Tianxiang Hu

Xiangpeng Wei, Haoran Wei, Huan Lin et al.

Large language models (LLMs) demonstrate remarkable ability to comprehend, reason, and generate following nature language instructions. However, the development of LLMs has been primarily focused on high-resource languages, such as English, thereby limiting their applicability and research in other languages. Consequently, we present PolyLM, a multilingual LLM trained on 640 billion (B) tokens, avaliable in two model sizes: 1.7B and 13B. To enhance its multilingual capabilities, we 1) integrate bilingual data into training data; and 2) adopt a curriculum learning strategy that increases the proportion of non-English data from 30% in the first stage to 60% in the final stage during pre-training. Further, we propose a multilingual self-instruct method which automatically generates 132.7K diverse multilingual instructions for model fine-tuning. To assess the model's performance, we collect several existing multilingual tasks, including multilingual understanding, question answering, generation, and translation. Extensive experiments show that PolyLM surpasses other open-source models such as LLaMA and BLOOM on multilingual tasks while maintaining comparable performance in English. Our models, alone with the instruction data and multilingual benchmark, are available at: \url{https://modelscope.cn/models/damo/nlp_polylm_13b_text_generation}.

Renjie Zhou, Qiang Hu, Jian Wan et al.

Named Entity Recognition task is one of the core tasks of information extraction. Word ambiguity and word abbreviation are important reasons for the low recognition rate of named entities. In this paper, we propose a novel named entity recognition model WCL-BBCD (Word Contrastive Learning with BERT-BiLSTM-CRF-DBpedia), which incorporates the idea of contrastive learning. The model first trains the sentence pairs in the text, calculate similarity between sentence pairs, and fine-tunes BERT used for the named entity recognition task according to the similarity, so as to alleviate word ambiguity. Then, the fine-tuned BERT is combined with BiLSTM-CRF to perform the named entity recognition task. Finally, the recognition results are corrected in combination with prior knowledge such as knowledge graphs, so as to alleviate the low-recognition-rate problem caused by word abbreviations. The results of experimentals conducted on the CoNLL-2003 English dataset and OntoNotes V5 English dataset show that our model outperforms other similar models on.

Ruizhe Chen, Jianfei Yang, Huimin Xiong et al.

Recent discoveries have revealed that deep neural networks might behave in a biased manner in many real-world scenarios. For instance, deep networks trained on a large-scale face recognition dataset CelebA tend to predict blonde hair for females and black hair for males. Such biases not only jeopardize the robustness of models but also perpetuate and amplify social biases, which is especially concerning for automated decision-making processes in healthcare, recruitment, etc., as they could exacerbate unfair economic and social inequalities among different groups. Existing debiasing methods suffer from high costs in bias labeling or model re-training, while also exhibiting a deficiency in terms of elucidating the origins of biases within the model. To this respect, we propose a fast model debiasing framework (FMD) which offers an efficient approach to identify, evaluate and remove biases inherent in trained models. The FMD identifies biased attributes through an explicit counterfactual concept and quantifies the influence of data samples with influence functions. Moreover, we design a machine unlearning-based strategy to efficiently and effectively remove the bias in a trained model with a small counterfactual dataset. Experiments on the Colored MNIST, CelebA, and Adult Income datasets along with experiments with large language models demonstrate that our method achieves superior or competing accuracies compared with state-of-the-art methods while attaining significantly fewer biases and requiring much less debiasing cost. Notably, our method requires only a small external dataset and updating a minimal amount of model parameters, without the requirement of access to training data that may be too large or unavailable in practice.

Jiaxiang Liu, Tianxiang Hu, Yan Zhang et al.

Zero-shot medical image classification is a critical process in real-world scenarios where we have limited access to all possible diseases or large-scale annotated data. It involves computing similarity scores between a query medical image and possible disease categories to determine the diagnostic result. Recent advances in pretrained vision-language models (VLMs) such as CLIP have shown great performance for zero-shot natural image recognition and exhibit benefits in medical applications. However, an explainable zero-shot medical image recognition framework with promising performance is yet under development. In this paper, we propose a novel CLIP-based zero-shot medical image classification framework supplemented with ChatGPT for explainable diagnosis, mimicking the diagnostic process performed by human experts. The key idea is to query large language models (LLMs) with category names to automatically generate additional cues and knowledge, such as disease symptoms or descriptions other than a single category name, to help provide more accurate and explainable diagnosis in CLIP. We further design specific prompts to enhance the quality of generated texts by ChatGPT that describe visual medical features. Extensive results on one private dataset and four public datasets along with detailed analysis demonstrate the effectiveness and explainability of our training-free zero-shot diagnosis pipeline, corroborating the great potential of VLMs and LLMs for medical applications.

Man Yao, Jiakui Hu, Tianxiang Hu et al.

Neuromorphic computing, which exploits Spiking Neural Networks (SNNs) on neuromorphic chips, is a promising energy-efficient alternative to traditional AI. CNN-based SNNs are the current mainstream of neuromorphic computing. By contrast, no neuromorphic chips are designed especially for Transformer-based SNNs, which have just emerged, and their performance is only on par with CNN-based SNNs, offering no distinct advantage. In this work, we propose a general Transformer-based SNN architecture, termed as ``Meta-SpikeFormer", whose goals are: 1) Lower-power, supports the spike-driven paradigm that there is only sparse addition in the network; 2) Versatility, handles various vision tasks; 3) High-performance, shows overwhelming performance advantages over CNN-based SNNs; 4) Meta-architecture, provides inspiration for future next-generation Transformer-based neuromorphic chip designs. Specifically, we extend the Spike-driven Transformer in \citet{yao2023spike} into a meta architecture, and explore the impact of structure, spike-driven self-attention, and skip connection on its performance. On ImageNet-1K, Meta-SpikeFormer achieves 80.0\% top-1 accuracy (55M), surpassing the current state-of-the-art (SOTA) SNN baselines (66M) by 3.7\%. This is the first direct training SNN backbone that can simultaneously supports classification, detection, and segmentation, obtaining SOTA results in SNNs. Finally, we discuss the inspiration of the meta SNN architecture for neuromorphic chip design. Source code and models are available at \url{https://github.com/BICLab/Spike-Driven-Transformer-V2}.

Jiaxiang Liu, Tianxiang Hu, Yang Feng et al.

In computer-assisted orthodontics, three-dimensional tooth models are required for many medical treatments. Tooth segmentation from cone-beam computed tomography (CBCT) images is a crucial step in constructing the models. However, CBCT image quality problems such as metal artifacts and blurring caused by shooting equipment and patients' dental conditions make the segmentation difficult. In this paper, we propose ToothSegNet, a new framework which acquaints the segmentation model with generated degraded images during training. ToothSegNet merges the information of high and low quality images from the designed degradation simulation module using channel-wise cross fusion to reduce the semantic gap between encoder and decoder, and also refines the shape of tooth prediction through a structural constraint loss. Experimental results suggest that ToothSegNet produces more precise segmentation and outperforms the state-of-the-art medical image segmentation methods.

Man Yao, Xuerui Qiu, Tianxiang Hu et al.

The ambition of brain-inspired Spiking Neural Networks (SNNs) is to become a low-power alternative to traditional Artificial Neural Networks (ANNs). This work addresses two major challenges in realizing this vision: the performance gap between SNNs and ANNs, and the high training costs of SNNs. We identify intrinsic flaws in spiking neurons caused by binary firing mechanisms and propose a Spike Firing Approximation (SFA) method using integer training and spike-driven inference. This optimizes the spike firing pattern of spiking neurons, enhancing efficient training, reducing power consumption, improving performance, enabling easier scaling, and better utilizing neuromorphic chips. We also develop an efficient spike-driven Transformer architecture and a spike-masked autoencoder to prevent performance degradation during SNN scaling. On ImageNet-1k, we achieve state-of-the-art top-1 accuracy of 78.5\%, 79.8\%, 84.0\%, and 86.2\% with models containing 10M, 19M, 83M, and 173M parameters, respectively. For instance, the 10M model outperforms the best existing SNN by 7.2\% on ImageNet, with training time acceleration and inference energy efficiency improved by 4.5$\times$ and 3.9$\times$, respectively. We validate the effectiveness and efficiency of the proposed method across various tasks, including object detection, semantic segmentation, and neuromorphic vision tasks. This work enables SNNs to match ANN performance while maintaining the low-power advantage, marking a significant step towards SNNs as a general visual backbone. Code is available at https://github.com/BICLab/Spike-Driven-Transformer-V3.

Huimin Xiong, Zijie Meng, Tianxiang Hu et al.

3D intraoral scans (IOS) are increasingly adopted in routine dentistry due to abundant geometric evidence, and unified multi-disease diagnosis is desirable for clinical documentation and communication. While recent works introduce dental vision-language models (VLMs) to enable unified diagnosis and report generation on 2D images or multi-view images rendered from IOS, they do not fully leverage native 3D geometry. Such work is necessary and also challenging, due to: (i) heterogeneous scan forms and the complex IOS topology, (ii) multi-disease co-occurrence with class imbalance and fine-grained morphological ambiguity, (iii) limited paired 3D IOS-text data. Thus, we present IOSVLM, an end-to-end 3D VLM that represents scans as point clouds and follows a 3D encoder-projector-LLM design for unified diagnosis and generative visual question-answering (VQA), together with IOSVQA, a large-scale multi-source IOS diagnosis VQA dataset comprising 19,002 cases and 249,055 VQA pairs over 23 oral diseases and heterogeneous scan types. To address the distribution gap between color-free IOS data and color-dependent 3D pre-training, we propose a geometry-to-chromatic proxy that stabilizes fine-grained geometric perception and cross-modal alignment. A two-stage curriculum training strategy further enhances robustness. IOSVLM consistently outperforms strong baselines, achieving gains of at least +9.58% macro accuracy and +1.46% macro F1, indicating the effectiveness of direct 3D geometry modeling for IOS-based diagnosis.

Songtao Jiang, Yuan Wang, Sibo Song et al.

Real-world clinical decision-making requires integrating heterogeneous data, including medical text, 2D images, 3D volumes, and videos, while existing AI systems fail to unify all these signals, limiting their utility. In this paper, we introduce Hulu-Med, a transparent, generalist medical Vision-Language Model (VLM) designed to unify language-only, 2D/3D vision-language, and video understanding within a single architecture. Hulu-Med is trained on a curated corpus of 16.7 million samples, comprising exclusively public or synthetic data, spanning 12 major anatomical systems and 14 medical imaging modalities. Hulu-Med employs a medical-aware token-reduction strategy that prunes redundant visual tokens, achieving up to a 55% reduction for 3D and video inputs, improving cross-modal efficiency, and enabling training at 7B-32B parameter scales in approximately 4,000-40,000 GPU hours. Across 30 public in-domain and out-of-domain medical benchmarks-covering text reasoning, visual question answering, report generation, multilingual dialogue, video understanding, and rare disease diagnosis-Hulu-Med surpasses existing open-source models on 27 of 30 benchmarks and outperforms proprietary systems such as GPT-4o on 16 benchmarks. Despite being a VLM, Hulu-Med outperforms GPT-4o and matches GPT-o1 on the text-only HealthBench. For the first time in the community, we provide a fully transparent, reproducible and cost-effective pipeline for holistic medical vision-language understanding by releasing our end-to-end data curation, training procedures, and model parameters. Code and models are available at https://github.com/ZJUI-AI4H/Hulu-Med.

Zijie Meng, Jin Hao, Xiwei Dai et al.

Diagnosing and managing oral diseases necessitate advanced visual interpretation across diverse imaging modalities and integrated information synthesis. While current AI models excel at isolated tasks, they often fall short in addressing the complex, multimodal requirements of comprehensive clinical dental practice. Here we introduce DentVLM, a multimodal vision-language model engineered for expert-level oral disease diagnosis. DentVLM was developed using a comprehensive, large-scale, bilingual dataset of 110,447 images and 2.46 million visual question-answering (VQA) pairs. The model is capable of interpreting seven 2D oral imaging modalities across 36 diagnostic tasks, significantly outperforming leading proprietary and open-source models by 19.6% higher accuracy for oral diseases and 27.9% for malocclusions. In a clinical study involving 25 dentists, evaluating 1,946 patients and encompassing 3,105 QA pairs, DentVLM surpassed the diagnostic performance of 13 junior dentists on 21 of 36 tasks and exceeded that of 12 senior dentists on 12 of 36 tasks. When integrated into a collaborative workflow, DentVLM elevated junior dentists' performance to senior levels and reduced diagnostic time for all practitioners by 15-22%. Furthermore, DentVLM exhibited promising performance across three practical utility scenarios, including home-based dental health management, hospital-based intelligent diagnosis and multi-agent collaborative interaction. These findings establish DentVLM as a robust clinical decision support tool, poised to enhance primary dental care, mitigate provider-patient imbalances, and democratize access to specialized medical expertise within the field of dentistry.

Jianhui Wei, Zijie Meng, Zikai Xiao et al.

While Medical Large Language Models (MedLLMs) have demonstrated remarkable potential in clinical tasks, their ethical safety remains insufficiently explored. This paper introduces $\textbf{MedEthicsQA}$, a comprehensive benchmark comprising $\textbf{5,623}$ multiple-choice questions and $\textbf{5,351}$ open-ended questions for evaluation of medical ethics in LLMs. We systematically establish a hierarchical taxonomy integrating global medical ethical standards. The benchmark encompasses widely used medical datasets, authoritative question banks, and scenarios derived from PubMed literature. Rigorous quality control involving multi-stage filtering and multi-faceted expert validation ensures the reliability of the dataset with a low error rate ($2.72\%$). Evaluation of state-of-the-art MedLLMs exhibit declined performance in answering medical ethics questions compared to their foundation counterparts, elucidating the deficiencies of medical ethics alignment. The dataset, registered under CC BY-NC 4.0 license, is available at https://github.com/JianhuiWei7/MedEthicsQA.

Zhiting Fan, Ruizhe Chen, Tianxiang Hu et al.

Large language models (LLMs) achieve strong downstream performance largely due to abundant supervised fine-tuning (SFT) data. However, high-quality SFT data in knowledge-intensive domains such as humanities, social sciences, medicine, law, and finance is scarce because expert curation is expensive, privacy constraints are strict, and label consistency is hard to ensure. Recent work uses synthetic data, typically by prompting a generator over domain documents and filtering outputs with handcrafted rubrics. Yet rubric design is expert-dependent, transfers poorly across domains, and is often optimized through a brittle heuristic loop of writing rubrics, synthesizing data, training, inspecting results, and manually guessing revisions. This process lacks reliable quantitative feedback about how a rubric affects downstream performance. We propose evaluating synthetic data by its training utility on the target model and using this signal to guide data generation. Inspired by influence estimation, we adopt an optimizer-aware estimator that uses gradient information to quantify each synthetic sample's contribution to a target model's objective on specific tasks. Our analysis shows that even when synthetic and real samples are close in embedding space, their influence on learning can differ substantially. Based on this insight, we propose an optimization-based framework that adapts rubrics using target-model feedback. We provide lightweight guiding text and use a rubric-specialized model to generate task-conditioned rubrics. Influence score is used as the reward to optimize the rubric generator with reinforcement learning. Experiments across domains, target models, and data generators show consistent improvements and strong generalization without task-specific tuning.

Zhiting Fan, Ruizhe Chen, Tianxiang Hu et al.

The growing use of large language model (LLM)-based chatbots has raised concerns about fairness. Fairness issues in LLMs can lead to severe consequences, such as bias amplification, discrimination, and harm to marginalized communities. While existing fairness benchmarks mainly focus on single-turn dialogues, multi-turn scenarios, which in fact better reflect real-world conversations, present greater challenges due to conversational complexity and potential bias accumulation. In this paper, we propose a comprehensive fairness benchmark for LLMs in multi-turn dialogue scenarios, \textbf{FairMT-Bench}. Specifically, we formulate a task taxonomy targeting LLM fairness capabilities across three stages: context understanding, user interaction, and instruction trade-offs, with each stage comprising two tasks. To ensure coverage of diverse bias types and attributes, we draw from existing fairness datasets and employ our template to construct a multi-turn dialogue dataset, \texttt{FairMT-10K}. For evaluation, GPT-4 is applied, alongside bias classifiers including Llama-Guard-3 and human validation to ensure robustness. Experiments and analyses on \texttt{FairMT-10K} reveal that in multi-turn dialogue scenarios, current LLMs are more likely to generate biased responses, and there is significant variation in performance across different tasks and models. Based on this, we curate a challenging dataset, \texttt{FairMT-1K}, and test 15 current state-of-the-art (SOTA) LLMs on this dataset. The results show the current state of fairness in LLMs and showcase the utility of this novel approach for assessing fairness in more realistic multi-turn dialogue contexts, calling for future work to focus on LLM fairness improvement and the adoption of \texttt{FairMT-1K} in such efforts.

Ruizhe Chen, Tianxiang Hu, Yang Feng et al.

Concerns regarding Large Language Models (LLMs) to memorize and disclose private information, particularly Personally Identifiable Information (PII), become prominent within the community. Many efforts have been made to mitigate the privacy risks. However, the mechanism through which LLMs memorize PII remains poorly understood. To bridge this gap, we introduce a pioneering method for pinpointing PII-sensitive neurons (privacy neurons) within LLMs. Our method employs learnable binary weight masks to localize specific neurons that account for the memorization of PII in LLMs through adversarial training. Our investigations discover that PII is memorized by a small subset of neurons across all layers, which shows the property of PII specificity. Furthermore, we propose to validate the potential in PII risk mitigation by deactivating the localized privacy neurons. Both quantitative and qualitative experiments demonstrate the effectiveness of our neuron localization algorithm.

Songtao Jiang, Yan Zhang, Ruizhe Chen et al.

Multimodal large language models (MLLMs) have achieved remarkable success across various tasks. However, separate training of visual and textual encoders often results in a misalignment of the modality. Such misalignment may lead models to generate content that is absent from the input image, a phenomenon referred to as hallucination. These inaccuracies severely undermine the trustworthiness of MLLMs in real-world applications. Despite attempts to optimize text preferences to mitigate this issue, our initial investigation indicates that the trustworthiness of MLLMs remains inadequate. Specifically, these models tend to provide preferred answers even when the input image is heavily distorted. Analysis of visual token attention also indicates that the model focuses primarily on the surrounding context rather than the key object referenced in the question. These findings highlight a misalignment between the modalities, where answers inadequately leverage input images. Motivated by our findings, we propose Modality-Fair Preference Optimization (MFPO), which comprises three components: the construction of a multimodal preference dataset in which dispreferred images differ from originals solely in key regions; an image reward loss function encouraging the model to generate answers better aligned with the input images; and an easy-to-hard iterative alignment strategy to stabilize joint modality training. Extensive experiments on three trustworthiness benchmarks demonstrate that MFPO significantly enhances the trustworthiness of MLLMs. In particular, it enables the 7B models to attain trustworthiness levels on par with, or even surpass, those of the 13B, 34B, and larger models.

Jiaxiang Liu, Tianxiang Hu, Jiawei Du et al.

Visual Language Models such as CLIP excel in image recognition due to extensive image-text pre-training. However, applying the CLIP inference in zero-shot classification, particularly for medical image diagnosis, faces challenges due to: 1) the inadequacy of representing image classes solely with single category names; 2) the modal gap between the visual and text spaces generated by CLIP encoders. Despite attempts to enrich disease descriptions with large language models, the lack of class-specific knowledge often leads to poor performance. In addition, empirical evidence suggests that existing proxy learning methods for zero-shot image classification on natural image datasets exhibit instability when applied to medical datasets. To tackle these challenges, we introduce the Knowledge Proxy Learning (KPL) to mine knowledge from CLIP. KPL is designed to leverage CLIP's multimodal understandings for medical image classification through Text Proxy Optimization and Multimodal Proxy Learning. Specifically, KPL retrieves image-relevant knowledge descriptions from the constructed knowledge-enhanced base to enrich semantic text proxies. It then harnesses input images and these descriptions, encoded via CLIP, to stably generate multimodal proxies that boost the zero-shot classification performance. Extensive experiments conducted on both medical and natural image datasets demonstrate that KPL enables effective zero-shot image classification, outperforming all baselines. These findings highlight the great potential in this paradigm of mining knowledge from CLIP for medical image classification and broader areas.

Tianxiang Hu, Chenyi Zhou, Jiaxiang Liu et al.

Cell type annotation is a fundamental step in the analysis of single-cell RNA sequencing (scRNA-seq) data. In practice, human experts often rely on the structure revealed by principal component analysis (PCA) followed by $k$-nearest neighbor ($k$-NN) graph construction to guide annotation. While effective, this process is labor-intensive and does not scale to large datasets. Recent advances in CLIP-style models offer a promising path toward automating cell type annotation. By aligning scRNA-seq profiles with natural language descriptions, models like LangCell enable zero-shot annotation. While LangCell demonstrates decent zero-shot performance, its predictions remain suboptimal, particularly in achieving consistent accuracy across all cell types. In this paper, we propose to refine the zero-shot logits produced by LangCell through a graph-regularized optimization framework. By enforcing local consistency over the task-specific PCA-based k-NN graph, our method combines the scalability of the pre-trained models with the structural robustness relied upon in expert annotation. We evaluate our approach on 14 annotated human scRNA-seq datasets from 4 distinct studies, spanning 11 organs and over 200,000 single cells. Our method consistently improves zero-shot annotation accuracy, achieving accuracy gains of up to 10%. Further analysis showcase the mechanism by which GRIT effectively propagates correct signals through the graph, pulling back mislabeled cells toward more accurate predictions. The method is training-free, model-agnostic, and serves as a simple yet effective plug-in for enhancing automated cell type annotation in practice.

Wei Ye, Rui Xie, Jinglei Zhang et al.

Code summarization generates brief natural language description given a source code snippet, while code retrieval fetches relevant source code given a natural language query. Since both tasks aim to model the association between natural language and programming language, recent studies have combined these two tasks to improve their performance. However, researchers have yet been able to effectively leverage the intrinsic connection between the two tasks as they train these tasks in a separate or pipeline manner, which means their performance can not be well balanced. In this paper, we propose a novel end-to-end model for the two tasks by introducing an additional code generation task. More specifically, we explicitly exploit the probabilistic correlation between code summarization and code generation with dual learning, and utilize the two encoders for code summarization and code generation to train the code retrieval task via multi-task learning. We have carried out extensive experiments on an existing dataset of SQL and Python, and results show that our model can significantly improve the results of the code retrieval task over the-state-of-art models, as well as achieve competitive performance in terms of BLEU score for the code summarization task.