence and token levels to reconstruct the input representations. Furthermore, we propose a Semantic Aggregation Scanning (SAS) module to overcome contextual fragmentation. The SAS module dynamically reorganizes discrete tokens into semantically continuous sequences via a shared prototype pool. It explicitly modulates the state transition step size using global modality context and semantic priors to adaptively control the information absorption rate. Experiments across five TCGA cohorts demonstrate consistent gains over existing methods. Code is available at https://github.com/zjlGO/AdaSurvMamba.

Tingwei Liu, Miao Zhang, Leiye Liu et al.

Recently, the Diffusion Probabilistic Model (DPM)-based methods have achieved substantial success in the field of medical image segmentation. However, most of these methods fail to enable the diffusion model to learn edge features and non-edge features effectively and to inject them efficiently into the diffusion backbone. Additionally, the domain gap between the images features and the diffusion model features poses a great challenge to prostate segmentation. In this paper, we proposed CriDiff, a two-stage feature injecting framework with a Crisscross Injection Strategy (CIS) and a Generative Pre-train (GP) approach for prostate segmentation. The CIS maximizes the use of multi-level features by efficiently harnessing the complementarity of high and low-level features. To effectively learn multi-level of edge features and non-edge features, we proposed two parallel conditioners in the CIS: the Boundary Enhance Conditioner (BEC) and the Core Enhance Conditioner (CEC), which discriminatively model the image edge regions and non-edge regions, respectively. Moreover, the GP approach eases the inconsistency between the images features and the diffusion model without adding additional parameters. Extensive experiments on four benchmark datasets demonstrate the effectiveness of the proposed method and achieve state-of-the-art performance on four evaluation metrics.