Eduard Alarcon

Medina Bandic, Pablo le Henaff, Anabel Ovide et al.

Application-specific quantum computers offer the most efficient means to tackle problems intractable by classical computers. Realizing these architectures necessitates a deep understanding of quantum circuit properties and their relationship to execution outcomes on quantum devices. Our study aims to perform for the first time a rigorous examination of quantum circuits by introducing graph theory-based metrics extracted from their qubit interaction graph and gate dependency graph alongside conventional parameters describing the circuit itself. This methodology facilitates a comprehensive analysis and clustering of quantum circuits. Furthermore, it uncovers a connection between parameters rooted in both qubit interaction and gate dependency graphs, and the performance metrics for quantum circuit mapping, across a range of established quantum device and mapping configurations. Among the various device configurations, we particularly emphasize modular (i.e., multi-core) quantum computing architectures due to their high potential as a viable solution for quantum device scalability. This thorough analysis will help us to: i) identify key attributes of quantum circuits that affect the quantum circuit mapping performance metrics; ii) predict the performance on a specific chip for similar circuit structures; iii) determine preferable combinations of mapping techniques and hardware setups for specific circuits; and iv) define representative benchmark sets by clustering similarly structured circuits.

Ida Kleger-Rudomin, Filip Lemic, Sergi Abadal et al.

Liquid biopsy can detect tumor-derived biomarkers such as circulating tumor DNA (ctDNA), but ultra-low-fraction assays remain costly, slow, and difficult to scale. This motivates interest in intravascular in vivo sensing in the context of intrabody nanonetworks, where nanosensors could support local biomarker monitoring. BioFET-based nanosensors are relevant here because they are label-free, highly miniaturizable, and have shown strong ctDNA sensitivity in controlled media. We examine whether this sensitivity still yields reliable ctDNA detection in whole blood using a reduced-order stochastic simulation model that links operating-point selection, Debye-screened charge transduction, stochastic finite-capacity binding, nonspecific adsorption, background fluctuations, and intrinsic electronic noise to blank-threshold detection. Monte Carlo evaluation with physiologically grounded parameters shows that short Debye length and several-nanometer charge-to-channel separation attenuate the current shift, while low-frequency noise and background fluctuations reduce the margin between target-present and blank responses. Under the tested quasi-static charge-gating regime, the simulated current shifts do not reliably exceed the blank-derived threshold at low ctDNA concentrations. The model therefore provides a whole-blood boundary analysis that identifies which interface configurations and operating conditions most strongly limit reliable BioFET-based intravascular ctDNA detection.

Alfredo Ibias, Hector Antona, Guillem Ramirez-Miranda et al.

Unsupervised learning methods have a soft inspiration in cognition models. To this day, the most successful unsupervised learning methods revolve around clustering samples in a mathematical space. In this paper we propose a primitive-based, unsupervised learning approach for decision-making inspired by a novel cognition framework. This representation-centric approach models the input space constructively as a distributed hierarchical structure in an input-agnostic way. We compared our approach with both current state-of-the-art unsupervised learning classification, with current state-of-the-art small and incomplete datasets classification, and with current state-of-the-art cancer type classification. We show how our proposal outperforms previous state-of-the-art. We also evaluate some cognition-like properties of our proposal where it not only outperforms the compared algorithms (even supervised learning ones), but it also shows a different, more cognition-like, behaviour.

Abdollah Rezagholi, Sergi Abadal, Filip Lemic et al.

Early detection of cancer is essential for timely diagnosis and improved patient outcomes. Among emerging technologies, intra-body nanoscale communication offers an innovative solution to identify molecular cues within the human bloodstream. This study investigates a minimally invasive approach for early-stage cancer biomarker detection using nanomachines introduced into the bloodstream. To assess the feasibility of this approach, computational simulations are used to emulate the vascular environment and evaluate biomarker detection performance under different physiological conditions. Current modeling approaches often fail to capture essential vascular characteristics, including non-uniform flow structures, size-dependent particle mobility, and particle margination driven by red blood cell interactions. To address these limitations, our study incorporates these factors into the simulation framework and quantifies their individual and combined effects on biomarker detection efficiency. Baseline detection performance is first obtained under uniform flow assumptions, after which introducing realistic vascular transport mechanisms progressively reduces detection probability for all vessel types and nanomachine sizes. Among the considered vessels, capillary consistently achieves the highest detection probability across all nanomachine sizes.

Alfredo Ibias, Hector Antona, Guillem Ramirez-Miranda et al.

The Artificial Intelligence field seldom address the development of a fundamental building piece: a framework, methodology or algorithm to automatically build hierarchies of abstractions. This is a key requirement in order to build intelligent behaviour, as recent neuroscience studies clearly expose. In this paper we present a primitive-based framework to automatically generate hierarchies of constructive archetypes, as a theory of how to generate hierarchies of abstractions. We assume the existence of a primitive with very specific characteristics, and we develop our framework over it. We prove the effectiveness of our framework through mathematical definitions and proofs. Finally, we give a few insights about potential uses of our framework and the expected results.

Guillem Casadesus-Vila, Joan-Adria Ruiz-de-Azua, Eduard Alarcon

The upcoming landscape of Earth Observation missions will defined by networked heterogeneous nanosatellite constellations required to meet strict mission requirements, such as revisit times and spatial resolution. However, scheduling satellite communications in these satellite networks through efficiently creating a global satellite Contact Plan (CP) is a complex task, with current solutions requiring ground-based coordination or being limited by onboard computational resources. The paper proposes a novel approach to overcome these challenges by modeling the constellations and CP as dynamic networks and employing graph-based techniques. The proposed method utilizes a state-of-the-art dynamic graph neural network to evaluate the performance of a given CP and update it using a heuristic algorithm based on simulated annealing. The trained neural network can predict the network delay with a mean absolute error of 3.6 minutes. Simulation results show that the proposed method can successfully design a contact plan for large satellite networks, improving the delay by 29.1%, similar to a traditional approach, while performing the objective evaluations 20x faster.

Alfredo Ibias, Guillem Ramirez-Miranda, Enric Guinovart et al.

The Artificial Intelligence field is flooded with optimisation methods. In this paper, we change the focus to developing modelling methods with the aim of getting us closer to Artificial General Intelligence. To do so, we propose a novel way to interpret reality as an information source, that is later translated into a computational framework able to capture and represent such information. This framework is able to build elements of classical cognitive architectures, like Long Term Memory and Working Memory, starting from a simple primitive that only processes Spatial Distributed Representations. Moreover, it achieves such level of verticality in a seamless scalable hierarchical way.