Hassan S. Al Khatib

Hassan S. Al Khatib, Subash Neupane, Harish Kumar Manchukonda et al.

Patient-Centric Knowledge Graphs (PCKGs) represent an important shift in healthcare that focuses on individualized patient care by mapping the patient's health information in a holistic and multi-dimensional way. PCKGs integrate various types of health data to provide healthcare professionals with a comprehensive understanding of a patient's health, enabling more personalized and effective care. This literature review explores the methodologies, challenges, and opportunities associated with PCKGs, focusing on their role in integrating disparate healthcare data and enhancing patient care through a unified health perspective. In addition, this review also discusses the complexities of PCKG development, including ontology design, data integration techniques, knowledge extraction, and structured representation of knowledge. It highlights advanced techniques such as reasoning, semantic search, and inference mechanisms essential in constructing and evaluating PCKGs for actionable healthcare insights. We further explore the practical applications of PCKGs in personalized medicine, emphasizing their significance in improving disease prediction and formulating effective treatment plans. Overall, this review provides a foundational perspective on the current state-of-the-art and best practices of PCKGs, guiding future research and applications in this dynamic field.

Noorbakhsh Amiri Golilarz, Hassan S. Al Khatib, Shahram Rahimi

Artificial intelligence has advanced significantly through deep learning, reinforcement learning, and large language and vision models. However, these systems often remain task specific, struggle to adapt to changing conditions, and cannot generalize in ways similar to human cognition. Additionally, they mainly focus on mimicking brain structures, which often leads to black-box models with limited transparency and adaptability. Inspired by the structure and function of biological cognition, this paper introduces the concept of "Neurocognitive-Inspired Intelligence (NII)," a hybrid approach that combines neuroscience, cognitive science, computer vision, and AI to develop more general, adaptive, and robust intelligent systems capable of rapid learning, learning from less data, and leveraging prior experience. These systems aim to emulate the human brain's ability to flexibly learn, reason, remember, perceive, and act in real-world settings with minimal supervision. We review the limitations of current AI methods, define core principles of neurocognitive-inspired intelligence, and propose a modular, biologically inspired architecture that emphasizes integration, embodiment, and adaptability. We also discuss potential implementation strategies and outline various real-world applications, from robotics to education and healthcare. Importantly, this paper offers a hybrid roadmap for future research, laying the groundwork for building AI systems that more closely resemble human cognition.

Hassan S. Al Khatib, Sudip Mittal, Shahram Rahimi et al.

The transition towards patient-centric healthcare necessitates a comprehensive understanding of patient journeys, which encompass all healthcare experiences and interactions across the care spectrum. Existing healthcare data systems are often fragmented and lack a holistic representation of patient trajectories, creating challenges for coordinated care and personalized interventions. Patient Journey Knowledge Graphs (PJKGs) represent a novel approach to addressing the challenge of fragmented healthcare data by integrating diverse patient information into a unified, structured representation. This paper presents a methodology for constructing PJKGs using Large Language Models (LLMs) to process and structure both formal clinical documentation and unstructured patient-provider conversations. These graphs encapsulate temporal and causal relationships among clinical encounters, diagnoses, treatments, and outcomes, enabling advanced temporal reasoning and personalized care insights. The research evaluates four different LLMs, such as Claude 3.5, Mistral, Llama 3.1, and Chatgpt4o, in their ability to generate accurate and computationally efficient knowledge graphs. Results demonstrate that while all models achieved perfect structural compliance, they exhibited variations in medical entity processing and computational efficiency. The paper concludes by identifying key challenges and future research directions. This work contributes to advancing patient-centric healthcare through the development of comprehensive, actionable knowledge graphs that support improved care coordination and outcome prediction.