Navneet Singh

Swati Kumari, Shiva Raj Pokhrel, Swathi Chandrasekhar et al.

Network traffic anomaly detection is a critical cy- bersecurity challenge requiring robust solutions for complex Internet of Things (IoT) environments. We present a novel hybrid quantum-classical framework integrating an enhanced Quantum Support Vector Machine (QSVM) with the Quantum Haar Wavelet Packet Transform (QWPT) for superior anomaly classification under realistic noisy intermediate-scale Quantum conditions. Our methodology employs amplitude-encoded quan- tum state preparation, multi-level QWPT feature extraction, and behavioral analysis via Shannon Entropy profiling and Chi-square testing. Features are classified using QSVM with fidelity-based quantum kernels optimized through hybrid train- ing with simultaneous perturbation stochastic approximation (SPSA) optimizer. Evaluation under noiseless and depolarizing noise conditions demonstrates exceptional performance: 96.67% accuracy on BoT-IoT and 89.67% on IoT-23 datasets, surpassing quantum autoencoder approaches by over 7 percentage points.

Yishu Wei, Adam E. Flanders, Errol Colak et al.

Multimodal large language models have demonstrated comparable performance to that of radiology trainees on multiple-choice board-style exams. However, to develop clinically useful multimodal LLM tools, high-quality benchmarks curated by domain experts are essential. To curate released and holdout datasets of 100 chest radiographic studies each and propose an artificial intelligence (AI)-assisted expert labeling procedure to allow radiologists to label studies more efficiently. A total of 13,735 deidentified chest radiographs and their corresponding reports from the MIDRC were used. GPT-4o extracted abnormal findings from the reports, which were then mapped to 12 benchmark labels with a locally hosted LLM (Phi-4-Reasoning). From these studies, 1,000 were sampled on the basis of the AI-suggested benchmark labels for expert review; the sampling algorithm ensured that the selected studies were clinically relevant and captured a range of difficulty levels. Seventeen chest radiologists participated, and they marked "Agree all", "Agree mostly" or "Disagree" to indicate their assessment of the correctness of the LLM suggested labels. Each chest radiograph was evaluated by three experts. Of these, at least two radiologists selected "Agree All" for 381 radiographs. From this set, 200 were selected, prioritizing those with less common or multiple finding labels, and divided into 100 released radiographs and 100 reserved as the holdout dataset. The holdout dataset is used exclusively by RSNA to independently evaluate different models. A benchmark of 200 chest radiographic studies with 12 benchmark labels was created and made publicly available https://imaging.rsna.org, with each chest radiograph verified by three radiologists. In addition, an AI-assisted labeling procedure was developed to help radiologists label at scale, minimize unnecessary omissions, and support a semicollaborative environment.

Navneet Singh, Shiva Raj Pokhrel

Quantum Machine Learning (QML) continues to evolve, unlocking new opportunities for diverse applications. In this study, we investigate and evaluate the applicability of QML models for binary classification of genome sequence data by employing various feature mapping techniques. We present an open-source, independent Qiskit-based implementation to conduct experiments on a benchmark genomic dataset. Our simulations reveal that the interplay between feature mapping techniques and QML algorithms significantly influences performance. Notably, the Pegasos Quantum Support Vector Classifier (Pegasos-QSVC) exhibits high sensitivity, particularly excelling in recall metrics, while Quantum Neural Networks (QNN) achieve the highest training accuracy across all feature maps. However, the pronounced variability in classifier performance, dependent on feature mapping, highlights the risk of overfitting to localized output distributions in certain scenarios. This work underscores the transformative potential of QML for genomic data classification while emphasizing the need for continued advancements to enhance the robustness and accuracy of these methodologies.

Navneet Singh, Shiva Raj Pokhrel

Quantum Machine Learning (QML) offers significant potential for complex tasks like genome sequence classification, but quantum noise on Noisy Intermediate-Scale Quantum (NISQ) devices poses practical challenges. This study systematically evaluates how various quantum noise models including dephasing, amplitude damping, depolarizing, thermal noise, bit-flip, and phase-flip affect key QML algorithms (QSVC, Peg-QSVC, QNN, VQC) and feature mapping techniques (ZFeatureMap, ZZFeatureMap, and PauliFeatureMap). Results indicate that QSVC is notably robust under noise, whereas Peg-QSVC and QNN are more sensitive, particularly to depolarizing and amplitude-damping noise. The PauliFeatureMap is especially vulnerable, highlighting difficulties in maintaining accurate classification under noisy conditions. These findings underscore the critical importance of feature map selection and noise mitigation strategies in optimizing QML for genomic classification, with promising implications for personalized medicine.

Navneet Singh, Shiva Raj Pokhrel

In this paper, we explore the power of Quantum Machine Learning as we extend, implement and evaluate algorithms like Quantum Support Vector Classifier (QSVC), Pegasos-QSVC, Variational Quantum Circuits (VQC), and Quantum Neural Networks (QNN) in Qiskit with diverse feature mapping techniques for genomic sequence classification.

Swathi Chandrasekhar, Shiva Raj Pokhrel, Swati Kumari et al.

Escalating cyber threats and the high-dimensional complexity of IoT traffic have outpaced classical anomaly detection methods. While deep learning offers improvements, computational bottlenecks limit real-time deployment at scale. We present a quantum autoencoder (QAE) framework that compresses network traffic into discriminative latent representations and employs quantum support vector classification (QSVC) for intrusion detection. Evaluated on three datasets, our approach achieves improved accuracy on ideal simulators and on the IBM Quantum hardware demonstrating practical quantum advantage on current NISQ devices. Crucially, moderate depolarizing noise acts as implicit regularization, stabilizing training and enhancing generalization. This work establishes quantum machine learning as a viable, hardware-ready solution for real-world cybersecurity challenges.

Navneet Singh, Shiva Raj Pokhrel

Trajectory forecasting for autonomous driving must deliver accurate, calibrated multi-modal futures under tight compute and latency constraints. We propose a compact hybrid quantum architecture that aligns quantum inductive bias with road-scene structure by operating in an ego-centric, lane-aligned frame and predicting residual corrections to a kinematic baseline instead of absolute poses. The model combines a transformer-inspired quantum attention encoder (9 qubits), a parameter-lean quantum feedforward stack (64 layers, ${\sim}1200$ trainable angles), and a Fourier-based decoder that uses shallow entanglement and phase superposition to generate 16 trajectory hypotheses in a single pass, with mode confidences derived from the latent spectrum. All circuit parameters are trained with Simultaneous Perturbation Stochastic Approximation (SPSA), avoiding backpropagation through non-analytic components. In the Waymo Open Motion Dataset, the model achieves minADE (minimum Average Displacement Error) of \SI{1.94}{m} and minFDE (minimum Final Displacement Error) of \SI{3.56}{m} in the $16$ models predicted over the horizon of \SI{2.0}{s}, consistently outperforming a kinematic baseline with reduced miss rates and strong recall. Ablations confirm that residual learning in the lane frame, truncated Fourier decoding, shallow entanglement, and spectrum-based ranking focus capacity where it matters, yielding stable optimization and reliable multi-modal forecasts from small, shallow quantum circuits on a modern autonomous-driving benchmark.

Swathi Chandrasekhar, Shiva Raj Pokhrel, Navneet Singh

Accurate prediction of bond dissociation energies (BDEs) underpins mechanistic insight and the rational design of molecules and materials. We present a systematic, reproducible benchmark comparing quantum and classical machine learning models for BDE prediction using a chemically curated feature set encompassing atomic properties (atomic numbers, hybridization), bond characteristics (bond order, type), and local environmental descriptors. Our quantum framework, implemented in Qiskit Aer on six qubits, employs ZZFeatureMap encodings with variational ansatz (RealAmplitudes) across multiple architectures Variational Quantum Regressors (VQR), Quantum Support Vector Regressors (QSVR), Quantum Neural Networks (QNN), Quantum Convolutional Neural Networks (QCNN), and Quantum Random Forests (QRF). These are rigorously benchmarked against strong classical baselines, including Support Vector Regression (SVR), Random Forests (RF), and Multi-Layer Perceptrons (MLP). Comprehensive evaluation spanning absolute and relative error metrics, threshold accuracies, and error distributions shows that top-performing quantum models (QCNN, QRF) match the predictive accuracy and robustness of classical ensembles and deep networks, particularly within the chemically prevalent mid-range BDE regime. These findings establish a transparent baseline for quantum-enhanced molecular property prediction and outline a practical foundation for advancing quantum computational chemistry toward near chemical accuracy.