Lu Zhang

Yanjun Lyu, Zihao Wu, Lu Zhang et al.

Pre-trained large language models(LLMs) have attracted increasing attention in biomedical domains due to their success in natural language processing. However, the complex traits and heterogeneity of multi-sources genomics data pose significant challenges when adapting these models to the bioinformatics and biomedical field. To address these challenges, we present GP-GPT, the first specialized large language model for genetic-phenotype knowledge representation and genomics relation analysis. Our model is fine-tuned in two stages on a comprehensive corpus composed of over 3,000,000 terms in genomics, proteomics, and medical genetics, derived from multiple large-scale validated datasets and scientific publications. GP-GPT demonstrates proficiency in accurately retrieving medical genetics information and performing common genomics analysis tasks, such as genomics information retrieval and relationship determination. Comparative experiments across domain-specific tasks reveal that GP-GPT outperforms state-of-the-art LLMs, including Llama2, Llama3 and GPT-4. These results highlight GP-GPT's potential to enhance genetic disease relation research and facilitate accurate and efficient analysis in the fields of genomics and medical genetics. Our investigation demonstrated the subtle changes of bio-factor entities' representations in the GP-GPT, which suggested the opportunities for the application of LLMs to advancing gene-phenotype research.

Anbin QI, Zhongliang Liu, Xinyong Zhou et al.

In this paper, we present our solution for the Second Multimodal Emotion Recognition Challenge Track 1(MER2024-SEMI). To enhance the accuracy and generalization performance of emotion recognition, we propose several methods for Multimodal Emotion Recognition. Firstly, we introduce EmoVCLIP, a model fine-tuned based on CLIP using vision-language prompt learning, designed for video-based emotion recognition tasks. By leveraging prompt learning on CLIP, EmoVCLIP improves the performance of pre-trained CLIP on emotional videos. Additionally, to address the issue of modality dependence in multimodal fusion, we employ modality dropout for robust information fusion. Furthermore, to aid Baichuan in better extracting emotional information, we suggest using GPT-4 as the prompt for Baichuan. Lastly, we utilize a self-training strategy to leverage unlabeled videos. In this process, we use unlabeled videos with high-confidence pseudo-labels generated by our model and incorporate them into the training set. Experimental results demonstrate that our model ranks 1st in the MER2024-SEMI track, achieving an accuracy of 90.15% on the test set.

Shaochen Xu, Yifan Zhou, Zhengliang Liu et al.

Artificial Intelligence (AI) has become essential in modern healthcare, with large language models (LLMs) offering promising advances in clinical decision-making. Traditional model-based approaches, including those leveraging in-context demonstrations and those with specialized medical fine-tuning, have demonstrated strong performance in medical language processing but struggle with real-time adaptability, multi-step reasoning, and handling complex medical tasks. Agent-based AI systems address these limitations by incorporating reasoning traces, tool selection based on context, knowledge retrieval, and both short- and long-term memory. These additional features enable the medical AI agent to handle complex medical scenarios where decision-making should be built on real-time interaction with the environment. Therefore, unlike conventional model-based approaches that treat medical queries as isolated questions, medical AI agents approach them as complex tasks and behave more like human doctors. In this paper, we study the choice of the backbone LLM for medical AI agents, which is the foundation for the agent's overall reasoning and action generation. In particular, we consider the emergent o1 model and examine its impact on agents' reasoning, tool-use adaptability, and real-time information retrieval across diverse clinical scenarios, including high-stakes settings such as intensive care units (ICUs). Our findings demonstrate o1's ability to enhance diagnostic accuracy and consistency, paving the way for smarter, more responsive AI tools that support better patient outcomes and decision-making efficacy in clinical practice.