Santhosh Parampottupadam

Santhosh Parampottupadam, Andres Martinez, Dimitrios Bounias et al.

Federated learning (FL) enables multi-institutional training on clinical text without sharing raw data, but gradient inversion can reconstruct sensitive information from shared model updates. The extent of this leakage for radiology reports, and the role of tokenizer design, remains unclear. We quantify gradient-based text reconstruction in FL and compare privacy risk across three tokenizers with the model architecture held fixed. Six FL clients trained a GPT-2-style transformer (sequence length 32) on public radiology corpora (368,751 diagnostic reports, 98,206 discharge summaries, 1,500 MIMIC-CXR free-text reports) using the GPT-2, RadBERT, and LLaMA-2 tokenizers at batch sizes of 64, 128, and 256. Assuming an active malicious server that modifies the shared architecture before distribution, we applied analytic gradient inversion and measured reconstruction fidelity over five runs. Exact sentence reconstruction ranged from 31% to 44% across tokenizers (30.6-43.5% across the 27 tokenizer x dataset x batch-size cells). At batch size 64 on the Discharge dataset, accuracy was 42.1% (GPT-2), 42.3% (RadBERT), and 39.4% (LLaMA-2), decreasing to 37.3%, 37.2%, and 34.3% at batch size 256. S-BLEU declined as batch size grew (GPT-2: 0.44 to 0.33; RadBERT: 0.48 to 0.35). RadBERT yielded the highest reconstruction fidelity and recovered the most clinical terms (18.1% of a 1,440-term reference vocabulary, vs 12.5% for GPT-2 and 9.4% for LLaMA-2), yet no tokenizer prevented leakage. Substantial portions of report text are therefore recoverable from FL gradients even at larger batch sizes and with domain-specific tokenizers. Tokenizer design influences leakage severity and is a privacy-relevant decision, not only a utility one; safeguards such as secure aggregation and differential privacy are likely necessary to meet HIPAA and GDPR requirements for FL in radiology NLP.

Santhosh Parampottupadam, Melih Coşğun, Sarthak Pati et al.

Federated Learning (FL) offers a promising approach for training clinical AI models without centralizing sensitive patient data. However, its real-world adoption is hindered by challenges related to privacy, resource constraints, and compliance. Existing Differential Privacy (DP) approaches often apply uniform noise, which disproportionately degrades model performance, even among well-compliant institutions. In this work, we propose a novel compliance-aware FL framework that enhances DP by adaptively adjusting noise based on quantifiable client compliance scores. Additionally, we introduce a compliance scoring tool based on key healthcare and security standards to promote secure, inclusive, and equitable participation across diverse clinical settings. Extensive experiments on public datasets demonstrate that integrating under-resourced, less compliant clinics with highly regulated institutions yields accuracy improvements of up to 15% over traditional FL. This work advances FL by balancing privacy, compliance, and performance, making it a viable solution for real-world clinical workflows in global healthcare.