Kim-Fung Tsang

Tong Zhou, Chen Ding, Changhong Jing et al.

The relationship between brain structure and function is critical for revealing the pathogenesis of brain disorders, including Alzheimer's disease (AD). However, mapping brain structure to function connections is a very challenging task. In this work, a bidirectional graph generative adversarial network (BG-GAN) is proposed to represent brain structure-function connections. Specifically, by designing a module incorporating inner graph convolution network (InnerGCN), the generators of BG-GAN can employ features of direct and indirect brain regions to learn the mapping function between the structural domain and the functional domain. Besides, a new module named Balancer is designed to counterpoise the optimization between generators and discriminators. By introducing the Balancer into BG-GAN, both the structural generator and functional generator can not only alleviate the issue of mode collapse but also learn complementarity of structural and functional features. Experimental results using the Alzheimer's Disease Neuroimaging Initiative (ADNI) dataset show that both generated structure and function connections can improve the identification accuracy of AD. The experimental findings suggest that the relationship between brain structure and function is not a complete one-to-one correspondence. They also suggest that brain structure is the basis of brain function, and the strong structural connections are majorly accompanied by strong functional connections.

Xuhang Chen, Michael Kwok-Po Ng, Kim-Fung Tsang et al.

Brain network analysis plays a crucial role in diagnosing and monitoring neurodegenerative disorders such as Alzheimer's disease (AD). Existing approaches for constructing structural brain networks from diffusion tensor imaging (DTI) often rely on specialized toolkits that suffer from inherent limitations: operator subjectivity, labor-intensive workflows, and restricted capacity to capture complex topological features and disease-specific biomarkers. To overcome these challenges and advance computational neuroimaging instrumentation, ConnectomeDiffuser is proposed as a novel diffusion-based framework for automated end-to-end brain network construction from DTI. The proposed model combines three key components: (1) a Template Network that extracts topological features from 3D DTI scans using Riemannian geometric principles, (2) a diffusion model that generates comprehensive brain networks with enhanced topological fidelity, and (3) a Graph Convolutional Network classifier that incorporates disease-specific markers to improve diagnostic accuracy. ConnectomeDiffuser demonstrates superior performance by capturing a broader range of structural connectivity and pathology-related information, enabling more sensitive analysis of individual variations in brain networks. Experimental validation on datasets representing two distinct neurodegenerative conditions demonstrates significant performance improvements over other brain network methods. This work contributes to the advancement of instrumentation in the context of neurological disorders, providing clinicians and researchers with a robust, generalizable measurement framework that facilitates more accurate diagnosis, deeper mechanistic understanding, and improved therapeutic monitoring of neurodegenerative diseases such as AD.

Wangyu Wu, Xuhang Chen, Zhenhong Chen et al.

Cross-Domain Sequential Recommendation (CDSR) plays a crucial role in modern consumer electronics and e-commerce platforms, where users interact with diverse services such as books, movies, and online retail products. These systems must accurately capture both domain-specific and cross-domain behavioral patterns to provide personalized and seamless consumer experiences. To address this challenge, we propose \textbf{TEMA-LLM} (\textit{Tag-Enriched Multi-Attention with Large Language Models}), a practical and effective framework that integrates \textit{Large Language Models (LLMs)} for semantic tag generation and enrichment. Specifically, TEMA-LLM employs LLMs to assign domain-aware prompts and generate descriptive tags from item titles and descriptions. The resulting tag embeddings are fused with item identifiers as well as textual and visual features to construct enhanced item representations. A \textit{Tag-Enriched Multi-Attention} mechanism is then introduced to jointly model user preferences within and across domains, enabling the system to capture complex and evolving consumer interests. Extensive experiments on four large-scale e-commerce datasets demonstrate that TEMA-LLM consistently outperforms state-of-the-art baselines, underscoring the benefits of LLM-based semantic tagging and multi-attention integration for consumer-facing recommendation systems. The proposed approach highlights the potential of LLMs to advance intelligent, user-centric services in the field of consumer electronics.