Sergio Benini

Michele Svanera, Mattia Savardi, Alberto Signoroni et al.

Many clinical and research studies of the human brain require an accurate structural MRI segmentation. While traditional atlas-based methods can be applied to volumes from any acquisition site, recent deep learning algorithms ensure very high accuracy only when tested on data from the same sites exploited in training (i.e., internal data). The performance degradation experienced on external data (i.e., unseen volumes from unseen sites) is due to the inter-site variabilities in intensity distributions induced by different MR scanner models, acquisition parameters, and unique artefacts. To mitigate this site-dependency, often referred to as the scanner effect, we propose LOD-Brain, a 3D convolutional neural network with progressive levels-of-detail (LOD) able to segment brain data from any site. Coarser network levels are responsible to learn a robust anatomical prior useful for identifying brain structures and their locations, while finer levels refine the model to handle site-specific intensity distributions and anatomical variations. We ensure robustness across sites by training the model on an unprecedented rich dataset aggregating data from open repositories: almost 27,000 T1w volumes from around 160 acquisition sites, at 1.5 - 3T, from a population spanning from 8 to 90 years old. Extensive tests demonstrate that LOD-Brain produces state-of-the-art results, with no significant difference in performance between internal and external sites, and robust to challenging anatomical variations. Its portability opens the way for large scale application across different healthcare institutions, patient populations, and imaging technology manufacturers. Code, model, and demo are available at the project website.

Alessandro Pagani, Marco Cominelli, Liying Han et al.

This paper presents a preliminary analysis of the ability of Chronos foundation model to process and internally represent frequency domain information. Foundation models that process time-series data offer practitioners a unified architecture capable of learning generic temporal representations across diverse tasks and domains, reducing the need for task-specific feature engineering and enabling transfer across signal modalities. Despite their growing adoption, the extent to which such models encode fundamental signal properties remains insufficiently characterised. We address this gap by analysing Chronos under controlled conditions, starting from the simplest class of signals: discrete sinusoids generated at fixed frequencies. Using lightweight online minimum description length probes applied to the decoder architecture, we test for the presence and separability of frequency information in the model's internal representations. The results provide insight into how frequential content is captured across the frequency spectrum and highlight regimes in which representation quality may degrade or require particular care. These findings offer practical guidance for users of Chronos in signal processing and information fusion contexts, and contribute to ongoing efforts to improve the interpretability and evaluation of foundation models for temporal data.

Alemu Sisay Nigru, Michele Svanera, Austin Dibble et al.

Accurate segmentation of infant brain MRI is critical for studying early neurodevelopment and diagnosing neurological disorders. Yet, it remains a fundamental challenge due to continuously evolving anatomy of the subjects, motion artifacts, and the scarcity of high-quality labeled data. In this work, we present LODi, a novel framework that utilizes prior knowledge from an adult brain MRI segmentation model to enhance the segmentation performance of infant scans. Given the abundance of publicly available adult brain MRI data, we pre-train a segmentation model on a large adult dataset as a starting point. Through transfer learning and domain adaptation strategies, we progressively adapt the model to the 0-2 year-old population, enabling it to account for the anatomical and imaging variability typical of infant scans. The adaptation of the adult model is carried out using weakly supervised learning on infant brain scans, leveraging silver-standard ground truth labels obtained with FreeSurfer. By introducing a novel training strategy that integrates hierarchical feature refinement and multi-level consistency constraints, our method enables fast, accurate, age-adaptive segmentation, while mitigating scanner and site-specific biases. Extensive experiments on both internal and external datasets demonstrate the superiority of our approach over traditional supervised learning and domain-specific models. Our findings highlight the advantage of leveraging adult brain priors as a foundation for age-flexible neuroimaging analysis, paving the way for more reliable and generalizable brain MRI segmentation across the lifespan.

Mahyar Gohari, Paolo Bestagini, Sergio Benini et al.

In the domain of music production and audio processing, the implementation of automatic pitch correction of the singing voice, also known as Auto-Tune, has significantly transformed the landscape of vocal performance. While auto-tuning technology has offered musicians the ability to tune their vocal pitches and achieve a desired level of precision, its use has also sparked debates regarding its impact on authenticity and artistic integrity. As a result, detecting and analyzing Auto-Tuned vocals in music recordings has become essential for music scholars, producers, and listeners. However, to the best of our knowledge, no prior effort has been made in this direction. This study introduces a data-driven approach leveraging triplet networks for the detection of Auto-Tuned songs, backed by the creation of a dataset composed of original and Auto-Tuned audio clips. The experimental results demonstrate the superiority of the proposed method in both accuracy and robustness compared to Rawnet2, an end-to-end model proposed for anti-spoofing and widely used for other audio forensic tasks.

Alberto Signoroni, Mattia Savardi, Sergio Benini et al.

In this work we design an end-to-end deep learning architecture for predicting, on Chest X-rays images (CXR), a multi-regional score conveying the degree of lung compromise in COVID-19 patients. Such semi-quantitative scoring system, namely Brixia~score, is applied in serial monitoring of such patients, showing significant prognostic value, in one of the hospitals that experienced one of the highest pandemic peaks in Italy. To solve such a challenging visual task, we adopt a weakly supervised learning strategy structured to handle different tasks (segmentation, spatial alignment, and score estimation) trained with a "from-the-part-to-the-whole" procedure involving different datasets. In particular, we exploit a clinical dataset of almost 5,000 CXR annotated images collected in the same hospital. Our BS-Net demonstrates self-attentive behavior and a high degree of accuracy in all processing stages. Through inter-rater agreement tests and a gold standard comparison, we show that our solution outperforms single human annotators in rating accuracy and consistency, thus supporting the possibility of using this tool in contexts of computer-assisted monitoring. Highly resolved (super-pixel level) explainability maps are also generated, with an original technique, to visually help the understanding of the network activity on the lung areas. We also consider other scores proposed in literature and provide a comparison with a recently proposed non-specific approach. We eventually test the performance robustness of our model on an assorted public COVID-19 dataset, for which we also provide Brixia~score annotations, observing good direct generalization and fine-tuning capabilities that highlight the portability of BS-Net in other clinical settings. The CXR dataset along with the source code and the trained model are publicly released for research purposes.

Dennis Bontempi, Sergio Benini, Alberto Signoroni et al.

Many functional and structural neuroimaging studies call for accurate morphometric segmentation of different brain structures starting from image intensity values of MRI scans. Current automatic (multi-) atlas-based segmentation strategies often lack accuracy on difficult-to-segment brain structures and, since these methods rely on atlas-to-scan alignment, they may take long processing times. Recently, methods deploying solutions based on Convolutional Neural Networks (CNNs) are making the direct analysis of out-of-the-scanner data feasible. However, current CNN-based solutions partition the test volume into 2D or 3D patches, which are processed independently. This entails a loss of global contextual information thereby negatively impacting the segmentation accuracy. In this work, we design and test an optimised end-to-end CNN architecture that makes the exploitation of global spatial information computationally tractable, allowing to process a whole MRI volume at once. We adopt a weakly supervised learning strategy by exploiting a large dataset composed by 947 out-of-the-scanner (3 Tesla T1-weighted 1mm isotropic MP-RAGE 3D sequences) MR Images. The resulting model is able to produce accurate multi-structure segmentation results in only few seconds. Different quantitative measures demonstrate an improved accuracy of our solution when compared to state-of-the-art techniques. Moreover, through a randomised survey involving expert neuroscientists, we show that subjective judgements clearly prefer our solution with respect to the widely adopted atlas-based FreeSurfer software.

Michele Svanera, Mattia Savardi, Alberto Signoroni et al.

We show how low-level formal features, such as shot duration, meant as length of camera takes, and shot scale, i.e. the distance between the camera and the subject, are distinctive of a director's style in art movies. So far such features were thought of not having enough varieties to become distinctive of an author. However our investigation on the full filmographies of six different authors (Scorsese, Godard, Tarr, Fellini, Antonioni, and Bergman) for a total number of 120 movies analysed second by second, confirms that these shot-related features do not appear as random patterns in movies from the same director. For feature extraction we adopt methods based on both conventional and deep learning techniques. Our findings suggest that feature sequential patterns, i.e. how features evolve in time, are at least as important as the related feature distributions. To the best of our knowledge this is the first study dealing with automatic attribution of movie authorship, which opens up interesting lines of cross-disciplinary research on the impact of style on the aesthetic and emotional effects on the viewers.

Michele Svanera, Sergio Benini, Gal Raz et al.

Deep neural networks have been developed drawing inspiration from the brain visual pathway, implementing an end-to-end approach: from image data to video object classes. However building an fMRI decoder with the typical structure of Convolutional Neural Network (CNN), i.e. learning multiple level of representations, seems impractical due to lack of brain data. As a possible solution, this work presents the first hybrid fMRI and deep features decoding approach: collected fMRI and deep learnt representations of video object classes are linked together by means of Kernel Canonical Correlation Analysis. In decoding, this allows exploiting the discriminatory power of CNN by relating the fMRI representation to the last layer of CNN (fc7). We show the effectiveness of embedding fMRI data onto a subspace related to deep features in distinguishing semantic visual categories based solely on brain imaging data.