Yuchen Xu

Chaoqin Huang, Zi Zeng, Aofan Jiang et al.

Rare cardiac anomalies are difficult to detect from electrocardiograms (ECGs) due to their long-tailed distribution with extremely limited case counts and demographic disparities in diagnostic performance. These limitations contribute to delayed recognition and uneven quality of care, creating an urgent need for a generalizable framework that enhances sensitivity while ensuring equity across diverse populations. In this study, we developed an AI-assisted two-stage ECG framework integrating self-supervised anomaly detection with demographic-aware representation learning. The first stage performs self-supervised anomaly detection pretraining by reconstructing masked global and local ECG signals, modeling signal trends, and predicting patient attributes to learn robust ECG representations without diagnostic labels. The pretrained model is then fine-tuned for multi-label ECG classification using asymmetric loss to better handle long-tail cardiac abnormalities, and additionally produces anomaly score maps for localization, with CPU-based optimization enabling practical deployment. Evaluated on a longitudinal cohort of over one million clinical ECGs, our method achieves an AUROC of 94.7% for rare anomalies and reduces the common-rare performance gap by 73%, while maintaining consistent diagnostic accuracy across age and sex groups. In conclusion, the proposed equity-aware AI framework demonstrates strong clinical utility, interpretable anomaly localization, and scalable performance across multiple cohorts, highlighting its potential to mitigate diagnostic disparities and advance equitable anomaly detection in biomedical signals and digital health. Source code is available at https://github.com/MediaBrain-SJTU/Rare-ECG.

Yuchen Xu, Andrew M. Thomas, Peter A. Crozier et al.

Ridge detection is a classical tool to extract curvilinear features in image processing. As such, it has great promise in applications to material science problems; specifically, for trend filtering relatively stable atom-shaped objects in image sequences, such as Transmission Electron Microscopy (TEM) videos. Standard analysis of TEM videos is limited to frame-by-frame object recognition. We instead harness temporal correlation across frames through simultaneous analysis of long image sequences, specified as a spatio-temporal image tensor. We define new ridge detection algorithms to non-parametrically estimate explicit trajectories of atomic-level object locations as a continuous function of time. Our approach is specially tailored to handle temporal analysis of objects that seemingly stochastically disappear and subsequently reappear throughout a sequence. We demonstrate that the proposed method is highly effective and efficient in simulation scenarios, and delivers notable performance improvements in TEM experiments compared to other material science benchmarks.

Aofan Jiang, Chaoqin Huang, Qing Cao et al.

Current computer-aided ECG diagnostic systems struggle with the underdetection of rare but critical cardiac anomalies due to the imbalanced nature of ECG datasets. This study introduces a novel approach using self-supervised anomaly detection pretraining to address this limitation. The anomaly detection model is specifically designed to detect and localize subtle deviations from normal cardiac patterns, capturing the nuanced details essential for accurate ECG interpretation. Validated on an extensive dataset of over one million ECG records from clinical practice, characterized by a long-tail distribution across 116 distinct categories, the anomaly detection-pretrained ECG diagnostic model has demonstrated a significant improvement in overall accuracy. Notably, our approach yielded a 94.7% AUROC, 92.2% sensitivity, and 92.5\% specificity for rare ECG types, significantly outperforming traditional methods and narrowing the performance gap with common ECG types. The integration of anomaly detection pretraining into ECG analysis represents a substantial contribution to the field, addressing the long-standing challenge of long-tail data distributions in clinical diagnostics. Furthermore, prospective validation in real-world clinical settings revealed that our AI-driven approach enhances diagnostic efficiency, precision, and completeness by 32%, 6.7%, and 11.8% respectively, when compared to standard practices. This advancement marks a pivotal step forward in the integration of AI within clinical cardiology, with particularly profound implications for emergency care, where rapid and accurate ECG interpretation is crucial. The contributions of this study not only push the boundaries of current ECG diagnostic capabilities but also lay the groundwork for more reliable and accessible cardiovascular care.

Yitao Yuan, Jianglong Nie, Tianyu Bai et al.

In-Network Collective (INC) acceleration holds immense potential for optimizing AI training and inference; however, its cross-layer nature has historically hindered investment and adoption within the open Ethernet ecosystem. To bridge this gap, we propose EPIC (Ethernet Polymorphic In-network Collective), an INC protocol specification and reference system built on the principle of "Unified Abstraction, Polymorphic Realization." EPIC introduces an abstraction compatible with standard Ethernet that aligns functional boundaries with participant roles, while offering polymorphic realizations tailored to varying hardware capabilities. We address three fundamental challenges: first, we employ a modular design that enables an evolutionary path from simple to complex implementations, allowing vendors to iterate their hardware incrementally; second, we apply formal verification methodologies to prove the correctness of all proposed polymorphic modes; and third, we develop a unified resource management model versatile enough for diverse INC scenarios. Extensive validation -- spanning model checking, packet/flow simulations, VM emulation, Tofino Testbed, and FPGA/RTL verification -- confirms EPIC's correctness, performance gain, and feasibility.

Haoyu Li, Yuchen Xu, Jiayi Chen et al.

As deep neural networks (DNNs) grow in complexity and size, the resultant increase in communication overhead during distributed training has become a significant bottleneck, challenging the scalability of distributed training systems. Existing solutions, while aiming to mitigate this bottleneck through worker-level compression and in-network aggregation, fall short due to their inability to efficiently reconcile the trade-offs between compression effectiveness and computational overhead, hindering overall performance and scalability. In this paper, we introduce a novel compression algorithm that effectively merges worker-level compression with in-network aggregation. Our solution is both homomorphic, allowing for efficient in-network aggregation without CPU/GPU processing, and lossless, ensuring no compromise on training accuracy. Theoretically optimal in compression and computational efficiency, our approach is empirically validated across diverse DNN models such as NCF, LSTM, VGG19, and BERT-base, showing up to a 6.33$\times$ improvement in aggregation throughput and a 3.74$\times$ increase in per-iteration training speed.

Aofan Jiang, Chaoqin Huang, Qing Cao et al.

The electrocardiogram (ECG) is an essential tool for diagnosing heart disease, with computer-aided systems improving diagnostic accuracy and reducing healthcare costs. Despite advancements, existing systems often miss rare cardiac anomalies that could be precursors to serious, life-threatening issues or alterations in the cardiac macro/microstructure. We address this gap by focusing on self-supervised anomaly detection (AD), training exclusively on normal ECGs to recognize deviations indicating anomalies. We introduce a novel self-supervised learning framework for ECG AD, utilizing a vast dataset of normal ECGs to autonomously detect and localize cardiac anomalies. It proposes a novel masking and restoration technique alongside a multi-scale cross-attention module, enhancing the model's ability to integrate global and local signal features. The framework emphasizes accurate localization of anomalies within ECG signals, ensuring the method's clinical relevance and reliability. To reduce the impact of individual variability, the approach further incorporates crucial patient-specific information from ECG reports, such as age and gender, thus enabling accurate identification of a broad spectrum of cardiac anomalies, including rare ones. Utilizing an extensive dataset of 478,803 ECG graphic reports from real-world clinical practice, our method has demonstrated exceptional effectiveness in AD across all tested conditions, regardless of their frequency of occurrence, significantly outperforming existing models. It achieved superior performance metrics, including an AUROC of 91.2%, an F1 score of 83.7%, a sensitivity rate of 84.2%, a specificity of 83.0%, and a precision of 75.6% with a fixed recall rate of 90%. It has also demonstrated robust localization capabilities, with an AUROC of 76.5% and a Dice coefficient of 65.3% for anomaly localization.

Jiayi Zhang, Yiming Zhang, Yuan Zheng et al.

Urban traffic optimization is critical for improving transportation efficiency and alleviating congestion, particularly in large-scale dynamic networks. Traditional methods, such as Dijkstra's and Floyd's algorithms, provide effective solutions in static settings, but they struggle with the spatial-temporal complexity of real-world traffic flows. In this work, we propose TrafficKAN-GCN, a hybrid deep learning framework combining Kolmogorov-Arnold Networks (KAN) with Graph Convolutional Networks (GCN), designed to enhance urban traffic flow optimization. By integrating KAN's adaptive nonlinear function approximation with GCN's spatial graph learning capabilities, TrafficKAN-GCN captures both complex traffic patterns and topological dependencies. We evaluate the proposed framework using real-world traffic data from the Baltimore Metropolitan area. Compared with baseline models such as MLP-GCN, standard GCN, and Transformer-based approaches, TrafficKAN-GCN achieves competitive prediction accuracy while demonstrating improved robustness in handling noisy and irregular traffic data. Our experiments further highlight the framework's ability to redistribute traffic flow, mitigate congestion, and adapt to disruptive events, such as the Francis Scott Key Bridge collapse. This study contributes to the growing body of work on hybrid graph learning for intelligent transportation systems, highlighting the potential of combining KAN and GCN for real-time traffic optimization. Future work will focus on reducing computational overhead and integrating Transformer-based temporal modeling for enhanced long-term traffic prediction. The proposed TrafficKAN-GCN framework offers a promising direction for data-driven urban mobility management, balancing predictive accuracy, robustness, and computational efficiency.

Bolun Sun, Charles Chang, Yuen Yuen Ang et al.

We introduce CAPC-CG, the Chinese Adaptive Policy Communication (Central Government) Corpus, the first open dataset of Chinese policy directives annotated with a five-color taxonomy of clear and ambiguous language categories, building on Ang's theory of adaptive policy communication. Spanning 1949-2023, this corpus includes national laws, administrative regulations, and ministerial rules issued by China's top authorities. Each document is segmented into paragraphs, producing a total of 3.3 million units. Alongside the corpus, we release comprehensive metadata, a two-round labeling framework, and a gold-standard annotation set developed by expert and trained coders. Inter-annotator agreement achieves a Fleiss's kappa of K = 0.86 on directive labels, indicating high reliability for supervised modeling. We provide baseline classification results with several large language models (LLMs), together with our annotation codebook, and describe patterns from the dataset. This release aims to support downstream tasks and multilingual NLP research in policy communication.

Yuhong Zhang, Xusheng Zhu, Yuchen Xu et al.

Electroencephalography (EEG) is a non-invasive method for measuring brain activity with high temporal resolution; however, EEG signals often exhibit low signal-to-noise ratios because of contamination from physiological and environmental artifacts. One of the major challenges hindering the real-world deployment of brain-computer interfaces (BCIs) involves the frequent occurrence of motion-related EEG artifacts. Most prior studies on EEG motion artifact removal rely on single-modality approaches, such as Artifact Subspace Reconstruction (ASR) and Independent Component Analysis (ICA), without incorporating simultaneously recorded modalities like inertial measurement units (IMUs), which directly capture the extent and dynamics of motion. This work proposes a fine-tuned large brain model (LaBraM)-based correlation attention mapping method that leverages spatial channel relationships in IMU data to identify motion-related artifacts in EEG signals. The fine-tuned model contains approximately 9.2 million parameters and uses 5.9 hours of EEG and IMU recordings for training, just 0.2346\% of the 2500 hours used to train the base model. We compare our results against the established ASR-ICA benchmark across varying time scales and motion activities, showing that incorporating IMU reference signals significantly improves robustness under diverse motion scenarios.

Yuhong Zhang, Jialu Li, Shilai Yang et al.

Reading comprehension is a fundamental skill in human cognitive development. With the advancement of Large Language Models (LLMs), there is a growing need to compare how humans and LLMs understand language across different contexts and apply this understanding to functional tasks such as inference, emotion interpretation, and information retrieval. Our previous work used LLMs and human biomarkers to study the reading comprehension process. The results showed that the biomarkers corresponding to words with high and low relevance to the inference target, as labeled by the LLMs, exhibited distinct patterns, particularly when validated using eye-tracking data. However, focusing solely on individual words limited the depth of understanding, which made the conclusions somewhat simplistic despite their potential significance. This study used an LLM-based AI agent to group words from a reading passage into nodes and edges, forming a graph-based text representation based on semantic meaning and question-oriented prompts. We then compare the distribution of eye fixations on important nodes and edges. Our findings indicate that LLMs exhibit high consistency in language understanding at the level of graph topological structure. These results build on our previous findings and offer insights into effective human-AI co-learning strategies.

Yuchen Xu, Olivia Tang, Yucheng Tang et al.

Segmentation of abdominal computed tomography(CT) provides spatial context, morphological properties, and a framework for tissue-specific radiomics to guide quantitative Radiological assessment. A 2015 MICCAI challenge spurred substantial innovation in multi-organ abdominal CT segmentation with both traditional and deep learning methods. Recent innovations in deep methods have driven performance toward levels for which clinical translation is appealing. However, continued cross-validation on open datasets presents the risk of indirect knowledge contamination and could result in circular reasoning. Moreover, 'real world' segmentations can be challenging due to the wide variability of abdomen physiology within patients. Herein, we perform two data retrievals to capture clinically acquired deidentified abdominal CT cohorts with respect to a recently published variation on 3D U-Net (baseline algorithm). First, we retrieved 2004 deidentified studies on 476 patients with diagnosis codes involving spleen abnormalities (cohort A). Second, we retrieved 4313 deidentified studies on 1754 patients without diagnosis codes involving spleen abnormalities (cohort B). We perform prospective evaluation of the existing algorithm on both cohorts, yielding 13% and 8% failure rate, respectively. Then, we identified 51 subjects in cohort A with segmentation failures and manually corrected the liver and gallbladder labels. We re-trained the model adding the manual labels, resulting in performance improvement of 9% and 6% failure rate for the A and B cohorts, respectively. In summary, the performance of the baseline on the prospective cohorts was similar to that on previously published datasets. Moreover, adding data from the first cohort substantively improved performance when evaluated on the second withheld validation cohort.

Yuchen Xu, Olivia Tang, Yucheng Tang et al.

Abdominal multi-organ segmentation of computed tomography (CT) images has been the subject of extensive research interest. It presents a substantial challenge in medical image processing, as the shape and distribution of abdominal organs can vary greatly among the population and within an individual over time. While continuous integration of novel datasets into the training set provides potential for better segmentation performance, collection of data at scale is not only costly, but also impractical in some contexts. Moreover, it remains unclear what marginal value additional data have to offer. Herein, we propose a single-pass active learning method through human quality assurance (QA). We built on a pre-trained 3D U-Net model for abdominal multi-organ segmentation and augmented the dataset either with outlier data (e.g., exemplars for which the baseline algorithm failed) or inliers (e.g., exemplars for which the baseline algorithm worked). The new models were trained using the augmented datasets with 5-fold cross-validation (for outlier data) and withheld outlier samples (for inlier data). Manual labeling of outliers increased Dice scores with outliers by 0.130, compared to an increase of 0.067 with inliers (p<0.001, two-tailed paired t-test). By adding 5 to 37 inliers or outliers to training, we find that the marginal value of adding outliers is higher than that of adding inliers. In summary, improvement on single-organ performance was obtained without diminishing multi-organ performance or significantly increasing training time. Hence, identification and correction of baseline failure cases present an effective and efficient method of selecting training data to improve algorithm performance.

Yucheng Tang, Ho Hin Lee, Yuchen Xu et al.

Dynamic contrast enhanced computed tomography (CT) is an imaging technique that provides critical information on the relationship of vascular structure and dynamics in the context of underlying anatomy. A key challenge for image processing with contrast enhanced CT is that phase discrepancies are latent in different tissues due to contrast protocols, vascular dynamics, and metabolism variance. Previous studies with deep learning frameworks have been proposed for classifying contrast enhancement with networks inspired by computer vision. Here, we revisit the challenge in the context of whole abdomen contrast enhanced CTs. To capture and compensate for the complex contrast changes, we propose a novel discriminator in the form of a multi-domain disentangled representation learning network. The goal of this network is to learn an intermediate representation that separates contrast enhancement from anatomy and enables classification of images with varying contrast time. Briefly, our unpaired contrast disentangling GAN(CD-GAN) Discriminator follows the ResNet architecture to classify a CT scan from different enhancement phases. To evaluate the approach, we trained the enhancement phase classifier on 21060 slices from two clinical cohorts of 230 subjects. Testing was performed on 9100 slices from 30 independent subjects who had been imaged with CT scans from all contrast phases. Performance was quantified in terms of the multi-class normalized confusion matrix. The proposed network significantly improved correspondence over baseline UNet, ResNet50 and StarGAN performance of accuracy scores 0.54. 0.55, 0.62 and 0.91, respectively. The proposed discriminator from the disentangled network presents a promising technique that may allow deeper modeling of dynamic imaging against patient specific anatomies.

Ho Hin Lee, Yucheng Tang, Olivia Tang et al.

Human in-the-loop quality assurance (QA) is typically performed after medical image segmentation to ensure that the systems are performing as intended, as well as identifying and excluding outliers. By performing QA on large-scale, previously unlabeled testing data, categorical QA scores can be generatedIn this paper, we propose a semi-supervised multi-organ segmentation deep neural network consisting of a traditional segmentation model generator and a QA involved discriminator. A large-scale dataset of 2027 volumes are used to train the generator, whose 2-D montage images and segmentation mask with QA scores are used to train the discriminator. To generate the QA scores, the 2-D montage images were reviewed manually and coded 0 (success), 1 (errors consistent with published performance), and 2 (gross failure). Then, the ResNet-18 network was trained with 1623 montage images in equal distribution of all three code labels and achieved an accuracy 94% for classification predictions with 404 montage images withheld for the test cohort. To assess the performance of using the QA supervision, the discriminator was used as a loss function in a multi-organ segmentation pipeline. The inclusion of QA-loss function boosted performance on the unlabeled test dataset from 714 patients to 951 patients over the baseline model. Additionally, the number of failures decreased from 606 (29.90%) to 402 (19.83%). The contributions of the proposed method are threefold: We show that (1) the QA scores can be used as a loss function to perform semi-supervised learning for unlabeled data, (2) the well trained discriminator is learnt by QA score rather than traditional true/false, and (3) the performance of multi-organ segmentation on unlabeled datasets can be fine-tuned with more robust and higher accuracy than the original baseline method.