Remya Ampadi Ramachandran

Remya Ampadi Ramachandran, Lisa A. Tell, Sidharth Rai et al.

In the field of pharmacology, there is a notable absence of centralized, comprehensive, and up-to-date repositories of PK data. This poses a significant challenge for R&D as it can be a time-consuming and challenging task to collect all the required quantitative PK parameters from diverse scientific publications. This quantitative PK information is predominantly organized in tabular format, mostly available as XML, HTML, or PDF files within various online repositories and scientific publications, including supplementary materials. This makes tables one of the crucial components and information elements of scientific or regulatory documents as they are commonly utilized to present quantitative information. Extracting data from tables is typically a labor-intensive process, and alternative automated machine learning models may struggle to accurately detect and extract the relevant data due to the complex nature and diverse layouts of tabular data. The difficulty of information extraction and reading order detection is largely dependent on the structural complexity of the tables. Efforts to understand tables should prioritize capturing the content of table cells in a manner that aligns with how a human reader naturally comprehends the information. FARAD has been manually extracting tabular data and other information from literature and regulatory agencies for over 40 years. However, there is now an urgent need to automate this process due to the large volume of publications released daily. The accuracy of this task has become increasingly challenging, as manual extraction is tedious and prone to errors, especially given the staffing shortages we are currently facing. This necessitates the development of AI algorithms for table detection and extraction that are able to precisely handle cells organized according to the table structure, as indicated by column and/or row header information.

Majid Jaberi-Douraki, Hossein Sholehrasa, Xuan Xu et al.

The extraction and standardization of pharmacokinetic (PK) information from scientific literature remain significant challenges in computational pharmacology, which limits the reliability of data-driven models in drug development. Large language models (LLMs) have achieved remarkable progress in text understanding and reasoning, yet their adaptation to structured biomedical data, such as PK tables, remains constrained by heterogeneity, noise, and domain shift. To address these limitations, we propose HySim-LLM, a unified mathematical and computational framework that integrates embedding-weighted fine-tuning and manifold-aware denoising to enhance the robustness and interpretability of LLMs. We establish two theoretical results: (1) a similarity-weighted generalization bound that quantifies adaptation performance under embedding divergence, and (2) a manifold-based denoising guarantee that bounds loss contributions from noisy or off-manifold samples. These theorems provide a principled foundation for fine-tuning LLMs in structured biomedical settings. The framework offers a mathematically grounded pathway toward reliable and interpretable LLM adaptation for biomedical and data-intensive scientific domains.