Iordanis Kerenidis

Natansh Mathur, Panagiotis Kl. Barkoutsos, Masako Yamada et al.

Training quantum neural networks (QNNs) on quantum hardware is currently bottlenecked by the cost of gradient estimation: standard parameter-shift methods require a number of circuit evaluations that grows quadratically with the number of trainable parameters, making hardware-based optimisation impractical beyond small system sizes. In this work, we introduce a training framework that reduces this cost to logarithmic in the number of qubits, making gradient-based QNN optimisation feasible on near-term hardware at increasing scales. Our framework combines three co-designed ingredients: (i) a structured, subspace-preserving Butterfly circuit architecture with $O(n \log n)$ parameters and logarithmic depth; (ii) a layer-wise training strategy that confines on-hardware optimisation to one small, well-structured layer at a time; and (iii) a parallelised parameter-shift rule that exploits the commuting structure within each Butterfly layer to extract all gradients in a constant number of circuit executions. Together these reduce the number of distinct circuit evaluations per optimisation step from $O(n^2)$ to $O(\log n)$. We validate the framework on clinical data imputation using the MIMIC-III electronic health record dataset, a demanding benchmark sensitive to optimisation instability and model variance. Hybrid classical-quantum models are trained directly on IonQ Forte Enterprise trapped-ion hardware at 16 qubits without performance degradation relative to ideal or noisy simulation and via tensor-network simulation at 32 qubits, with 32-qubit inference executed on hardware. The resulting models match or exceed strong classical neural baselines in downstream patient survival prediction while exhibiting reduced variance across runs, demonstrating that the proposed framework enables practical, scalable QNN training under realistic hardware constraints.

El Amine Cherrat, Iordanis Kerenidis, Natansh Mathur et al.

In this work, quantum transformers are designed and analysed in detail by extending the state-of-the-art classical transformer neural network architectures known to be very performant in natural language processing and image analysis. Building upon the previous work, which uses parametrised quantum circuits for data loading and orthogonal neural layers, we introduce three types of quantum transformers for training and inference, including a quantum transformer based on compound matrices, which guarantees a theoretical advantage of the quantum attention mechanism compared to their classical counterpart both in terms of asymptotic run time and the number of model parameters. These quantum architectures can be built using shallow quantum circuits and produce qualitatively different classification models. The three proposed quantum attention layers vary on the spectrum between closely following the classical transformers and exhibiting more quantum characteristics. As building blocks of the quantum transformer, we propose a novel method for loading a matrix as quantum states as well as two new trainable quantum orthogonal layers adaptable to different levels of connectivity and quality of quantum computers. We performed extensive simulations of the quantum transformers on standard medical image datasets that showed competitively, and at times better performance compared to the classical benchmarks, including the best-in-class classical vision transformers. The quantum transformers we trained on these small-scale datasets require fewer parameters compared to standard classical benchmarks. Finally, we implemented our quantum transformers on superconducting quantum computers and obtained encouraging results for up to six qubit experiments.

El Amine Cherrat, Snehal Raj, Iordanis Kerenidis et al.

Quantum machine learning has the potential for a transformative impact across industry sectors and in particular in finance. In our work we look at the problem of hedging where deep reinforcement learning offers a powerful framework for real markets. We develop quantum reinforcement learning methods based on policy-search and distributional actor-critic algorithms that use quantum neural network architectures with orthogonal and compound layers for the policy and value functions. We prove that the quantum neural networks we use are trainable, and we perform extensive simulations that show that quantum models can reduce the number of trainable parameters while achieving comparable performance and that the distributional approach obtains better performance than other standard approaches, both classical and quantum. We successfully implement the proposed models on a trapped-ion quantum processor, utilizing circuits with up to $16$ qubits, and observe performance that agrees well with noiseless simulation. Our quantum techniques are general and can be applied to other reinforcement learning problems beyond hedging.

El Amine Cherrat, Iordanis Kerenidis, Anupam Prakash

Quantum computing has shown the potential to substantially speed up machine learning applications, in particular for supervised and unsupervised learning. Reinforcement learning, on the other hand, has become essential for solving many decision making problems and policy iteration methods remain the foundation of such approaches. In this paper, we provide a general framework for performing quantum reinforcement learning via policy iteration. We validate our framework by designing and analyzing: \emph{quantum policy evaluation} methods for infinite horizon discounted problems by building quantum states that approximately encode the value function of a policy $π$; and \emph{quantum policy improvement} methods by post-processing measurement outcomes on these quantum states. Last, we study the theoretical and experimental performance of our quantum algorithms on two environments from OpenAI's Gym.

Giovanni Acampora, Andris Ambainis, Natalia Ares et al.

This white paper discusses and explores the various points of intersection between quantum computing and artificial intelligence (AI). It describes how quantum computing could support the development of innovative AI solutions. It also examines use cases of classical AI that can empower research and development in quantum technologies, with a focus on quantum computing and quantum sensing. The purpose of this white paper is to provide a long-term research agenda aimed at addressing foundational questions about how AI and quantum computing interact and benefit one another. It concludes with a set of recommendations and challenges, including how to orchestrate the proposed theoretical work, align quantum AI developments with quantum hardware roadmaps, estimate both classical and quantum resources - especially with the goal of mitigating and optimizing energy consumption - advance this emerging hybrid software engineering discipline, and enhance European industrial competitiveness while considering societal implications.

Iordanis Kerenidis, El-Amine Cherrat

We introduce quantum agents trained by episodic, reward-based reinforcement learning to autonomously rediscover several seminal quantum algorithms and protocols. In particular, our agents learn: efficient logarithmic-depth quantum circuits for the Quantum Fourier Transform; Grover's search algorithm; optimal cheating strategies for strong coin flipping; and optimal winning strategies for the CHSH and other nonlocal games. The agents achieve these results directly through interaction, without prior access to known optimal solutions. This demonstrates the potential of quantum intelligence as a tool for algorithmic discovery, opening the way for the automated design of novel quantum algorithms and protocols.

Sohum Thakkar, Skander Kazdaghli, Natansh Mathur et al.

Quantum algorithms have the potential to enhance machine learning across a variety of domains and applications. In this work, we show how quantum machine learning can be used to improve financial forecasting. First, we use classical and quantum Determinantal Point Processes to enhance Random Forest models for churn prediction, improving precision by almost 6%. Second, we design quantum neural network architectures with orthogonal and compound layers for credit risk assessment, which match classical performance with significantly fewer parameters. Our results demonstrate that leveraging quantum ideas can effectively enhance the performance of machine learning, both today as quantum-inspired classical ML solutions, and even more in the future, with the advent of better quantum hardware.

Iordanis Kerenidis, Anupam Prakash, Dániel Szilágyi

We present a quantum interior-point method (IPM) for second-order cone programming (SOCP) that runs in time $\widetilde{O} \left( n\sqrt{r} \frac{ζκ}{δ^2} \log \left(1/ε\right) \right)$ where $r$ is the rank and $n$ the dimension of the SOCP, $δ$ bounds the distance of intermediate solutions from the cone boundary, $ζ$ is a parameter upper bounded by $\sqrt{n}$, and $κ$ is an upper bound on the condition number of matrices arising in the classical IPM for SOCP. The algorithm takes as its input a suitable quantum description of an arbitrary SOCP and outputs a classical description of a $δ$-approximate $ε$-optimal solution of the given problem. Furthermore, we perform numerical simulations to determine the values of the aforementioned parameters when solving the SOCP up to a fixed precision $ε$. We present experimental evidence that in this case our quantum algorithm exhibits a polynomial speedup over the best classical algorithms for solving general SOCPs that run in time $O(n^{ω+0.5})$ (here, $ω$ is the matrix multiplication exponent, with a value of roughly $2.37$ in theory, and up to $3$ in practice). For the case of random SVM (support vector machine) instances of size $O(n)$, the quantum algorithm scales as $O(n^k)$, where the exponent $k$ is estimated to be $2.59$ using a least-squares power law. On the same family random instances, the estimated scaling exponent for an external SOCP solver is $3.31$ while that for a state-of-the-art SVM solver is $3.11$.

Iordanis Kerenidis, Alessandro Luongo, Anupam Prakash

The Expectation-Maximization (EM) algorithm is a fundamental tool in unsupervised machine learning. It is often used as an efficient way to solve Maximum Likelihood (ML) estimation problems, especially for models with latent variables. It is also the algorithm of choice to fit mixture models: generative models that represent unlabelled points originating from $k$ different processes, as samples from $k$ multivariate distributions. In this work we define and use a quantum version of EM to fit a Gaussian Mixture Model. Given quantum access to a dataset of $n$ vectors of dimension $d$, our algorithm has convergence and precision guarantees similar to the classical algorithm, but the runtime is only polylogarithmic in the number of elements in the training set, and is polynomial in other parameters - as the dimension of the feature space, and the number of components in the mixture. We generalize further the algorithm in two directions. First, we show how to fit any mixture model of probability distributions in the exponential family. Then, we show how to use this algorithm to compute the Maximum a Posteriori (MAP) estimate of a mixture model: the Bayesian approach to likelihood estimation problems. We discuss the performance of the algorithm on a dataset that is expected to be classified successfully by this algorithm, arguing that on those cases we can give strong guarantees on the runtime.

Iordanis Kerenidis, Jonas Landman, Alessandro Luongo et al.

Quantum machine learning is one of the most promising applications of a full-scale quantum computer. Over the past few years, many quantum machine learning algorithms have been proposed that can potentially offer considerable speedups over the corresponding classical algorithms. In this paper, we introduce q-means, a new quantum algorithm for clustering which is a canonical problem in unsupervised machine learning. The $q$-means algorithm has convergence and precision guarantees similar to $k$-means, and it outputs with high probability a good approximation of the $k$ cluster centroids like the classical algorithm. Given a dataset of $N$ $d$-dimensional vectors $v_i$ (seen as a matrix $V \in \mathbb{R}^{N \times d})$ stored in QRAM, the running time of q-means is $\widetilde{O}\left( k d \fracη{δ^2}κ(V)(μ(V) + k \fracηδ) + k^2 \frac{η^{1.5}}{δ^2} κ(V)μ(V) \right)$ per iteration, where $κ(V)$ is the condition number, $μ(V)$ is a parameter that appears in quantum linear algebra procedures and $η= \max_{i} ||v_{i}||^{2}$. For a natural notion of well-clusterable datasets, the running time becomes $\widetilde{O}\left( k^2 d \frac{η^{2.5}}{δ^3} + k^{2.5} \frac{η^2}{δ^3} \right)$ per iteration, which is linear in the number of features $d$, and polynomial in the rank $k$, the maximum square norm $η$ and the error parameter $δ$. Both running times are only polylogarithmic in the number of datapoints $N$. Our algorithm provides substantial savings compared to the classical $k$-means algorithm that runs in time $O(kdN)$ per iteration, particularly for the case of large datasets.

Jonathan Allcock, Chang-Yu Hsieh, Iordanis Kerenidis et al.

Quantum machine learning has the potential for broad industrial applications, and the development of quantum algorithms for improving the performance of neural networks is of particular interest given the central role they play in machine learning today. In this paper we present quantum algorithms for training and evaluating feedforward neural networks based on the canonical classical feedforward and backpropagation algorithms. Our algorithms rely on an efficient quantum subroutine for approximating the inner products between vectors in a robust way, and on implicitly storing large intermediate values in quantum random access memory for fast retrieval at later stages. The running times of our algorithms can be quadratically faster in the size of the network than their standard classical counterparts since they depend linearly on the number of neurons in the network, as opposed to the number of connections between neurons as in the classical case. This makes our algorithms suited for large-scale, highly-connected networks where the number of edges in the network dominates the classical algorithmic running time. Furthermore, networks trained by our quantum algorithm may have an intrinsic resilience to overfitting, as the algorithm naturally mimics the effects of classical techniques such as drop-out used to regularize networks. Our algorithms can also be used as the basis for new quantum-inspired classical algorithms which have the same dependence on the network dimensions as their quantum counterparts, but with quadratic overhead in other parameters that makes them relatively impractical.

Iordanis Kerenidis, Alessandro Luongo

Quantum machine learning carries the promise to revolutionize information and communication technologies. While a number of quantum algorithms with potential exponential speedups have been proposed already, it is quite difficult to provide convincing evidence that quantum computers with quantum memories will be in fact useful to solve real-world problems. Our work makes considerable progress towards this goal. We design quantum techniques for Dimensionality Reduction and for Classification, and combine them to provide an efficient and high accuracy quantum classifier that we test on the MNIST dataset. More precisely, we propose a quantum version of Slow Feature Analysis (QSFA), a dimensionality reduction technique that maps the dataset in a lower dimensional space where we can apply a novel quantum classification procedure, the Quantum Frobenius Distance (QFD). We simulate the quantum classifier (including errors) and show that it can provide classification of the MNIST handwritten digit dataset, a widely used dataset for benchmarking classification algorithms, with $98.5\%$ accuracy, similar to the classical case. The running time of the quantum classifier is polylogarithmic in the dimension and number of data points. We also provide evidence that the other parameters on which the running time depends (condition number, Frobenius norm, error threshold, etc.) scale favorably in practice, thus ascertaining the efficiency of our algorithm.

Iordanis Kerenidis, Adi Rosén, Florent Urrutia

We introduce a new information theoretic measure that we call Public Information Complexity (PIC), as a tool for the study of multi-party computation protocols, and of quantities such as their communication complexity, or the amount of randomness they require in the context of information-theoretic private computations. We are able to use this measure directly in the natural asynchronous message-passing peer-to-peer model and show a number of interesting properties and applications of our new notion: the Public Information Complexity is a lower bound on the Communication Complexity and an upper bound on the Information Complexity; the difference between the Public Information Complexity and the Information Complexity provides a lower bound on the amount of randomness used in a protocol; any communication protocol can be compressed to its Public Information Cost; an explicit calculation of the zero-error Public Information Complexity of the $k$-party, $n$-bit Parity function, where a player outputs the bit-wise parity of the inputs. The latter result also establishes that the amount of randomness needed by a private protocol that computes this function is $Ω(n)$.

Iordanis Kerenidis, Anupam Prakash

A recommendation system uses the past purchases or ratings of $n$ products by a group of $m$ users, in order to provide personalized recommendations to individual users. The information is modeled as an $m \times n$ preference matrix which is assumed to have a good rank-$k$ approximation, for a small constant $k$. In this work, we present a quantum algorithm for recommendation systems that has running time $O(\text{poly}(k)\text{polylog}(mn))$. All known classical algorithms for recommendation systems that work through reconstructing an approximation of the preference matrix run in time polynomial in the matrix dimension. Our algorithm provides good recommendations by sampling efficiently from an approximation of the preference matrix, without reconstructing the entire matrix. For this, we design an efficient quantum procedure to project a given vector onto the row space of a given matrix. This is the first algorithm for recommendation systems that runs in time polylogarithmic in the dimensions of the matrix and provides an example of a quantum machine learning algorithm for a real world application.