Jin Ye

Ying Chen, Guoan Wang, Yuanfeng Ji et al.

Despite the progress made by multimodal large language models (MLLMs) in computational pathology, they remain limited by a predominant focus on patch-level analysis, missing essential contextual information at the whole-slide level. The lack of large-scale instruction datasets and the gigapixel scale of whole slide images (WSIs) pose significant developmental challenges. In this paper, we present SlideChat, the first vision-language assistant capable of understanding gigapixel whole-slide images, exhibiting excellent multimodal conversational capability and response complex instruction across diverse pathology scenarios. To support its development, we created SlideInstruction, the largest instruction-following dataset for WSIs consisting of 4.2K WSI captions and 176K VQA pairs with multiple categories. Furthermore, we propose SlideBench, a multimodal benchmark that incorporates captioning and VQA tasks to assess SlideChat's capabilities in varied clinical settings such as microscopy, diagnosis. Compared to both general and specialized MLLMs, SlideChat exhibits exceptional capabilities achieving state-of-the-art performance on 18 of 22 tasks. For example, it achieved an overall accuracy of 81.17% on SlideBench-VQA (TCGA), and 54.15% on SlideBench-VQA (BCNB). Our code, data, and model is publicly accessible at https://uni-medical.github.io/SlideChat.github.io.

Jin Ye, Fengchao Xiong, Jun Zhou et al.

Hyperspectral image (HSI) denoising is a crucial preprocessing step for subsequent tasks. The clean HSI usually reside in a low-dimensional subspace, which can be captured by low-rank and sparse representation, known as the physical prior of HSI. It is generally challenging to adequately use such physical properties for effective denoising while preserving image details. This paper introduces a novel iterative low-rank network (ILRNet) to address these challenges. ILRNet integrates the strengths of model-driven and data-driven approaches by embedding a rank minimization module (RMM) within a U-Net architecture. This module transforms feature maps into the wavelet domain and applies singular value thresholding (SVT) to the low-frequency components during the forward pass, leveraging the spectral low-rankness of HSIs in the feature domain. The parameter, closely related to the hyperparameter of the singular vector thresholding algorithm, is adaptively learned from the data, allowing for flexible and effective capture of low-rankness across different scenarios. Additionally, ILRNet features an iterative refinement process that adaptively combines intermediate denoised HSIs with noisy inputs. This manner ensures progressive enhancement and superior preservation of image details. Experimental results demonstrate that ILRNet achieves state-of-the-art performance in both synthetic and real-world noise removal tasks.

Jin Ye, Jingran Wang, Fengchao Xiong et al.

Hyperspectral images (HSIs) play a crucial role in remote sensing but are often degraded by complex noise patterns. Ensuring the physical property of the denoised HSIs is vital for robust HSI denoising, giving the rise of deep unfolding-based methods. However, these methods map the optimization of a physical model to a learnable network with a predefined depth, which lacks convergence guarantees. In contrast, Deep Equilibrium (DEQ) models treat the hidden layers of deep networks as the solution to a fixed-point problem and models them as infinite-depth networks, naturally consistent with the optimization. Under the framework of DEQ, we propose a Deep Equilibrium Convolutional Sparse Coding (DECSC) framework that unifies local spatial-spectral correlations, nonlocal spatial self-similarities, and global spatial consistency for robust HSI denoising. Within the convolutional sparse coding (CSC) framework, we enforce shared 2D convolutional sparse representation to ensure global spatial consistency across bands, while unshared 3D convolutional sparse representation captures local spatial-spectral details. To further exploit nonlocal self-similarities, a transformer block is embedded after the 2D CSC. Additionally, a detail enhancement module is integrated with the 3D CSC to promote image detail preservation. We formulate the proximal gradient descent of the CSC model as a fixed-point problem and transform the iterative updates into a learnable network architecture within the framework of DEQ. Experimental results demonstrate that our DECSC method achieves superior denoising performance compared to state-of-the-art methods.