Yihan Liu

Zijie Fang, Yihan Liu, Yifeng Wang et al.

Biomarker detection is an indispensable part in the diagnosis and treatment of low-grade glioma (LGG). However, current LGG biomarker detection methods rely on expensive and complex molecular genetic testing, for which professionals are required to analyze the results, and intra-rater variability is often reported. To overcome these challenges, we propose an interpretable deep learning pipeline, a Multi-Biomarker Histomorphology Discoverer (Multi-Beholder) model based on the multiple instance learning (MIL) framework, to predict the status of five biomarkers in LGG using only hematoxylin and eosin-stained whole slide images and slide-level biomarker status labels. Specifically, by incorporating the one-class classification into the MIL framework, accurate instance pseudo-labeling is realized for instance-level supervision, which greatly complements the slide-level labels and improves the biomarker prediction performance. Multi-Beholder demonstrates superior prediction performance and generalizability for five LGG biomarkers (AUROC=0.6469-0.9735) in two cohorts (n=607) with diverse races and scanning protocols. Moreover, the excellent interpretability of Multi-Beholder allows for discovering the quantitative and qualitative correlations between biomarker status and histomorphology characteristics. Our pipeline not only provides a novel approach for biomarker prediction, enhancing the applicability of molecular treatments for LGG patients but also facilitates the discovery of new mechanisms in molecular functionality and LGG progression.

Ruiting Dai, Zheyu Wang, Haoyu Yang et al.

Data incompleteness severely impedes the reliability of multimodal systems. Existing reconstruction methods face distinct bottlenecks: conventional parametric/generative models are prone to hallucinations due to over-reliance on internal memory, while retrieval-augmented frameworks struggle with retrieval rigidity. Critically, these end-to-end architectures are fundamentally constrained by Semantic-Detail Entanglement -- a structural conflict between logical reasoning and signal synthesis that compromises fidelity. In this paper, we present \textbf{\underline{O}}mni-\textbf{\underline{M}}odality \textbf{\underline{G}}eneration Agent (\textbf{OMG-Agent}), a novel framework that shifts the paradigm from static mapping to a dynamic coarse-to-fine Agentic Workflow. By mimicking a \textit{deliberate-then-act} cognitive process, OMG-Agent explicitly decouples the task into three synergistic stages: (1) an MLLM-driven Semantic Planner that resolves input ambiguity via Progressive Contextual Reasoning, creating a deterministic structured semantic plan; (2) a non-parametric Evidence Retriever that grounds abstract semantics in external knowledge; and (3) a Retrieval-Injected Executor that utilizes retrieved evidence as flexible feature prompts to overcome rigidity and synthesize high-fidelity details. Extensive experiments on multiple benchmarks demonstrate that OMG-Agent consistently surpasses state-of-the-art methods, maintaining robustness under extreme missingness, e.g., a $2.6$-point gain on CMU-MOSI at $70$\% missing rates.

Teng Yan, Yihan Liu, Jiongxu Chen et al.

Long-term language-guided referring in fixed-view videos is challenging: the referent may be occluded or leave the scene for long intervals and later re-enter, while framewise referring pipelines drift as re-identification (ReID) becomes unreliable. AR2-4FV leverages background stability for long-term referring. An offline Anchor Bank is distilled from static background structures; at inference, the text query is aligned with this bank to produce an Anchor Map that serves as persistent semantic memory when the referent is absent. An anchor-based re-entry prior accelerates re-capture upon return, and a lightweight ReID-Gating mechanism maintains identity continuity using displacement cues in the anchor frame. The system predicts per-frame bounding boxes without assuming the target is visible in the first frame or explicitly modeling appearance variations. AR2-4FV achieves +10.3% Re-Capture Rate (RCR) improvement and -24.2% Re-Capture Latency (RCL) reduction over the best baseline, and ablation studies further confirm the benefits of the Anchor Map, re-entry prior, and ReID-Gating.