Christopher Chiu

Silas Ruhrberg Estévez, Christopher Chiu, Mihaela van der Schaar

Modern clinical practice relies on evidence-based guidelines implemented as compact scoring systems composed of a small number of interpretable decision rules. While machine-learning models achieve strong performance, many fail to translate into routine clinical use due to misalignment with workflow constraints such as memorability, auditability, and bedside execution. We argue that this gap arises not from insufficient predictive power, but from optimizing over model classes that are incompatible with guideline deployment. Deployable guidelines often take the form of unit-weighted clinical checklists, formed by thresholding the sum of binary rules, but learning such scores requires searching an exponentially large discrete space of possible rule sets. We introduce AgentScore, which performs semantically guided optimization in this space by using LLMs to propose candidate rules and a deterministic, data-grounded verification-and-selection loop to enforce statistical validity and deployability constraints. Across eight clinical prediction tasks, AgentScore outperforms existing score-generation methods and achieves AUC comparable to more flexible interpretable models despite operating under stronger structural constraints. On two additional externally validated tasks, AgentScore achieves higher discrimination than established guideline-based scores.

Christopher Chiu, Simpson Zhang, Mihaela van der Schaar

As artificial intelligence (AI) agents are deployed across economic domains, understanding their strategic behavior and market-level impact becomes critical. This paper puts forward a groundbreaking new framework that is the first to capture the real-world economic forces that shape agentic labor markets: adverse selection, moral hazard, and reputation dynamics. Our framework encapsulates three core capabilities that successful LLM-agents will need: \textbf{metacognition} (accurate self-assessment of skills), \textbf{competitive awareness} (modeling rivals and market dynamics), and \textbf{long-horizon strategic planning}. We illustrate our framework through a tractable simulated gig economy where agentic Large Language Models (LLMs) compete for jobs, develop skills, and adapt their strategies under competitive pressure. Our simulations illustrate how LLM agents explicitly prompted with reasoning capabilities learn to strategically self-improve and demonstrate superior adaptability to changing market conditions. At the market level, our simulations reproduce classic macroeconomic phenomena found in human labor markets, while controlled experiments reveal potential AI-driven economic trends, such as rapid monopolization and systemic price deflation. This work provides a foundation to further explore the economic properties of AI-driven labour markets, and a conceptual framework to study the strategic reasoning capabilities in agents competing in the emerging economy.

Christopher Chiu, Maximilian Heil, Teresa Kim et al.

FungiCLEF 2024 addresses the fine-grained visual categorization (FGVC) of fungi species, with a focus on identifying poisonous species. This task is challenging due to the size and class imbalance of the dataset, subtle inter-class variations, and significant intra-class variability amongst samples. In this paper, we document our approach in tackling this challenge through the use of ensemble classifier heads on pre-computed image embeddings. Our team (DS@GT) demonstrate that state-of-the-art self-supervised vision models can be utilized as robust feature extractors for downstream application of computer vision tasks without the need for task-specific fine-tuning on the vision backbone. Our approach achieved the best Track 3 score (0.345), accuracy (78.4%) and macro-F1 (0.577) on the private test set in post competition evaluation. Our code is available at https://github.com/dsgt-kaggle-clef/fungiclef-2024.

Christopher Chiu, Silviu Pitis, Mihaela van der Schaar

Clinical reasoning in medicine is a hypothesis-driven process where physicians refine diagnoses from limited information through targeted history, physical examination, and diagnostic investigations. In contrast, current medical benchmarks for large language models (LLMs) primarily assess knowledge recall through single-turn questions, where complete clinical information is provided upfront. To address this gap, we introduce VivaBench, a multi-turn benchmark that evaluates sequential clinical reasoning in LLM agents. Our dataset consists of 1762 physician-curated clinical vignettes structured as interactive scenarios that simulate a (oral) examination in medical training, requiring agents to actively probe for relevant findings, select appropriate investigations, and synthesize information across multiple steps to reach a diagnosis. While current LLMs demonstrate competence in diagnosing conditions from well-described clinical presentations, their performance degrades significantly when required to navigate iterative diagnostic reasoning under uncertainty in our evaluation. Our analysis identified several failure modes that mirror common cognitive errors in clinical practice, including: (1) fixation on initial hypotheses, (2) inappropriate investigation ordering, (3) premature diagnostic closure, and (4) failing to screen for critical conditions. These patterns reveal fundamental limitations in how current LLMs reason and make decisions under uncertainty. Through VivaBench, we provide a standardized benchmark for evaluating conversational medical AI systems for real-world clinical decision support. Beyond medical applications, we contribute to the larger corpus of research on agentic AI by demonstrating how sequential reasoning trajectories can diverge in complex decision-making environments.

David E. J. Waddington, Nicholas Hindley, Neha Koonjoo et al.

MRI-guidance techniques that dynamically adapt radiation beams to follow tumor motion in real-time will lead to more accurate cancer treatments and reduced collateral healthy tissue damage. The gold-standard for reconstruction of undersampled MR data is compressed sensing (CS) which is computationally slow and limits the rate that images can be available for real-time adaptation. Here, we demonstrate the use of automated transform by manifold approximation (AUTOMAP), a generalized framework that maps raw MR signal to the target image domain, to rapidly reconstruct images from undersampled radial k-space data. The AUTOMAP neural network was trained to reconstruct images from a golden-angle radial acquisition, a benchmark for motion-sensitive imaging, on lung cancer patient data and generic images from ImageNet. Model training was subsequently augmented with motion-encoded k-space data derived from videos in the YouTube-8M dataset to encourage motion robust reconstruction. We find that AUTOMAP-reconstructed radial k-space has equivalent accuracy to CS but with much shorter processing times after initial fine-tuning on retrospectively acquired lung cancer patient data. Validation of motion-trained models with a virtual dynamic lung tumor phantom showed that the generalized motion properties learned from YouTube lead to improved target tracking accuracy. Our work shows that AUTOMAP can achieve real-time, accurate reconstruction of radial data. These findings imply that neural-network-based reconstruction is potentially superior to existing approaches for real-time image guidance applications.