Sebastian Gruber

Tim J. Adler, Jan-Hinrich Nölke, Annika Reinke et al.

Current deep learning-based solutions for image analysis tasks are commonly incapable of handling problems to which multiple different plausible solutions exist. In response, posterior-based methods such as conditional Diffusion Models and Invertible Neural Networks have emerged; however, their translation is hampered by a lack of research on adequate validation. In other words, the way progress is measured often does not reflect the needs of the driving practical application. Closing this gap in the literature, we present the first systematic framework for the application-driven validation of posterior-based methods in inverse problems. As a methodological novelty, it adopts key principles from the field of object detection validation, which has a long history of addressing the question of how to locate and match multiple object instances in an image. Treating modes as instances enables us to perform mode-centric validation, using well-interpretable metrics from the application perspective. We demonstrate the value of our framework through instantiations for a synthetic toy example and two medical vision use cases: pose estimation in surgery and imaging-based quantification of functional tissue parameters for diagnostics. Our framework offers key advantages over common approaches to posterior validation in all three examples and could thus revolutionize performance assessment in inverse problems.

Sebastian Gruber, Tobias Harzfeld, Christoph G. Schuetz et al.

In distributed optimization, multiple parties collaborate to find an optimal solution to a problem. Privacy-preserving distributed optimization uses techniques, such as secure multi-party computation (MPC), to protect the private inputs of each party. In time-critical settings, the runtime overhead introduced by privacy-preserving computations may prevent the optimization from finishing within the deadline. This paper presents an approach for privacy-preserving distributed optimization in time-critical settings that combines evolutionary algorithms for solution search and MPC for the evaluation of solutions. The approach reduces the impact of privacy-preserving computations on runtime and allows to return solution within the deadline. Obfuscation of evaluation results provides additional protection for private inputs from an honest-but-curious platform provider, but introduces a potential trade-off between protection and solution quality. This trade-off is investigated in experiments using a genetic algorithm for both the single-objective assignment problem and the traveling salesperson problem, as well as NSGA-II for the multi-objective assignment problem.

David Haag, Devender Kumar, Sebastian Gruber et al.

We evaluated the viability of using Large Language Models (LLMs) to trigger and personalize content in Just-in-Time Adaptive Interventions (JITAIs) in digital health. As an interaction pattern representative of context-aware computing, JITAIs are being explored for their potential to support sustainable behavior change, adapting interventions to an individual's current context and needs. Challenging traditional JITAI implementation models, which face severe scalability and flexibility limitations, we tested GPT-4 for suggesting JITAIs in the use case of heart-healthy activity in cardiac rehabilitation. Using three personas representing patients affected by CVD with varying severeness and five context sets per persona, we generated 450 JITAI decisions and messages. These were systematically evaluated against those created by 10 laypersons (LayPs) and 10 healthcare professionals (HCPs). GPT-4-generated JITAIs surpassed human-generated intervention suggestions, outperforming both LayPs and HCPs across all metrics (i.e., appropriateness, engagement, effectiveness, and professionalism). These results highlight the potential of LLMs to enhance JITAI implementations in personalized health interventions, demonstrating how generative AI could revolutionize context-aware computing.

Christian Tomani, Sebastian Gruber, Muhammed Ebrar Erdem et al.

We address the problem of uncertainty calibration. While standard deep neural networks typically yield uncalibrated predictions, calibrated confidence scores that are representative of the true likelihood of a prediction can be achieved using post-hoc calibration methods. However, to date the focus of these approaches has been on in-domain calibration. Our contribution is two-fold. First, we show that existing post-hoc calibration methods yield highly over-confident predictions under domain shift. Second, we introduce a simple strategy where perturbations are applied to samples in the validation set before performing the post-hoc calibration step. In extensive experiments, we demonstrate that this perturbation step results in substantially better calibration under domain shift on a wide range of architectures and modelling tasks.