Jianzhen Wu

Yunfei Xie, Juncheng Wu, Haoqin Tu et al.

Large language models (LLMs) have exhibited remarkable capabilities across various domains and tasks, pushing the boundaries of our knowledge in learning and cognition. The latest model, OpenAI's o1, stands out as the first LLM with an internalized chain-of-thought technique using reinforcement learning strategies. While it has demonstrated surprisingly strong capabilities on various general language tasks, its performance in specialized fields such as medicine remains unknown. To this end, this report provides a comprehensive exploration of o1 on different medical scenarios, examining 3 key aspects: understanding, reasoning, and multilinguality. Specifically, our evaluation encompasses 6 tasks using data from 37 medical datasets, including two newly constructed and more challenging question-answering (QA) tasks based on professional medical quizzes from the New England Journal of Medicine (NEJM) and The Lancet. These datasets offer greater clinical relevance compared to standard medical QA benchmarks such as MedQA, translating more effectively into real-world clinical utility. Our analysis of o1 suggests that the enhanced reasoning ability of LLMs may (significantly) benefit their capability to understand various medical instructions and reason through complex clinical scenarios. Notably, o1 surpasses the previous GPT-4 in accuracy by an average of 6.2% and 6.6% across 19 datasets and two newly created complex QA scenarios. But meanwhile, we identify several weaknesses in both the model capability and the existing evaluation protocols, including hallucination, inconsistent multilingual ability, and discrepant metrics for evaluation. We release our raw data and model outputs at https://ucsc-vlaa.github.io/o1_medicine/ for future research.

Xiaoke Huang, Juncheng Wu, Hui Liu et al.

Large Reasoning Models (LRMs) have introduced a new paradigm in AI by enabling models to ``think before responding" via chain-of-thought reasoning. However, the absence of open and reproducible recipes for building reasoning-centric medical LMMs hinders community-wide research, analysis, and comparison. In this paper, we present MedVLThinker, a suite of simple yet strong baselines. Our fully open recipe consists of: (1) systematic data curation for both text-only and image-text medical data, filtered according to varying levels of reasoning difficulty, and (2) two training paradigms: Supervised Fine-Tuning (SFT) on distilled reasoning traces and Reinforcement Learning with Verifiable Rewards (RLVR) based on final answer correctness. Across extensive experiments on the Qwen2.5-VL model family (3B, 7B) and six medical QA benchmarks, we find that RLVR consistently and significantly outperforms SFT. Additionally, under the RLVR framework, a key, counter-intuitive finding is that training on our curated text-only reasoning data provides a more substantial performance boost than training on multimodal image-text data. Our best open 7B model, trained using the RLVR recipe on text-only data, establishes a new state-of-the-art on existing public VQA benchmarks, surpassing all previous open-source medical LMMs. Furthermore, scaling our model to 32B achieves performance on par with the proprietary GPT-4o. We release all curated data, models, and code to provide the community with a strong, open foundation for future research in multimodal medical reasoning.

Juncheng Wu, Sheng Liu, Haoqin Tu et al.

Recent advances in reasoning-enhanced Large Language Models such as OpenAI-o1/3 and DeepSeek-R1 have significantly improved performance on complex tasks. However, the quality and transparency of their internal reasoning processes remain underexplored. This work moves beyond the final-answer accuracy and investigates step-by-step reasoning in the medical and mathematical domains by explicitly decomposing the thinking trajectories into two parts: knowledge and reasoning. Specifically, we introduce a fine-grained evaluation framework that judges: (1) the correctness of knowledge used (measured by Knowledge Index (KI)) and (2) the quality of reasoning (measured by Information Gain (InfoGain)). Using this framework, we study R1-distilled and base Qwen models trained with supervised fine-tuning (SFT) and/or reinforcement learning (RL) in the medical and math domains. Three intriguing findings emerge: (1) The general reasoning abilities in R1-distilled models do not transfer effectively to the medical domain through either SFT or RL. (2) SFT raises final-answer accuracy in both domains, but often at the cost of reasoning quality: InfoGain drops by 38.9% on average compared with untrained models; In the medical domain, however, SFT remains crucial because domain knowledge is indispensable. (3) RL enhances medical reasoning by pruning inaccurate or irrelevant knowledge from reasoning paths, thereby improving both reasoning accuracy and knowledge correctness.