Ta Duc Huy

Xuyin Qi, Zeyu Zhang, Aaron Berliano Handoko et al.

Prostate cancer, a growing global health concern, necessitates precise diagnostic tools, with Magnetic Resonance Imaging (MRI) offering high-resolution soft tissue imaging that significantly enhances diagnostic accuracy. Recent advancements in explainable AI and representation learning have significantly improved prostate cancer diagnosis by enabling automated and precise lesion classification. However, existing explainable AI methods, particularly those based on frameworks like generative adversarial networks (GANs), are predominantly developed for natural image generation, and their application to medical imaging often leads to suboptimal performance due to the unique characteristics and complexity of medical image. To address these challenges, our paper introduces three key contributions. First, we propose ProjectedEx, a generative framework that provides interpretable, multi-attribute explanations, effectively linking medical image features to classifier decisions. Second, we enhance the encoder module by incorporating feature pyramids, which enables multiscale feedback to refine the latent space and improves the quality of generated explanations. Additionally, we conduct comprehensive experiments on both the generator and classifier, demonstrating the clinical relevance and effectiveness of ProjectedEx in enhancing interpretability and supporting the adoption of AI in medical settings. Code will be released at https://github.com/Richardqiyi/ProjectedEx

Ta Duc Huy, Sen Kim Tran, Phan Nguyen et al.

The ability to interpret and intervene model decisions is important for the adoption of computer-aided diagnosis methods in clinical workflows. Recent concept-based methods link the model predictions with interpretable concepts and modify their activation scores to interact with the model. However, these concepts are at the image level, which hinders the model from pinpointing the exact patches the concepts are activated. Alternatively, prototype-based methods learn representations from training image patches and compare these with test image patches, using the similarity scores for final class prediction. However, interpreting the underlying concepts of these patches can be challenging and often necessitates post-hoc guesswork. To address this issue, this paper introduces the novel Concept-based Similarity Reasoning network (CSR), which offers (i) patch-level prototype with intrinsic concept interpretation, and (ii) spatial interactivity. First, the proposed CSR provides localized explanation by grounding prototypes of each concept on image regions. Second, our model introduces novel spatial-level interaction, allowing doctors to engage directly with specific image areas, making it an intuitive and transparent tool for medical imaging. CSR improves upon prior state-of-the-art interpretable methods by up to 4.5\% across three biomedical datasets. Our code is released at https://github.com/tadeephuy/InteractCSR.

Ta Duc Huy, Duy Anh Huynh, Yutong Xie et al.

Visual grounding (VG) is the capability to identify the specific regions in an image associated with a particular text description. In medical imaging, VG enhances interpretability by highlighting relevant pathological features corresponding to textual descriptions, improving model transparency and trustworthiness for wider adoption of deep learning models in clinical practice. Current models struggle to associate textual descriptions with disease regions due to inefficient attention mechanisms and a lack of fine-grained token representations. In this paper, we empirically demonstrate two key observations. First, current VLMs assign high norms to background tokens, diverting the model's attention from regions of disease. Second, the global tokens used for cross-modal learning are not representative of local disease tokens. This hampers identifying correlations between the text and disease tokens. To address this, we introduce simple, yet effective Disease-Aware Prompting (DAP) process, which uses the explainability map of a VLM to identify the appropriate image features. This simple strategy amplifies disease-relevant regions while suppressing background interference. Without any additional pixel-level annotations, DAP improves visual grounding accuracy by 20.74% compared to state-of-the-art methods across three major chest X-ray datasets.

Abin Shoby, Ta Duc Huy, Tuan Dung Nguyen et al.

Vision Language models (VLMs) often hallucinate non-existent objects. Detecting hallucination is analogous to detecting deception: a single final statement is insufficient, one must examine the underlying reasoning process. Yet existing detectors rely mostly on final-layer signals. Attention-based methods assume hallucinated tokens exhibit low attention, while entropy-based ones use final-step uncertainty. Our analysis reveals the opposite: hallucinated objects can exhibit peaked attention due to contextual priors; and models often express high confidence because intermediate layers have already converged to an incorrect hypothesis. We show that the key to hallucination detection lies within the model's thought process, not its final output. By probing decoder layers, we uncover a previously overlooked behavior, overthinking: models repeatedly revise object hypotheses across layers before committing to an incorrect answer. Once the model latches onto a confounded hypothesis, it can propagate through subsequent layers, ultimately causing hallucination. To capture this behavior, we introduce the Overthinking Score, a metric to measure how many competing hypotheses the model entertains and how unstable these hypotheses are across layers. This score significantly improves hallucination detection: 78.9% F1 on MSCOCO and 71.58% on AMBER.