Alejandro Rodríguez‐González

Anastasia Krithara, Fotis Aisopos, Vassiliki Rentoumi et al.

The vision of IASIS project is to turn the wave of big biomedical data heading our way into actionable knowledge for decision makers. This is achieved by integrating data from disparate sources, including genomics, electronic health records and bibliography, and applying advanced analytics methods to discover useful patterns. The goal is to turn large amounts of available data into actionable information to authorities for planning public health activities and policies. The integration and analysis of these heterogeneous sources of information will enable the best decisions to be made, allowing for diagnosis and treatment to be personalised to each individual. The project offers a common representation schema for the heterogeneous data sources. The iASiS infrastructure is able to convert clinical notes into usable data, combine them with genomic data, related bibliography, image data and more, and create a global knowledge base. This facilitates the use of intelligent methods in order to discover useful patterns across different resources. Using semantic integration of data gives the opportunity to generate information that is rich, auditable and reliable. This information can be used to provide better care, reduce errors and create more confidence in sharing data, thus providing more insights and opportunities. Data resources for two different disease categories are explored within the iASiS use cases, dementia and lung cancer.

Daniel Gómez-Bravo, Aaron García, Guillermo Vigueras et al.

Pattern discovery is a machine learning technique that aims to find sets of items, subsequences, or substructures that are present in a dataset with a higher frequency value than a manually set threshold. This process helps to identify recurring patterns or relationships within the data, allowing for valuable insights and knowledge extraction. In this work, we propose Information Gained Subgroup Discovery (IGSD), a new SD algorithm for pattern discovery that combines Information Gain (IG) and Odds Ratio (OR) as a multi-criteria for pattern selection. The algorithm tries to tackle some limitations of state-of-the-art SD algorithms like the need for fine-tuning of key parameters for each dataset, usage of a single pattern search criteria set by hand, usage of non-overlapping data structures for subgroup space exploration, and the impossibility to search for patterns by fixing some relevant dataset variables. Thus, we compare the performance of IGSD with two state-of-the-art SD algorithms: FSSD and SSD++. Eleven datasets are assessed using these algorithms. For the performance evaluation, we also propose to complement standard SD measures with IG, OR, and p-value. Obtained results show that FSSD and SSD++ algorithms provide less reliable patterns and reduced sets of patterns than IGSD algorithm for all datasets considered. Additionally, IGSD provides better OR values than FSSD and SSD++, stating a higher dependence between patterns and targets. Moreover, patterns obtained for one of the datasets used, have been validated by a group of domain experts. Thus, patterns provided by IGSD show better agreement with experts than patterns obtained by FSSD and SSD++ algorithms. These results demonstrate the suitability of the IGSD as a method for pattern discovery and suggest that the inclusion of non-standard SD metrics allows to better evaluate discovered patterns.

Andrea Álvarez Pérez, Ana Iglesias-Molina, Lucía Prieto Santamaría et al.

There is a large number of online documents data sources available nowadays. The lack of structure and the differences between formats are the main difficulties to automatically extract information from them, which also has a negative impact on its use and reuse. In the biomedical domain, the DISNET platform emerged to provide researchers with a resource to obtain information in the scope of human disease networks by means of large-scale heterogeneous sources. Specifically in this domain, it is critical to offer not only the information extracted from different sources, but also the evidence that supports it. This paper proposes EBOCA, an ontology that describes (i) biomedical domain concepts and associations between them, and (ii) evidences supporting these associations; with the objective of providing an schema to improve the publication and description of evidences and biomedical associations in this domain. The ontology has been successfully evaluated to ensure there are no errors, modelling pitfalls and that it meets the previously defined functional requirements. Test data coming from a subset of DISNET and automatic association extractions from texts has been transformed according to the proposed ontology to create a Knowledge Graph that can be used in real scenarios, and which has also been used for the evaluation of the presented ontology.

José Alberto Benítez-Andrades, Isaías García-Rodríguez, Carmen Benavides et al.

Alcohol Use Disorder (AUD) is a major concern for public health organizations worldwide, especially as regards the adolescent population. The consumption of alcohol in adolescents is known to be influenced by seeing friends and even parents drinking alcohol. Building on this fact, a number of studies into alcohol consumption among adolescents have made use of Social Network Analysis (SNA) techniques to study the different social networks (peers, friends, family, etc.) with whom the adolescent is involved. These kinds of studies need an initial phase of data gathering by means of questionnaires and a subsequent analysis phase using the SNA techniques. The process involves a number of manual data handling stages that are time consuming and error-prone. The use of knowledge engineering techniques (including the construction of a domain ontology) to represent the information, allows the automation of all the activities, from the initial data collection to the results of the SNA study. This paper shows how a knowledge model is constructed, and compares the results obtained using the traditional method with this, fully automated model, detailing the main advantages of the latter. In the case of the SNA analysis, the validity of the results obtained with the knowledge engineering approach are compared to those obtained manually using the UCINET, Cytoscape, Pajek and Gephi to test the accuracy of the knowledge model.

José Alberto Benítez-Andrades, Alejandro Rodríguez-González, Carmen Benavides et al.

Social Network Analysis (SNA) is a set of techniques developed in the field of social and behavioral sciences research, in order to characterize and study the social relationships that are established among a set of individuals. When building a social network for performing an SNA analysis, an initial process of data gathering is achieved in order to extract the characteristics of the individuals and their relationships. This is usually done by completing a questionnaire containing different types of questions that will be later used to obtain the SNA measures needed to perform the study. There are, then, a great number of different possible network generating questions and also many possibilities for mapping the responses to the corresponding characteristics and relationships. Many variations may be introduced into these questions (the way they are posed, the weights given to each of the responses, etc.) that may have an effect on the resulting networks. All these different variations are difficult to achieve manually, because the process is time-consuming and error prone. The tool described in this paper uses semantic knowledge representation techniques in order to facilitate this kind of sensitivity studies. The base of the tool is a conceptual structure, called "ontology" that is able to represent the different concepts and their definitions. The tool is compared to other similar ones, and the advantages of the approach are highlighted, giving some particular examples from an ongoing SNA study about alcohol consumption habits in adolescents.

Ajinkya Khoche, Aron Asefaw, Alejandro Gonzalez et al.

Data annotation in autonomous vehicles is a critical step in the development of Deep Neural Network (DNN) based models or the performance evaluation of the perception system. This often takes the form of adding 3D bounding boxes on time-sequential and registered series of point-sets captured from active sensors like Light Detection and Ranging (LiDAR) and Radio Detection and Ranging (RADAR). When annotating multiple active sensors, there is a need to motion compensate and translate the points to a consistent coordinate frame and timestamp respectively. However, highly dynamic objects pose a unique challenge, as they can appear at different timestamps in each sensor's data. Without knowing the speed of the objects, their position appears to be different in different sensor outputs. Thus, even after motion compensation, highly dynamic objects are not matched from multiple sensors in the same frame, and human annotators struggle to add unique bounding boxes that capture all objects. This article focuses on addressing this challenge, primarily within the context of Scania collected datasets. The proposed solution takes a track of an annotated object as input and uses the Moving Horizon Estimation (MHE) to robustly estimate its speed. The estimated speed profile is utilized to correct the position of the annotated box and add boxes to object clusters missed by the original annotation.