Xiaochuan Pan

Emil Y. Sidky, Jakob H. Jørgensen, Xiaochuan Pan

The primal-dual optimization algorithm developed in Chambolle and Pock (CP), 2011 is applied to various convex optimization problems of interest in computed tomography (CT) image reconstruction. This algorithm allows for rapid prototyping of optimization problems for the purpose of designing iterative image reconstruction algorithms for CT. The primal-dual algorithm is briefly summarized in the article, and its potential for prototyping is demonstrated by explicitly deriving CP algorithm instances for many optimization problems relevant to CT. An example application modeling breast CT with low-intensity X-ray illumination is presented.

Jakob S. Jørgensen, Emil Y. Sidky, Per Christian Hansen et al.

In x-ray computed tomography (CT) it is generally acknowledged that reconstruction methods exploiting image sparsity allow reconstruction from a significantly reduced number of projections. The use of such reconstruction methods is motivated by recent progress in compressed sensing (CS). However, the CS framework provides neither guarantees of accurate CT reconstruction, nor any relation between sparsity and a sufficient number of measurements for recovery, i.e., perfect reconstruction from noise-free data. We consider reconstruction through 1-norm minimization, as proposed in CS, from data obtained using a standard CT fan-beam sampling pattern. In empirical simulation studies we establish quantitatively a relation between the image sparsity and the sufficient number of measurements for recovery within image classes motivated by tomographic applications. We show empirically that the specific relation depends on the image class and in many cases exhibits a sharp phase transition as seen in CS, i.e. same-sparsity image require the same number of projections for recovery. Finally we demonstrate that the relation holds independently of image size and is robust to small amounts of additive Gaussian noise.

Megan Lantz, Emil Y. Sidky, Ingrid S. Reiser et al.

Deep neural networks used for reconstructing sparse-view CT data are typically trained by minimizing a pixel-wise mean-squared error or similar loss function over a set of training images. However, networks trained with such pixel-wise losses are prone to wipe out small, low-contrast features that are critical for screening and diagnosis. To remedy this issue, we introduce a novel training loss inspired by the model observer framework to enhance the detectability of weak signals in the reconstructions. We evaluate our approach on the reconstruction of synthetic sparse-view breast CT data, and demonstrate an improvement in signal detectability with the proposed loss.

Yu Gao, Xiaochuan Pan, Chong Chen

This work investigates conditions for quantitative image reconstruction in multispectral computed tomography (MSCT), which remains a topic of active research. In MSCT, one seeks to obtain from data the spatial distribution of linear attenuation coefficient, referred to as a virtual monochromatic image (VMI), at a given X-ray energy, within the subject imaged. As a VMI is decomposed often into a linear combination of basis images with known decomposition coefficients, the reconstruction of a VMI is thus tantamount to that of the basis images. An empirical, but highly effective, two-step data-domain-decomposition (DDD) method has been developed and used widely for quantitative image reconstruction in MSCT. In the two-step DDD method, step (1) estimates the so-called basis sinogram from data through solving a nonlinear transform, whereas step (2) reconstructs basis images from their basis sinograms estimated. Subsequently, a VMI can readily be obtained from the linear combination of basis images reconstructed. As step (2) involves the inversion of a straightforward linear system, step (1) is the key component of the DDD method in which a nonlinear system needs to be inverted for estimating the basis sinograms from data. In this work, we consider a {\it discrete} form of the nonlinear system in step (1), and then carry out theoretical and numerical analyses of conditions on the existence, uniqueness, and stability of a solution to the discrete nonlinear system for accurately estimating the discrete basis sinograms, leading to quantitative reconstruction of VMIs in MSCT.