Robert Turnbull

Robert Turnbull

Deep learning has been used to assist in the analysis of medical imaging. One such use is the classification of Computed Tomography (CT) scans when detecting for COVID-19 in subjects. This paper presents Cov3d, a three dimensional convolutional neural network for detecting the presence and severity of COVID19 from chest CT scans. Trained on the COV19-CT-DB dataset with human expert annotations, it achieves a macro f1 score of 0.9476 on the validation set for the task of detecting the presence of COVID19. For the task of classifying the severity of COVID19, it achieves a macro f1 score of 0.7552. Both results improve on the baseline results of the `AI-enabled Medical Image Analysis Workshop and Covid-19 Diagnosis Competition' (MIA-COV19D) in 2022.

Robert Turnbull

Improving automated analysis of medical imaging will provide clinicians more options in providing care for patients. The 2023 AI-enabled Medical Image Analysis Workshop and Covid-19 Diagnosis Competition (AI-MIA-COV19D) provides an opportunity to test and refine machine learning methods for detecting the presence and severity of COVID-19 in patients from CT scans. This paper presents version 2 of Cov3d, a deep learning model submitted in the 2022 competition. The model has been improved through a preprocessing step which segments the lungs in the CT scan and crops the input to this region. It results in a validation macro F1 score for predicting the presence of COVID-19 in the CT scans at 93.2% which is significantly above the baseline of 74\%. It gives a macro F1 score for predicting the severity of COVID-19 on the validation set for task 2 as 72.8% which is above the baseline of 38%.

Robert Turnbull, Evelyn Mannix

Purpose: The capacity to isolate and recognize individual characters from facsimile images of papyrus manuscripts yields rich opportunities for digital analysis. For this reason the `ICDAR 2023 Competition on Detection and Recognition of Greek Letters on Papyri' was held as part of the 17th International Conference on Document Analysis and Recognition. This paper discusses our submission to the competition. Methods: We used an ensemble of YOLOv8 models to detect and classify individual characters and employed two different approaches for refining the character predictions, including a transformer based DeiT approach and a ResNet-50 model trained on a large corpus of unlabelled data using SimCLR, a self-supervised learning method. Results: Our submission won the recognition challenge with a mAP of 42.2%, and was runner-up in the detection challenge with a mean average precision (mAP) of 51.4%. At the more relaxed intersection over union threshold of 0.5, we achieved the highest mean average precision and mean average recall results for both detection and classification. Conclusion: The results demonstrate the potential for these techniques for automated character recognition on historical manuscripts. We ran the prediction pipeline on more than 4,500 images from the Oxyrhynchus Papyri to illustrate the utility of our approach, and we release the results publicly in multiple formats.

Robert Turnbull, Simon Mutch

This paper outlines our submission for the 4th COV19D competition as part of the `Domain adaptation, Explainability, Fairness in AI for Medical Image Analysis' (DEF-AI-MIA) workshop at the Computer Vision and Pattern Recognition Conference (CVPR). The competition consists of two challenges. The first is to train a classifier to detect the presence of COVID-19 from over one thousand CT scans from the COV19-CT-DB database. The second challenge is to perform domain adaptation by taking the dataset from Challenge 1 and adding a small number of scans (some annotated and other not) for a different distribution. We preprocessed the CT scans to segment the lungs, and output volumes with the lungs individually and together. We then trained 3D ResNet and Swin Transformer models on these inputs. We annotated the unlabeled CT scans using an ensemble of these models and chose the high-confidence predictions as pseudo-labels for fine-tuning. This resulted in a best cross-validation mean F1 score of 93.39\% for Challenge 1 and a mean F1 score of 92.15 for Challenge 2.

Robert Turnbull, Neil D. Young, Edoardo Tescari et al.

Repetitive DNA sequences underpin genome architecture and evolutionary processes, yet they remain challenging to classify accurately. Terrier is a deep learning model designed to overcome these challenges by classifying repetitive DNA sequences using a publicly available, curated repeat sequence library trained under the RepeatMasker schema. Poor representation of taxa within repeat databases often limits the classification accuracy and reproducibility of current repeat annotation methods, limiting our understanding of repeat evolution and function. Terrier overcomes these challenges by leveraging deep learning for improved accuracy. Trained on Repbase, which includes over 100,000 repeat families -- four times more than Dfam -- Terrier maps 97.1% of Repbase sequences to RepeatMasker categories, offering the most comprehensive classification system available. When benchmarked against DeepTE, TERL, and TEclass2 in model organisms (rice, fruit flies, humans, and mice), Terrier achieved superior accuracy while classifying a broader range of sequences. Further validation in non-model amphibian, flatworm and Northern krill genomes highlights its effectiveness in improving classification in non-model species, facilitating research on repeat-driven evolution, genomic instability, and phenotypic variation.

Robert Turnbull, Emily Fitzgerald, Karen Thompson et al.

Specimen-associated biodiversity data are crucial for biological, environmental, and conservation sciences. A rate shift is needed to extract data from specimen images efficiently, moving beyond human-mediated transcription. We developed `Hespi' (HErbarium Specimen sheet PIpeline) using advanced computer vision techniques to extract pre-catalogue data from primary specimen labels on herbarium specimens. Hespi integrates two object detection models: one for detecting the components of the sheet and another for fields on the primary primary specimen label. It classifies labels as printed, typed, handwritten, or mixed and uses Optical Character Recognition (OCR) and Handwritten Text Recognition (HTR) for extraction. The text is then corrected against authoritative taxon databases and refined using a multimodal Large Language Model (LLM). Hespi accurately detects and extracts text from specimen sheets across international herbaria, and its modular design allows users to train and integrate custom models.

Robert Turnbull

Application of phylogenetic methods to textual traditions has traditionally treated all changes as equivalent even though it is widely recognized that certain types of variants were more likely to be introduced than others. While it is possible to give weights to certain changes using a maximum parsimony evaluation criterion, it is difficult to state a priori what these weights should be. Probabilistic methods, such as Bayesian phylogenetics, allow users to create categories of changes, and the transition rates for each category can be estimated as part of the analysis. This classification of types of changes in readings also allows for inspecting the probability of these categories across each branch in the resulting trees. However, classification of readings is time-consuming, as it requires categorizing each reading against every other reading at each variation unit, presenting a significant barrier to entry for this kind of analysis. This paper presents Rdgai, a software package that automates this classification task using multi-lingual large language models (LLMs). The tool allows users to easily manually classify changes in readings and then it uses these annotations in the prompt for an LLM to automatically classify the remaining reading transitions. These classifications are stored in TEI XML and ready for downstream phylogenetic analysis. This paper demonstrates the application with data an Arabic translation of the Gospels.

Ashkan Pakzad, Robert Turnbull, Simon J. Mutch et al.

Breast cancer is the most frequently diagnosed human cancer in the United States at present. Early detection is crucial for its successful treatment. X-ray mammography and digital breast tomosynthesis are currently the main methods for breast cancer screening. However, both have known limitations in terms of their sensitivity and specificity to breast cancers, while also frequently causing patient discomfort due to the requirement for breast compression. Breast computed tomography is a promising alternative, however, to obtain high-quality images, the X-ray dose needs to be sufficiently high. As the breast is highly radiosensitive, dose reduction is particularly important. Phase-contrast computed tomography (PCT) has been shown to produce higher-quality images at lower doses and has no need for breast compression. It is demonstrated in the present study that, when imaging full fresh mastectomy samples with PCT, deep learning-based image denoising can further reduce the radiation dose by a factor of 16 or more, without any loss of image quality. The image quality has been assessed both in terms of objective metrics, such as spatial resolution and contrast-to-noise ratio, as well as in an observer study by experienced medical imaging specialists and radiologists. This work was carried out in preparation for live patient PCT breast cancer imaging, initially at specialized synchrotron facilities.