Yang Wang

Muhammad Shaban, Yuzhou Chang, Huaying Qiu et al.

Foundation models have begun to transform image analysis by acting as pretrained generalist backbones that can be adapted to many tasks even when post-training data are limited, yet their impact on spatial proteomics, imaging that maps proteins at single-cell resolution, remains limited. Here, we introduce KRONOS, a foundation model built for spatial proteomics. KRONOS was trained in a self-supervised manner on over 47 million image patches covering 175 protein markers, 16 tissue types, and 8 fluorescence-based imaging platforms. We introduce key architectural adaptations to address the high-dimensional, multi-channel, and heterogeneous nature of multiplex imaging. We demonstrate that KRONOS learns biologically meaningful representations across multiple scales, ranging from cellular and microenvironment to tissue levels, enabling it to address diverse downstream tasks, including cell phenotyping, region classification, and patient stratification. Evaluated across 11 independent cohorts, KRONOS achieves state-of-the-art performance across cell phenotyping, treatment response prediction, and retrieval tasks, and is highly data-efficient. KRONOS also introduces the paradigm of segmentation-free patch-level processing for efficient and scalable spatial proteomics analysis, allowing cross-institutional comparisons, and as an image reverse search engine for spatial patterns. Together, these results position KRONOS as a flexible and scalable tool for spatial proteomics. The model is publicly accessible at https://github.com/mahmoodlab/KRONOS.

Tianhao Xie, Linlian Jiang, Xinxin Zuo et al.

Realistic scene appearance modeling has advanced rapidly with Gaussian Splatting, which enables real-time, high-quality rendering. Recent advances introduced per-primitive textures that incorporate spatial color variations within each Gaussian, improving their expressiveness. However, texture-based Gaussians parameterize appearance with a uniform per-Gaussian sampling grid, allocating equal sampling density regardless of local visual complexity. This leads to inefficient texture space utilization, where high-frequency regions are under-sampled and smooth regions waste capacity, causing blurred appearance and loss of fine structural detail. We introduce FACT-GS, a Frequency-Aligned Complexity-aware Texture Gaussian Splatting framework that allocates texture sampling density according to local visual frequency. Grounded in adaptive sampling theory, FACT-GS reformulates texture parameterization as a differentiable sampling-density allocation problem, replacing the uniform textures with a learnable frequency-aware allocation strategy implemented via a deformation field whose Jacobian modulates local sampling density. Built on 2D Gaussian Splatting, FACT-GS performs non-uniform sampling on fixed-resolution texture grids, preserving real-time performance while recovering sharper high-frequency details under the same parameter budget.

Yang Wang, Haiyang Mei, Qirui Bao et al.

We introduce a novel multimodality synergistic knowledge distillation scheme tailored for efficient single-eye motion recognition tasks. This method allows a lightweight, unimodal student spiking neural network (SNN) to extract rich knowledge from an event-frame multimodal teacher network. The core strength of this approach is its ability to utilize the ample, coarser temporal cues found in conventional frames for effective emotion recognition. Consequently, our method adeptly interprets both temporal and spatial information from the conventional frame domain, eliminating the need for specialized sensing devices, e.g., event-based camera. The effectiveness of our approach is thoroughly demonstrated using both existing and our compiled single-eye emotion recognition datasets, achieving unparalleled performance in accuracy and efficiency over existing state-of-the-art methods.