Kevin Nguyen

Alex Treacher, Kevin Nguyen, Dylan Owens et al.

This work demonstrates the ability to produce readily interpretable statistical metrics for model fit, fixed effects covariance coefficients, and prediction confidence. Importantly, this work compares 4 suitable and commonly applied epistemic UQ approaches, BNN, SWAG, MC dropout, and ensemble approaches in their ability to calculate these statistical metrics for the ARMED MEDL models. In our experiment for AD prognosis, not only do the UQ methods provide these benefits, but several UQ methods maintain the high performance of the original ARMED method, some even provide a modest (but not statistically significant) performance improvement. The ensemble models, especially the ensemble method with a 90% subsampling, performed well across all metrics we tested with (1) high performance that was comparable to the non-UQ ARMED model, (2) properly deweights the confounds probes and assigns them statistically insignificant p-values, (3) attains relatively high calibration of the output prediction confidence. Based on the results, the ensemble approaches, especially with a subsampling of 90%, provided the best all-round performance for prediction and uncertainty estimation, and achieved our goals to provide statistical significance for model fit, statistical significance covariate coefficients, and confidence in prediction, while maintaining the baseline performance of MEDL using ARMED

Sivajeet Chand, Kevin Nguyen, Peter Kuntz et al.

Large language models (LLMs) perform strongly on general-purpose code generation, yet their applicability to enterprise domain-specific languages (DSLs) remains underexplored, especially for repository-scale change generation spanning multiple files and folder structures from a single natural-language (NL) instruction. We report an industrial case study at BMW that adapts code-oriented LLMs to generate and modify project-root DSL artifacts for an Xtext-based DSL that drives downstream Java/TypeScript code generation. We develop an end-to-end pipeline for dataset construction, multi-file task representation, model adaptation, and evaluation. We encode DSL folder hierarchies as structured, path-preserving JSON, allowing single-response generation at repository scale and learning cross-file dependencies. We evaluate two instruction-tuned code LLMs (Qwen2.5-Coder and DeepSeek-Coder, 7B) under three configurations: baseline prompting, one-shot in-context learning, and parameter-efficient fine-tuning (QLoRA). Beyond standard similarity metrics, we introduce task-specific measures that assess edit correctness and repository structural fidelity. Fine-tuning yields the most significant gains across models and metrics, achieving high exact-match accuracy, substantial edit similarity, and structural fidelity of 1.00 on our held-out set for multi-file outputs. At the same time, one-shot in-context learning provides smaller but consistent improvements over baseline prompting. We further validate practical utility via an expert developer survey and an execution-based check using the existing code generator.

Elodie Germani, Nikhil Baghwat, Mathieu Dugré et al.

Parkinson's disease (PD) is a common neurodegenerative disorder with a poorly understood physiopathology and no established biomarkers for the diagnosis of early stages and for prediction of disease progression. Several neuroimaging biomarkers have been studied recently, but these are susceptible to several sources of variability related for instance to cohort selection or image analysis. In this context, an evaluation of the robustness of such biomarkers to variations in the data processing workflow is essential. This study is part of a larger project investigating the replicability of potential neuroimaging biomarkers of PD. Here, we attempt to reproduce (re-implementing the experiments with the same data, same method) and replicate (different data and/or method) the models described in [1] to predict individual's PD current state and progression using demographic, clinical and neuroimaging features (fALFF and ReHo extracted from resting-state fMRI). We use the Parkinson's Progression Markers Initiative dataset (PPMI, ppmi-info.org), as in [1] and aim to reproduce the original cohort, imaging features and machine learning models as closely as possible using the information available in the paper and the code. We also investigated methodological variations in cohort selection, feature extraction pipelines and sets of input features. Different criteria were used to evaluate the reproduction and compare the reproduced results with the original ones. Notably, we obtained significantly better than chance performance using the analysis pipeline closest to that in the original study (R2 \> 0), which is consistent with its findings. Moreover, using derived data provided by the authors of the original study, we were able to make an exact reproduction and managed to obtain results that were close to the original ones. The challenges encountered while reproducing and replicating the original work are likely explained by the complexity of neuroimaging studies, in particular in clinical settings. We provide recommendations to further facilitate the reproducibility of such studies in the future.