Isaac Yang

Holger R. Roth, Yan Cheng, Yuhong Wen et al.

Federated learning (FL) enables building robust and generalizable AI models by leveraging diverse datasets from multiple collaborators without centralizing the data. We created NVIDIA FLARE as an open-source software development kit (SDK) to make it easier for data scientists to use FL in their research and real-world applications. The SDK includes solutions for state-of-the-art FL algorithms and federated machine learning approaches, which facilitate building workflows for distributed learning across enterprises and enable platform developers to create a secure, privacy-preserving offering for multiparty collaboration utilizing homomorphic encryption or differential privacy. The SDK is a lightweight, flexible, and scalable Python package. It allows researchers to apply their data science workflows in any training libraries (PyTorch, TensorFlow, XGBoost, or even NumPy) in real-world FL settings. This paper introduces the key design principles of NVFlare and illustrates some use cases (e.g., COVID analysis) with customizable FL workflows that implement different privacy-preserving algorithms. Code is available at https://github.com/NVIDIA/NVFlare.

M. Jorge Cardoso, Wenqi Li, Richard Brown et al.

Artificial Intelligence (AI) is having a tremendous impact across most areas of science. Applications of AI in healthcare have the potential to improve our ability to detect, diagnose, prognose, and intervene on human disease. For AI models to be used clinically, they need to be made safe, reproducible and robust, and the underlying software framework must be aware of the particularities (e.g. geometry, physiology, physics) of medical data being processed. This work introduces MONAI, a freely available, community-supported, and consortium-led PyTorch-based framework for deep learning in healthcare. MONAI extends PyTorch to support medical data, with a particular focus on imaging, and provide purpose-specific AI model architectures, transformations and utilities that streamline the development and deployment of medical AI models. MONAI follows best practices for software-development, providing an easy-to-use, robust, well-documented, and well-tested software framework. MONAI preserves the simple, additive, and compositional approach of its underlying PyTorch libraries. MONAI is being used by and receiving contributions from research, clinical and industrial teams from around the world, who are pursuing applications spanning nearly every aspect of healthcare.

Holger R. Roth, Sarthak Tickoo, Mayank Kumar et al.

Fraud-related financial losses continue to rise, while regulatory, privacy, and data-sovereignty constraints increasingly limit the feasibility of centralized fraud detection systems. Federated Learning (FL) has emerged as a promising paradigm for enabling collaborative model training across institutions without sharing raw transaction data. Yet, its practical effectiveness under realistic, non-IID financial data distributions remains insufficiently validated. In this work, we present a multi-institution, industry-oriented proof-of-concept study evaluating federated anomaly detection for payment transactions using the NVIDIA FLARE framework. We simulate a realistic federation of heterogeneous financial institutions, each observing distinct fraud typologies and operating under strict data isolation. Using a deep neural network trained via federated averaging (FedAvg), we demonstrate that federated models achieve a mean F1-score of 0.903 - substantially outperforming locally trained models (0.643) and closely approaching centralized training performance (0.925), while preserving full data sovereignty. We further analyze convergence behavior, showing that strong performance is achieved within 10 federated communication rounds, highlighting the operational viability of FL in latency- and cost-sensitive financial environments. To support deployment in regulated settings, we evaluate model interpretability using Shapley-based feature attribution and confirm that federated models rely on semantically coherent, domain-relevant decision signals. Finally, we incorporate sample-level differential privacy via DP-SGD and demonstrate favorable privacy-utility trade-offs...

Lan Lu, Peiqi Yin, Isaac Yang et al.

Graph-based ANNS algorithms have gained increasing research interest and market adoption due to their efficiency and accuracy in retrieval. Existing approaches primarily rely on CPUs for graph index construction and retrieval, but this often requires significant time, especially for large-scale and high-dimensional datasets. Some studies have explored GPU-based solutions. However, GPUs are costly and their limited memory makes handling large datasets challenging. In this paper, we propose a novel end-to-end system ScaleGANN that enables users to efficiently construct graph indexes for large-scale, high-dimensional datasets by leveraging low-cost spot GPU resources in a distributed cloud system. ScaleGANN utilized the idea of divide-and-merge, with an optimized vector partitioning algorithm to further improve the indexing time and space efficiency while guaranteeing good index quality. Its novel resource allocation strategy realized multi-GPU indexing parallelism and overall cost-effectiveness for both build and query. Besides, we designed a task scheduler and cost model for better spot instance management and evaluation. We tested our system on large real-world datasets. Experiment results show that our approach can significantly accelerate the index build time to up to 9x times at even 6x lower price compared with the state-of-the-art extendable ANNS benchmark DiskANN.

Holger R. Roth, Ziyue Xu, Yuan-Ting Hsieh et al.

In the ever-evolving landscape of artificial intelligence (AI) and large language models (LLMs), handling and leveraging data effectively has become a critical challenge. Most state-of-the-art machine learning algorithms are data-centric. However, as the lifeblood of model performance, necessary data cannot always be centralized due to various factors such as privacy, regulation, geopolitics, copyright issues, and the sheer effort required to move vast datasets. In this paper, we explore how federated learning enabled by NVIDIA FLARE can address these challenges with easy and scalable integration capabilities, enabling parameter-efficient and full supervised fine-tuning of LLMs for natural language processing and biopharmaceutical applications to enhance their accuracy and robustness.