Rumeng Li

Junda Wang, Zonghai Yao, Zhichao Yang et al.

We introduce NoteChat, a novel cooperative multi-agent framework leveraging Large Language Models (LLMs) to generate patient-physician dialogues. NoteChat embodies the principle that an ensemble of role-specific LLMs, through structured role-play and strategic prompting, can perform their assigned roles more effectively. The synergy among these role-playing LLMs results in a cohesive and efficient dialogue generation. Evaluation on MTS-dialogue, a benchmark dataset for patient-physician dialogues-note pairs, shows that models trained with the augmented synthetic patient-physician dialogues by NoteChat outperforms other state-of-the-art models for generating clinical notes. Our comprehensive automatic and human evaluation demonstrates that NoteChat substantially surpasses state-of-the-art models like ChatGPT and GPT-4 up to 22.78% by domain experts in generating superior synthetic patient-physician dialogues based on clinical notes. NoteChat has the potential to engage patients directly and help clinical documentation, a leading cause of physician burnout.

Rumeng Li, Xun Wang, Hong Yu

Large language models (LLMs) can generate natural language texts for various domains and tasks, but their potential for clinical text mining, a domain with scarce, sensitive, and imbalanced medical data, is underexplored. We investigate whether LLMs can augment clinical data for detecting Alzheimer's Disease (AD)-related signs and symptoms from electronic health records (EHRs), a challenging task that requires high expertise. We create a novel pragmatic taxonomy for AD sign and symptom progression based on expert knowledge, which guides LLMs to generate synthetic data following two different directions: "data-to-label", which labels sentences from a public EHR collection with AD-related signs and symptoms; and "label-to-data", which generates sentences with AD-related signs and symptoms based on the label definition. We train a system to detect AD-related signs and symptoms from EHRs, using three datasets: (1) a gold dataset annotated by human experts on longitudinal EHRs of AD patients; (2) a silver dataset created by the data-to-label method; and (3) a bronze dataset created by the label-to-data method. We find that using the silver and bronze datasets improves the system performance, outperforming the system using only the gold dataset. This shows that LLMs can generate synthetic clinical data for a complex task by incorporating expert knowledge, and our label-to-data method can produce datasets that are free of sensitive information, while maintaining acceptable quality.

Rumeng Li, Tao Wang, Xun Wang

Timeline Generation aims at summarizing news from different epochs and telling readers how an event evolves. It is a new challenge that combines salience ranking with novelty detection. For long-term public events, the main topic usually includes various aspects across different epochs and each aspect has its own evolving pattern. Existing approaches neglect such hierarchical topic structure involved in the news corpus in timeline generation. In this paper, we develop a novel time-dependent Hierarchical Dirichlet Model (HDM) for timeline generation. Our model can aptly detect different levels of topic information across corpus and such structure is further used for sentence selection. Based on the topic mined fro HDM, sentences are selected by considering different aspects such as relevance, coherence and coverage. We develop experimental systems to evaluate 8 long-term events that public concern. Performance comparison between different systems demonstrates the effectiveness of our model in terms of ROUGE metrics.