Jiahe Qian

Jiahe Qian, Yaoyu Fang, Jinkui Hao et al.

Accurate segmentation of cell nuclei in histopathology images is essential for numerous biomedical research and clinical applications. However, existing cell nucleus segmentation methods only consider a single dataset (i.e., primary domain), while neglecting to leverage supplementary data from diverse sources (i.e., auxiliary domains) to reduce overfitting and enhance the performance. Although incorporating multiple datasets could alleviate overfitting, it often exacerbates performance drops caused by domain shifts. In this work, we introduce Adversarial Multi-domain Alignment of Segment Anything Model (AMA-SAM) that extends the Segment Anything Model (SAM) to overcome these obstacles through two key innovations. First, we propose a Conditional Gradient Reversal Layer (CGRL), a multi-domain alignment module that harmonizes features from diverse domains to promote domain-invariant representation learning while preserving crucial discriminative features for the primary dataset. Second, we address SAM's inherent low-resolution output by designing a High-Resolution Decoder (HR-Decoder), which directly produces fine-grained segmentation maps in order to capture intricate nuclei boundaries in high-resolution histology images. To the best of our knowledge, this is the first attempt to adapt SAM for multi-dataset learning with application to histology nuclei segmentation. We validate our method on several publicly available datasets, demonstrating consistent and significant improvements over state-of-the-art approaches.

Jingze Zhang, Jiahe Qian, Yiliang Zhou et al.

Fact-checking for health-related content is challenging due to the limited availability of annotated training data. In this study, we propose a synthetic data generation pipeline that leverages large language models (LLMs) to augment training data for health-related fact checking. In this pipeline, we summarize source documents, decompose the summaries into atomic facts, and use an LLM to construct sentence-fact entailment tables. From the entailment relations in the table, we further generate synthetic text-claim pairs with binary veracity labels. These synthetic data are then combined with the original data to fine-tune a BERT-based fact-checking model. Evaluation on two public datasets, PubHealth and SciFact, shows that our pipeline improved F1 scores by up to 0.019 and 0.049, respectively, compared to models trained only on the original data. These results highlight the effectiveness of LLM-driven synthetic data augmentation in enhancing the performance of health-related fact-checkers.