Xinzhe Luo

Yinsong Wang, Thomas Fletcher, Xinzhe Luo et al.

Reconstructing 3D fetal MR volumes from motion-corrupted stacks of 2D slices is a crucial and challenging task. Conventional slice-to-volume reconstruction (SVR) methods are time-consuming and require multiple orthogonal stacks for reconstruction. While learning-based SVR approaches have significantly reduced the time required at the inference stage, they heavily rely on ground truth information for training, which is inaccessible in practice. To address these challenges, we propose GaussianSVR, a self-supervised framework for slice-to-volume reconstruction. GaussianSVR represents the target volume using 3D Gaussian representations to achieve high-fidelity reconstruction. It leverages a simulated forward slice acquisition model to enable self-supervised training, alleviating the need for ground-truth volumes. Furthermore, to enhance both accuracy and efficiency, we introduce a multi-resolution training strategy that jointly optimizes Gaussian parameters and spatial transformations across different resolution levels. Experiments show that GaussianSVR outperforms the baseline methods on fetal MR volumetric reconstruction. Code will be available upon acceptance.

Siyi Du, Xinzhe Luo, Declan P. O'Regan et al.

Multimodal deep learning (MDL) has achieved remarkable success across various domains, yet its practical deployment is often hindered by incomplete multimodal data. Existing incomplete MDL methods either discard missing modalities, risking the loss of valuable task-relevant information, or recover them, potentially introducing irrelevant noise, leading to the discarding-imputation dilemma. To address this dilemma, in this paper, we propose DyMo, a new inference-time dynamic modality selection framework that adaptively identifies and integrates reliable recovered modalities, fully exploring task-relevant information beyond the conventional discard-or-impute paradigm. Central to DyMo is a novel selection algorithm that maximizes multimodal task-relevant information for each test sample. Since direct estimation of such information at test time is intractable due to the unknown data distribution, we theoretically establish a connection between information and the task loss, which we compute at inference time as a tractable proxy. Building on this, a novel principled reward function is proposed to guide modality selection. In addition, we design a flexible multimodal network architecture compatible with arbitrary modality combinations, alongside a tailored training strategy for robust representation learning. Extensive experiments on diverse natural and medical image datasets show that DyMo significantly outperforms state-of-the-art incomplete/dynamic MDL methods across various missing-data scenarios. Our code is available at https://github.com//siyi-wind/DyMo.

Yinsong Wang, Xinzhe Luo, Siyi Du et al.

Deformable multi-contrast image registration is a challenging yet crucial task due to the complex, non-linear intensity relationships across different imaging contrasts. Conventional registration methods typically rely on iterative optimization of the deformation field, which is time-consuming. Although recent learning-based approaches enable fast and accurate registration during inference, their generalizability remains limited to the specific contrasts observed during training. In this work, we propose an adaptive conditional contrast-agnostic deformable image registration framework (AC-CAR) based on a random convolution-based contrast augmentation scheme. AC-CAR can generalize to arbitrary imaging contrasts without observing them during training. To encourage contrast-invariant feature learning, we propose an adaptive conditional feature modulator (ACFM) that adaptively modulates the features and the contrast-invariant latent regularization to enforce the consistency of the learned feature across different imaging contrasts. Additionally, we enable our framework to provide contrast-agnostic registration uncertainty by integrating a variance network that leverages the contrast-agnostic registration encoder to improve the trustworthiness and reliability of AC-CAR. Experimental results demonstrate that AC-CAR outperforms baseline methods in registration accuracy and exhibits superior generalization to unseen imaging contrasts. Code is available at https://github.com/Yinsong0510/AC-CAR.

Xinzhe Luo, Shuai Shao, Yan Wang et al.

Deep intracranial tumors situated in eloquent brain regions controlling vital functions present critical diagnostic challenges. Clinical practice has shifted toward stereotactic biopsy for pathological confirmation before treatment. Yet biopsy carries inherent risks of hemorrhage and neurological deficits and struggles with sampling bias due to tumor spatial heterogeneity, because pathological changes are typically region-selective rather than tumor-wide. Therefore, advancing non-invasive MRI-based pathology prediction is essential for holistic tumor assessment and modern clinical decision-making. The primary challenge lies in data scarcity: low tumor incidence requires long collection cycles, and annotation demands biopsy-verified pathology from neurosurgical experts. Additionally, tiny lesion volumes lacking segmentation masks cause critical features to be overwhelmed by background noise. To address these challenges, we construct the ICT-MRI dataset - the first public biopsy-verified benchmark with 249 cases across four categories. We propose a Virtual Biopsy framework comprising: MRI-Processor for standardization; Tumor-Localizer employing vision-language models for coarse-to-fine localization via weak supervision; and Adaptive-Diagnoser with a Masked Channel Attention mechanism fusing local discriminative features with global contexts. Experiments demonstrate over 90% accuracy, outperforming baselines by more than 20%.

Shuai Shao, Yan Wang, Shu Jiang et al.

Brain age has become a prominent biomarker of brain health. Yet most prior work targets whole brain age (WBA), a coarse paradigm that struggles to support tasks such as disease characterization and research on development and aging patterns, because relevant changes are typically region-selective rather than brain-wide. Therefore, robust regional brain age (ReBA) estimation is critical, yet a widely generalizable model has yet to be established. In this paper, we propose the Regional Brain Age Prediction Network (ReBA-Pred-Net), a Teacher-Student framework designed for fine-grained brain age estimation. The Teacher produces soft ReBA to guide the Student to yield reliable ReBA estimates with a clinical-prior consistency constraint (regions within the same function should change similarly). For rigorous evaluation, we introduce two indirect metrics: Healthy Control Similarity (HCS), which assesses statistical consistency by testing whether regional brain-age-gap (ReBA minus chronological age) distributions align between training and unseen HC; and Neuro Disease Correlation (NDC), which assesses factual consistency by checking whether clinically confirmed patients show elevated brain-age-gap in disease-associated regions. Experiments across multiple backbones demonstrate the statistical and factual validity of our method.

Jiyao Liu, Junzhi Ning, Chenglong Ma et al.

Despite impressive performance on standard benchmarks, multimodal large language models (MLLMs) face critical challenges in real-world clinical environments where medical images inevitably suffer various quality degradations. Existing benchmarks exhibit two key limitations: (1) absence of large-scale, multidimensional assessment across medical image quality gradients and (2) no systematic confidence calibration analysis. To address these gaps, we present MedQ-Deg, a comprehensive benchmark for evaluating medical MLLMs under image quality degradations. MedQ-Deg provides multi-dimensional evaluation spanning 18 distinct degradation types, 30 fine-grained capability dimensions, and 7 imaging modalities, with 24,894 question-answer pairs. Each degradation is implemented at 3 severity degrees, calibrated by expert radiologists. We further introduce Calibration Shift metric, which quantifies the gap between a model's perceived confidence and actual performance to assess metacognitive reliability under degradation. Our comprehensive evaluation of 40 mainstream MLLMs reveals several critical findings: (1) overall model performance degrades systematically as degradation severity increases, (2) models universally exhibit the AI Dunning-Kruger Effect, maintaining inappropriately high confidence despite severe accuracy collapse, and (3) models display markedly differentiated behavioral patterns across capability dimensions, imaging modalities, and degradation types. We hope MedQ-Deg drives progress toward medical MLLMs that are robust and trustworthy in real clinical practice.