Jie Luo

Zhengliang Liu, Yiwei Li, Peng Shu et al.

This paper introduces Radiology-Llama2, a large language model specialized for radiology through a process known as instruction tuning. Radiology-Llama2 is based on the Llama2 architecture and further trained on a large dataset of radiology reports to generate coherent and clinically useful impressions from radiological findings. Quantitative evaluations using ROUGE metrics on the MIMIC-CXR and OpenI datasets demonstrate that Radiology-Llama2 achieves state-of-the-art performance compared to other generative language models, with a Rouge-1 score of 0.4834 on MIMIC-CXR and 0.4185 on OpenI. Additional assessments by radiology experts highlight the model's strengths in understandability, coherence, relevance, conciseness, and clinical utility. The work illustrates the potential of localized language models designed and tuned for specialized domains like radiology. When properly evaluated and deployed, such models can transform fields like radiology by automating rote tasks and enhancing human expertise.

Haotong Qin, Xudong Ma, Yifu Ding et al.

Deep neural networks, such as the Deep-FSMN, have been widely studied for keyword spotting (KWS) applications while suffering expensive computation and storage. Therefore, network compression technologies like binarization are studied to deploy KWS models on edge. In this paper, we present a strong yet efficient binary neural network for KWS, namely BiFSMNv2, pushing it to the real-network accuracy performance. First, we present a Dual-scale Thinnable 1-bit-Architecture to recover the representation capability of the binarized computation units by dual-scale activation binarization and liberate the speedup potential from an overall architecture perspective. Second, we also construct a Frequency Independent Distillation scheme for KWS binarization-aware training, which distills the high and low-frequency components independently to mitigate the information mismatch between full-precision and binarized representations. Moreover, we propose the Learning Propagation Binarizer, a general and efficient binarizer that enables the forward and backward propagation of binary KWS networks to be continuously improved through learning. We implement and deploy the BiFSMNv2 on ARMv8 real-world hardware with a novel Fast Bitwise Computation Kernel, which is proposed to fully utilize registers and increase instruction throughput. Comprehensive experiments show our BiFSMNv2 outperforms existing binary networks for KWS by convincing margins across different datasets and achieves comparable accuracy with the full-precision networks (only a tiny 1.51% drop on Speech Commands V1-12). We highlight that benefiting from the compact architecture and optimized hardware kernel, BiFSMNv2 can achieve an impressive 25.1x speedup and 20.2x storage-saving on edge hardware.

Lei Huang, Yi Zhou, Tian Wang et al.

Batch normalization (BN) is a milestone technique in deep learning. It normalizes the activation using mini-batch statistics during training but the estimated population statistics during inference. This paper focuses on investigating the estimation of population statistics. We define the estimation shift magnitude of BN to quantitatively measure the difference between its estimated population statistics and expected ones. Our primary observation is that the estimation shift can be accumulated due to the stack of BN in a network, which has detriment effects for the test performance. We further find a batch-free normalization (BFN) can block such an accumulation of estimation shift. These observations motivate our design of XBNBlock that replace one BN with BFN in the bottleneck block of residual-style networks. Experiments on the ImageNet and COCO benchmarks show that XBNBlock consistently improves the performance of different architectures, including ResNet and ResNeXt, by a significant margin and seems to be more robust to distribution shift.

Binxu Li, Tiankai Yan, Yuanting Pan et al.

Multi-Modal Large Language Models (MLLMs), despite being successful, exhibit limited generality and often fall short when compared to specialized models. Recently, LLM-based agents have been developed to address these challenges by selecting appropriate specialized models as tools based on user inputs. However, such advancements have not been extensively explored within the medical domain. To bridge this gap, this paper introduces the first agent explicitly designed for the medical field, named \textbf{M}ulti-modal \textbf{Med}ical \textbf{Agent} (MMedAgent). We curate an instruction-tuning dataset comprising six medical tools solving seven tasks across five modalities, enabling the agent to choose the most suitable tools for a given task. Comprehensive experiments demonstrate that MMedAgent achieves superior performance across a variety of medical tasks compared to state-of-the-art open-source methods and even the closed-source model, GPT-4o. Furthermore, MMedAgent exhibits efficiency in updating and integrating new medical tools. Codes and models are all available.

Xin Yu, Rongye Shi, Pu Feng et al. · cmu

Multi-agent reinforcement learning (MARL) has achieved promising results in recent years. However, most existing reinforcement learning methods require a large amount of data for model training. In addition, data-efficient reinforcement learning requires the construction of strong inductive biases, which are ignored in the current MARL approaches. Inspired by the symmetry phenomenon in multi-agent systems, this paper proposes a framework for exploiting prior knowledge by integrating data augmentation and a well-designed consistency loss into the existing MARL methods. In addition, the proposed framework is model-agnostic and can be applied to most of the current MARL algorithms. Experimental tests on multiple challenging tasks demonstrate the effectiveness of the proposed framework. Moreover, the proposed framework is applied to a physical multi-robot testbed to show its superiority.

Fuda van Diggelen, Jie Luo, Tugay Alperen Karagüzel et al.

Designing controllers for robot swarms is challenging, because human developers have typically no good understanding of the link between the details of a controller that governs individual robots and the swarm behavior that is an indirect result of the interactions between swarm members and the environment. In this paper we investigate whether an evolutionary approach can mitigate this problem. We consider a very challenging task where robots with limited sensing and communication abilities must follow the gradient of an environmental feature and use Differential Evolution to evolve a neural network controller for simulated robots. We conduct a systematic study to measure the flexibility and scalability of the method by varying the size of the arena and number of robots in the swarm. The experiments confirm the feasibility of our approach, the evolved robot controllers induced swarm behavior that solved the task. We found that solutions evolved under the harshest conditions (where the environmental clues were the weakest) were the most flexible and that there is a sweet spot regarding the swarm size. Furthermore, we observed collective motion of the swarm, showcasing truly emergent behavior that was not represented in- and selected for during evolution.

Ailin Huang, Ang Li, Aobo Kong et al.

We introduce Step 3.5 Flash, a sparse Mixture-of-Experts (MoE) model that bridges frontier-level agentic intelligence and computational efficiency. We focus on what matters most when building agents: sharp reasoning and fast, reliable execution. Step 3.5 Flash pairs a 196B-parameter foundation with 11B active parameters for efficient inference. It is optimized with interleaved 3:1 sliding-window/full attention and Multi-Token Prediction (MTP-3) to reduce the latency and cost of multi-round agentic interactions. To reach frontier-level intelligence, we design a scalable reinforcement learning framework that combines verifiable signals with preference feedback, while remaining stable under large-scale off-policy training, enabling consistent self-improvement across mathematics, code, and tool use. Step 3.5 Flash demonstrates strong performance across agent, coding, and math tasks, achieving 85.4% on IMO-AnswerBench, 86.4% on LiveCodeBench-v6 (2024.08-2025.05), 88.2% on tau2-Bench, 69.0% on BrowseComp (with context management), and 51.0% on Terminal-Bench 2.0, comparable to frontier models such as GPT-5.2 xHigh and Gemini 3.0 Pro. By redefining the efficiency frontier, Step 3.5 Flash provides a high-density foundation for deploying sophisticated agents in real-world industrial environments.

Jie Luo, Jakub Tomczak, Karine Miras et al.

The main question this paper addresses is: What combination of a robot controller and a learning method should be used, if the morphology of the learning robot is not known in advance? Our interest is rooted in the context of morphologically evolving modular robots, but the question is also relevant in general, for system designers interested in widely applicable solutions. We perform an experimental comparison of three controller-and-learner combinations: one approach where controllers are based on modelling animal locomotion (Central Pattern Generators, CPG) and the learner is an evolutionary algorithm, a completely different method using Reinforcement Learning (RL) with a neural network controller architecture, and a combination `in-between' where controllers are neural networks and the learner is an evolutionary algorithm. We apply these three combinations to a test suite of modular robots and compare their efficacy, efficiency, and robustness. Surprisingly, the usual CPG-based and RL-based options are outperformed by the in-between combination that is more robust and efficient than the other two setups.

Jie Luo, Karine Miras, Jakub Tomczak et al.

Evolutionary robot systems offer two principal advantages: an advanced way of developing robots through evolutionary optimization and a special research platform to conduct what-if experiments regarding questions about evolution. Our study sits at the intersection of these. We investigate the question ``What if the 18th-century biologist Lamarck was not completely wrong and individual traits learned during a lifetime could be passed on to offspring through inheritance?'' We research this issue through simulations with an evolutionary robot framework where morphologies (bodies) and controllers (brains) of robots are evolvable and robots also can improve their controllers through learning during their lifetime. Within this framework, we compare a Lamarckian system, where learned bits of the brain are inheritable, with a Darwinian system, where they are not. Analyzing simulations based on these systems, we obtain new insights about Lamarckian evolution dynamics and the interaction between evolution and learning. Specifically, we show that Lamarckism amplifies the emergence of `morphological intelligence', the ability of a given robot body to acquire a good brain by learning, and identify the source of this success: `newborn' robots have a higher fitness because their inherited brains match their bodies better than those in a Darwinian system.

Haotong Qin, Xudong Ma, Xingyu Zheng et al.

The LoRA-finetuning quantization of LLMs has been extensively studied to obtain accurate yet compact LLMs for deployment on resource-constrained hardware. However, existing methods cause the quantized LLM to severely degrade and even fail to benefit from the finetuning of LoRA. This paper proposes a novel IR-QLoRA for pushing quantized LLMs with LoRA to be highly accurate through information retention. The proposed IR-QLoRA mainly relies on two technologies derived from the perspective of unified information: (1) statistics-based Information Calibration Quantization allows the quantized parameters of LLM to retain original information accurately; (2) finetuning-based Information Elastic Connection makes LoRA utilizes elastic representation transformation with diverse information. Comprehensive experiments show that IR-QLoRA can significantly improve accuracy across LLaMA and LLaMA2 families under 2-4 bit-widths, e.g., 4- bit LLaMA-7B achieves 1.4% improvement on MMLU compared with the state-of-the-art methods. The significant performance gain requires only a tiny 0.31% additional time consumption, revealing the satisfactory efficiency of our IR-QLoRA. We highlight that IR-QLoRA enjoys excellent versatility, compatible with various frameworks (e.g., NormalFloat and Integer quantization) and brings general accuracy gains. The code is available at https://github.com/htqin/ir-qlora.

Wei Huang, Xingyu Zheng, Xudong Ma et al.

The LLaMA family, a collection of foundation language models ranging from 7B to 65B parameters, has become one of the most powerful open-source large language models (LLMs) and the popular LLM backbone of multi-modal large language models (MLLMs), widely used in computer vision and natural language understanding tasks. In particular, LLaMA3 models have recently been released and have achieved impressive performance in various domains with super-large scale pre-training on over 15T tokens of data. Given the wide application of low-bit quantization for LLMs in resource-constrained scenarios, we explore LLaMA3's capabilities when quantized to low bit-width. This exploration can potentially provide new insights and challenges for the low-bit quantization of LLaMA3 and other future LLMs, especially in addressing performance degradation issues that suffer in LLM compression. Specifically, we comprehensively evaluate the 10 existing post-training quantization and LoRA fine-tuning (LoRA-FT) methods of LLaMA3 on 1-8 bits and various datasets to reveal the low-bit quantization performance of LLaMA3. To uncover the capabilities of low-bit quantized MLLM, we assessed the performance of the LLaMA3-based LLaVA-Next-8B model under 2-4 ultra-low bits with post-training quantization methods. Our experimental results indicate that LLaMA3 still suffers from non-negligible degradation in linguistic and visual contexts, particularly under ultra-low bit widths. This highlights the significant performance gap at low bit-width that needs to be addressed in future developments. We expect that this empirical study will prove valuable in advancing future models, driving LLMs and MLLMs to achieve higher accuracy at lower bit to enhance practicality. Our project is released on https://github.com/Macaronlin/LLaMA3-Quantization , and quantized models are released at https://huggingface.co/Efficient-ML .

Haotong Qin, Xudong Ma, Xianglong Liu et al.

Low-bit quantization is widely used to compress super-resolution (SR) models and reduce storage and computation costs for deployment on resource-limited devices. However, when SR models are pushed to ultra-low precision (2-4 bits), performance can drop sharply due to diminished representational capacity and the detail-sensitive nature of SR. To address these issues, we propose QuantSR+, a unified framework that improves quantization operators, network design, and training optimization, achieving better trade-offs between accuracy and efficiency than prior low-bit SR methods. QuantSR+ mainly relies on three technical contributions: (1) Redistribution-driven Bit Determination (RBD), which reshapes quantization distributions in both forward and backward passes to preserve representation fidelity; (2) Quantized Slimmable Architecture (QSA), which begins with an over-parameterized model and progressively prunes less critical blocks to meet efficiency budgets while pushing the accuracy performance; and (3) Slimming-guided Function-localized Distillation (SFD), which enforces block-aware feature alignment via a direct loss and a progressive, function-local training schedule to capture quantization effects better and speed up convergence. Extensive experiments show that QuantSR+ achieves state-of-the-art performance against both specialized quantized SR methods and generic quantization approaches. For SwinIR-S on Urban100 (x4), it improves PSNR by 0.29 dB over the 2-bit SOTA baseline. Meanwhile, it delivers strong efficiency gains at 2-bit, reducing operations by up to 87.9% and storage by 89.4%. QuantSR+ is effective for both convolutional and transformer-based SR models, indicating broad applicability.

Xingyu Zheng, Yuye Li, Haoran Chu et al.

The Qwen series has emerged as a leading family of open-source Large Language Models (LLMs), demonstrating remarkable capabilities in natural language understanding tasks. With the recent release of Qwen3, which exhibits superior performance across diverse benchmarks, there is growing interest in deploying these models efficiently in resource-constrained environments. Low-bit quantization presents a promising solution, yet its impact on Qwen3's performance remains underexplored. This study conducts a systematic evaluation of Qwen3's robustness under various quantization settings, aiming to uncover both opportunities and challenges in compressing this state-of-the-art model. We rigorously assess 5 existing classic post-training quantization techniques applied to Qwen3, spanning bit-widths from 1 to 8 bits, and evaluate their effectiveness across multiple datasets. Our findings reveal that while Qwen3 maintains competitive performance at moderate bit-widths, it experiences notable degradation in linguistic tasks under ultra-low precision, underscoring the persistent hurdles in LLM compression. These results emphasize the need for further research to mitigate performance loss in extreme quantization scenarios. We anticipate that this empirical analysis will provide actionable insights for advancing quantization methods tailored to Qwen3 and future LLMs, ultimately enhancing their practicality without compromising accuracy. Our project is released on https://github.com/Efficient-ML/Qwen3-Quantization and https://huggingface.co/collections/Efficient-ML/qwen3-quantization-68164450decb1c868788cb2b.

Junlong Jia, Ying Hu, Xi Weng et al.

We present TinyLLaVA Factory, an open-source modular codebase for small-scale large multimodal models (LMMs) with a focus on simplicity of code implementations, extensibility of new features, and reproducibility of training results. Following the design philosophy of the factory pattern in software engineering, TinyLLaVA Factory modularizes the entire system into interchangeable components, with each component integrating a suite of cutting-edge models and methods, meanwhile leaving room for extensions to more features. In addition to allowing users to customize their own LMMs, TinyLLaVA Factory provides popular training recipes to let users pretrain and finetune their models with less coding effort. Empirical experiments validate the effectiveness of our codebase. The goal of TinyLLaVA Factory is to assist researchers and practitioners in exploring the wide landscape of designing and training small-scale LMMs with affordable computational resources.

Yuxin Guo, Yihao Yue, Yunhao Ni et al.

Layer normalization (LN) is a fundamental component in modern deep learning, but its per-sample centering and scaling introduce non-negligible inference overhead. RMSNorm improves efficiency by removing the centering operation, yet this may discard benefits associated with centering. This paper propose a framework to determine whether an LN in an arbitrary DNN can be replaced by RMSNorm without changing the model function. The key idea is to fold LN's centering operation into upstream general linear layers by enforcing zero-mean outputs through the column-centered constraint (CCC) and column-based weight centering (CBWC). We extend the analysis to arbitrary DNNs, define such LNs as foldable LNs, and develop a graph-based detection algorithm. Our analysis shows that many LNs in widely used architectures are foldable, enabling exact inference-time conversion and end-to-end acceleration of 2% to 12% without changing model predictions. Experiments across multiple task families further show that, when exact equivalence is partially broken in practical training settings, our method remains competitive with vanilla LN while improving efficiency.

Hanhui Deng, Xinglin Li, Jie Luo et al.

Electrocardiogram is a useful diagnostic signal that can detect cardiac abnormalities by measuring the electrical activity generated by the heart. Due to its rapid, non-invasive, and richly informative characteristics, ECG has many emerging applications. In this paper, we study novel deep learning technologies to effectively manage and analyse ECG data, with the aim of building a diagnostic model, accurately and quickly, that can substantially reduce the burden on medical workers. Unlike the existing ECG models that exhibit a high misdiagnosis rate, our deep learning approaches can automatically extract the features of ECG data through end-to-end training. Specifically, we first devise EfficientECG, an accurate and lightweight classification model for ECG analysis based on the existing EfficientNet model, which can effectively handle high-frequency long-sequence ECG data with various leading types. On top of that, we next propose a cross-attention-based feature fusion model of EfficientECG for analysing multi-lead ECG data with multiple features (e.g., gender and age). Our evaluations on representative ECG datasets validate the superiority of our model against state-of-the-art works in terms of high precision, multi-feature fusion, and lightweights.

Baichuan Zhou, Ying Hu, Xi Weng et al.

We present the TinyLLaVA framework that provides a unified perspective in designing and analyzing the small-scale Large Multimodal Models (LMMs). We empirically study the effects of different vision encoders, connection modules, language models, training data and training recipes. Our extensive experiments showed that better quality of data combined with better training recipes, smaller LMMs can consistently achieve on-par performances compared to bigger LMMs. Under our framework, we train a family of small-scale LMMs. Our best model, TinyLLaVA-3.1B, achieves better overall performance against existing 7B models such as LLaVA-1.5 and Qwen-VL. We hope our findings can serve as baselines for future research in terms of data scaling, training setups and model selections. Our model weights and codes will be made public.

Xi Weng, Yunhao Ni, Tengwei Song et al.

Whitening loss offers a theoretical guarantee against feature collapse in self-supervised learning (SSL) with joint embedding architectures. Typically, it involves a hard whitening approach, transforming the embedding and applying loss to the whitened output. In this work, we introduce Spectral Transformation (ST), a framework to modulate the spectrum of embedding and to seek for functions beyond whitening that can avoid dimensional collapse. We show that whitening is a special instance of ST by definition, and our empirical investigations unveil other ST instances capable of preventing collapse. Additionally, we propose a novel ST instance named IterNorm with trace loss (INTL). Theoretical analysis confirms INTL's efficacy in preventing collapse and modulating the spectrum of embedding toward equal-eigenvalues during optimization. Our experiments on ImageNet classification and COCO object detection demonstrate INTL's potential in learning superior representations. The code is available at https://github.com/winci-ai/INTL.

Haotong Qin, Xudong Ma, Yifu Ding et al.

The deep neural networks, such as the Deep-FSMN, have been widely studied for keyword spotting (KWS) applications. However, computational resources for these networks are significantly constrained since they usually run on-call on edge devices. In this paper, we present BiFSMN, an accurate and extreme-efficient binary neural network for KWS. We first construct a High-frequency Enhancement Distillation scheme for the binarization-aware training, which emphasizes the high-frequency information from the full-precision network's representation that is more crucial for the optimization of the binarized network. Then, to allow the instant and adaptive accuracy-efficiency trade-offs at runtime, we also propose a Thinnable Binarization Architecture to further liberate the acceleration potential of the binarized network from the topology perspective. Moreover, we implement a Fast Bitwise Computation Kernel for BiFSMN on ARMv8 devices which fully utilizes registers and increases instruction throughput to push the limit of deployment efficiency. Extensive experiments show that BiFSMN outperforms existing binarization methods by convincing margins on various datasets and is even comparable with the full-precision counterpart (e.g., less than 3% drop on Speech Commands V1-12). We highlight that benefiting from the thinnable architecture and the optimized 1-bit implementation, BiFSMN can achieve an impressive 22.3x speedup and 15.5x storage-saving on real-world edge hardware. Our code is released at https://github.com/htqin/BiFSMN.

Jean-Baptiste Carluer, Laurent Chauvin, Jie Luo et al.

This work details a highly efficient implementation of the 3D scale-invariant feature transform (SIFT) algorithm, for the purpose of machine learning from large sets of volumetric medical image data. The primary operations of the 3D SIFT code are implemented on a graphics processing unit (GPU), including convolution, sub-sampling, and 4D peak detection from scale-space pyramids. The performance improvements are quantified in keypoint detection and image-to-image matching experiments, using 3D MRI human brain volumes of different people. Computationally efficient 3D keypoint descriptors are proposed based on the Binary Robust Independent Elementary Feature (BRIEF) code, including a novel descriptor we call Ranked Robust Independent Elementary Features (RRIEF), and compared to the original 3D SIFT-Rank method\citep{toews2013efficient}. The GPU implementation affords a speedup of approximately 7X beyond an optimised CPU implementation, where computation time is reduced from 1.4 seconds to 0.2 seconds for 3D volumes of size (145, 174, 145) voxels with approximately 3000 keypoints. Notable speedups include the convolution operation (20X), 4D peak detection (3X), sub-sampling (3X), and difference-of-Gaussian pyramid construction (2X). Efficient descriptors offer a speedup of 2X and a memory savings of 6X compared to standard SIFT-Rank descriptors, at a cost of reduced numbers of keypoint correspondences, revealing a trade-off between computational efficiency and algorithmic performance. The speedups gained by our implementation will allow for a more efficient analysis on larger data sets. Our optimized GPU implementation of the 3D SIFT-Rank extractor is available at https://github.com/CarluerJB/3D_SIFT_CUDA.

StepFun, Bin Wang, Bojun Wang et al.

Large language models (LLMs) face low hardware efficiency during decoding, especially for long-context reasoning tasks. This paper introduces Step-3, a 321B-parameter VLM with hardware-aware model-system co-design optimized for minimizing decoding costs. Step-3 innovates in two key dimensions: (1) A novel Multi-Matrix Factorization Attention (MFA) mechanism that significantly reduces both KV cache size and computation while maintaining high attention expressiveness, and (2) Attention-FFN Disaggregation (AFD), a distributed inference system that decouples attention and Feed-Forward Network (FFN) layers into specialized subsystems. This co-design achieves unprecedented cost efficiency: Step-3 significantly reduces theoretical decoding costs compared with models like DeepSeek-V3 and Qwen3 MoE 235B, with the gains widening at longer context. Step-3 achieves low cost while activating 38B parameters per token (more than DeepSeek-V3 and Qwen3 MoE 235B), demonstrating that hardware-aligned attention arithmetic intensity, MoE sparsity, and AFD are critical to cost-effectiveness. We perform a head-to-head comparison with DeepSeek-V3 in its favorable scenarios. Our implementation on Hopper GPUs achieves a decoding throughput of up to 4,039 tokens per second per GPU under 50ms TPOT SLA (4K context, FP8, no MTP). It is higher than DeepSeek-V3's 2,324 in the same setup and sets a new Pareto frontier for LLM decoding.

Jie Luo

Evolutionary robotics offers a powerful framework for designing and evolving robot morphologies, particularly in the context of modular robots. However, the role of query mechanisms during the genotype-to-phenotype mapping process has been largely overlooked. This research addresses this gap by conducting a comparative analysis of query mechanisms in the brain-body co-evolution of modular robots. Using two different query mechanisms, Breadth-First Search (BFS) and Random Query, within the context of evolving robot morphologies using CPPNs and robot controllers using tensors, and testing them in two evolutionary frameworks, Lamarckian and Darwinian systems, this study investigates their influence on evolutionary outcomes and performance. The findings demonstrate the impact of the two query mechanisms on the evolution and performance of modular robot bodies, including morphological intelligence, diversity, and morphological traits. This study suggests that BFS is both more effective and efficient in producing highly performing robots. It also reveals that initially, robot diversity was higher with BFS compared to Random Query, but in the Lamarckian system, it declines faster, converging to superior designs, while in the Darwinian system, BFS led to higher end-process diversity.

Wentao Chen, Xichen Xu, Jie Luo et al.

Image-to-image translation is a common task in computer vision and has been rapidly increasing the impact on the field of medical imaging. Deep learning-based methods that employ conditional generative adversarial networks (cGANs), such as Pix2PixGAN, have been extensively explored to perform image-to-image translation tasks. However, when noisy medical image data are considered, such methods cannot be directly applied to produce clean images. Recently, an augmented GAN architecture named AmbientGAN has been proposed that can be trained on noisy measurement data to synthesize high-quality clean medical images. Inspired by AmbientGAN, in this work, we propose a new cGAN architecture, Ambient-Pix2PixGAN, for performing medical image-to-image translation tasks by use of noisy measurement data. Numerical studies that consider MRI-to-PET translation are conducted. Both traditional image quality metrics and task-based image quality metrics are employed to assess the proposed Ambient-Pix2PixGAN. It is demonstrated that our proposed Ambient-Pix2PixGAN can be successfully trained on noisy measurement data to produce high-quality translated images in target imaging modality.

Xi Weng, Jianing An, Xudong Ma et al.

Self-supervised learning (SSL) methods via joint embedding architectures have proven remarkably effective at capturing semantically rich representations with strong clustering properties, magically in the absence of label supervision. Despite this, few of them have explored leveraging these untapped properties to improve themselves. In this paper, we provide an evidence through various metrics that the encoder's output $encoding$ exhibits superior and more stable clustering properties compared to other components. Building on this insight, we propose a novel positive-feedback SSL method, termed Representation Self-Assignment (ReSA), which leverages the model's clustering properties to promote learning in a self-guided manner. Extensive experiments on standard SSL benchmarks reveal that models pretrained with ReSA outperform other state-of-the-art SSL methods by a significant margin. Finally, we analyze how ReSA facilitates better clustering properties, demonstrating that it effectively enhances clustering performance at both fine-grained and coarse-grained levels, shaping representations that are inherently more structured and semantically meaningful.

Haotong Qin, Xianglong Liu, Xudong Ma et al.

Deep neural networks for real-time video matting suffer significant computational limitations on edge devices, hindering their adoption in widespread applications such as online conferences and short-form video production. Binarization emerges as one of the most common compression approaches with compact 1-bit parameters and efficient bitwise operations. However, accuracy and efficiency limitations exist in the binarized video matting network due to its degenerated encoder and redundant decoder. Following a theoretical analysis based on the information bottleneck principle, the limitations are mainly caused by the degradation of prediction-relevant information in the intermediate features and the redundant computation in prediction-irrelevant areas. We present BiVM, an accurate and resource-efficient Binarized neural network for Video Matting. First, we present a series of binarized computation structures with elastic shortcuts and evolvable topologies, enabling the constructed encoder backbone to extract high-quality representation from input videos for accurate prediction. Second, we sparse the intermediate feature of the binarized decoder by masking homogeneous parts, allowing the decoder to focus on representation with diverse details while alleviating the computation burden for efficient inference. Furthermore, we construct a localized binarization-aware mimicking framework with the information-guided strategy, prompting matting-related representation in full-precision counterparts to be accurately and fully utilized. Comprehensive experiments show that the proposed BiVM surpasses alternative binarized video matting networks, including state-of-the-art (SOTA) binarization methods, by a substantial margin. Moreover, our BiVM achieves significant savings of 14.3x and 21.6x in computation and storage costs, respectively. We also evaluate BiVM on ARM CPU hardware.

Yahao Shi, Yang Liu, Yanmin Wu et al.

We propose DriveAnyMesh, a method for driving mesh guided by monocular video. Current 4D generation techniques encounter challenges with modern rendering engines. Implicit methods have low rendering efficiency and are unfriendly to rasterization-based engines, while skeletal methods demand significant manual effort and lack cross-category generalization. Animating existing 3D assets, instead of creating 4D assets from scratch, demands a deep understanding of the input's 3D structure. To tackle these challenges, we present a 4D diffusion model that denoises sequences of latent sets, which are then decoded to produce mesh animations from point cloud trajectory sequences. These latent sets leverage a transformer-based variational autoencoder, simultaneously capturing 3D shape and motion information. By employing a spatiotemporal, transformer-based diffusion model, information is exchanged across multiple latent frames, enhancing the efficiency and generalization of the generated results. Our experimental results demonstrate that DriveAnyMesh can rapidly produce high-quality animations for complex motions and is compatible with modern rendering engines. This method holds potential for applications in both the gaming and filming industries.

Tengwei Song, Xudong Ma, Yang Liu et al.

We focus on obtaining robust knowledge graph embedding under perturbation in the embedding space. To address these challenges, we introduce a novel framework, Robust Knowledge Graph Embedding via Denoising, which enhances the robustness of KGE models on noisy triples. By treating KGE methods as energy-based models, we leverage the established connection between denoising and score matching, enabling the training of a robust denoising KGE model. Furthermore, we propose certified robustness evaluation metrics for KGE methods based on the concept of randomized smoothing. Through comprehensive experiments on benchmark datasets, our framework consistently shows superior performance compared to existing state-of-the-art KGE methods when faced with perturbed entity embedding.

Le Luo, Bingrong Xu, Qingyong Zhang et al.

By using unsupervised domain adaptation (UDA), knowledge can be transferred from a label-rich source domain to a target domain that contains relevant information but lacks labels. Many existing UDA algorithms suffer from directly using raw images as input, resulting in models that overly focus on redundant information and exhibit poor generalization capability. To address this issue, we attempt to improve the performance of unsupervised domain adaptation by employing the Fourier method (FTF).Specifically, FTF is inspired by the amplitude of Fourier spectra, which primarily preserves low-level statistical information. In FTF, we effectively incorporate low-level information from the target domain into the source domain by fusing the amplitudes of both domains in the Fourier domain. Additionally, we observe that extracting features from batches of images can eliminate redundant information while retaining class-specific features relevant to the task. Building upon this observation, we apply the Fourier Transform at the data stream level for the first time. To further align multiple sources of data, we introduce the concept of correlation alignment. To evaluate the effectiveness of our FTF method, we conducted evaluations on four benchmark datasets for domain adaptation, including Office-31, Office-Home, ImageCLEF-DA, and Office-Caltech. Our results demonstrate superior performance.

Jie Luo, Yuxuan Jiang, Xin Jin et al.

Semantic segmentation serves as a cornerstone of scene understanding in autonomous driving but continues to face significant challenges under complex conditions such as occlusion. Light field and LiDAR modalities provide complementary visual and spatial cues that are beneficial for robust perception; however, their effective integration is hindered by limited viewpoint diversity and inherent modality discrepancies. To address these challenges, the first multimodal semantic segmentation dataset integrating light field data and point cloud data is proposed. Based on this dataset, we proposed a multi-modal light field point-cloud fusion segmentation network(Mlpfseg), incorporating feature completion and depth perception to segment both camera images and LiDAR point clouds simultaneously. The feature completion module addresses the density mismatch between point clouds and image pixels by performing differential reconstruction of point-cloud feature maps, enhancing the fusion of these modalities. The depth perception module improves the segmentation of occluded objects by reinforcing attention scores for better occlusion awareness. Our method outperforms image-only segmentation by 1.71 Mean Intersection over Union(mIoU) and point cloud-only segmentation by 2.38 mIoU, demonstrating its effectiveness.

Simin Li, Zheng Yuwei, Zihao Mao et al.

Partial agent failure becomes inevitable when systems scale up, making it crucial to identify the subset of agents whose compromise would most severely degrade overall performance. In this paper, we study this Vulnerable Agent Identification (VAI) problem in large-scale multi-agent reinforcement learning (MARL). We frame VAI as a Hierarchical Adversarial Decentralized Mean Field Control (HAD-MFC), where the upper level involves an NP-hard combinatorial task of selecting the most vulnerable agents, and the lower level learns worst-case adversarial policies for these agents using mean-field MARL. The two problems are coupled together, making HAD-MFC difficult to solve. To solve this, we first decouple the hierarchical process by Fenchel-Rockafellar transform, resulting a regularized mean-field Bellman operator for upper level that enables independent learning at each level, thus reducing computational complexity. We then reformulate the upper-level combinatorial problem as a MDP with dense rewards from our regularized mean-field Bellman operator, enabling us to sequentially identify the most vulnerable agents by greedy and RL algorithms. This decomposition provably preserves the optimal solution of the original HAD-MFC. Experiments show our method effectively identifies more vulnerable agents in large-scale MARL and the rule-based system, fooling system into worse failures, and learns a value function that reveals the vulnerability of each agent.

Yongkai Tian, Yirong Qi, Xin Yu et al.

In robotic systems, the performance of reinforcement learning depends on the rationality of predefined reward functions. However, manually designed reward functions often lead to policy failures due to inaccuracies. Inverse Reinforcement Learning (IRL) addresses this problem by inferring implicit reward functions from expert demonstrations. Nevertheless, existing methods rely heavily on large amounts of expert demonstrations to accurately recover the reward function. The high cost of collecting expert demonstrations in robotic applications, particularly in multi-robot systems, severely hinders the practical deployment of IRL. Consequently, improving sample efficiency has emerged as a critical challenge in multi-agent inverse reinforcement learning (MIRL). Inspired by the symmetry inherent in multi-agent systems, this work theoretically demonstrates that leveraging symmetry enables the recovery of more accurate reward functions. Building upon this insight, we propose a universal framework that integrates symmetry into existing multi-agent adversarial IRL algorithms, thereby significantly enhancing sample efficiency. Experimental results from multiple challenging tasks have demonstrated the effectiveness of this framework. Further validation in physical multi-robot systems has shown the practicality of our method.

Luyang Jiang, Jianing An, Jie Luo et al.

We propose Visual-only Question Answering (VoQA), a novel multimodal task in which questions are visually embedded within images, without any accompanying textual input. This requires models to locate, recognize, and reason over visually embedded textual questions, posing challenges for existing large vision-language models (LVLMs), which show notable performance drops even with carefully designed prompts. To bridge this gap, we introduce Guided Response Triggering Supervised Fine-tuning (GRT-SFT), a structured fine-tuning strategy that guides the model to perform step-by-step reasoning purely based on visual input, significantly improving model performance. Our work enhances models' capacity for human-like visual understanding in complex multimodal scenarios, where information, including language, is perceived visually.

Jiaxiang Li, Junwei Feng, Jie Luo et al.

Machine learning interatomic potentials have revolutionized complex materials design by enabling rapid exploration of material configurational spaces via crystal structure prediction with ab initio accuracy. However, critical challenges persist in ensuring robust generalization to unknown structures and minimizing the requirement for substantial expert knowledge and time-consuming manual interventions. Here, we propose an automated crystal structure prediction framework built upon the attention-coupled neural networks potential to address these limitations. The generalizability of the potential is achieved by sampling regions across the local minima of the potential energy surface, where the self-evolving pipeline autonomously refines the potential iteratively while minimizing human intervention. The workflow is validated on Mg-Ca-H ternary and Be-P-N-O quaternary systems by exploring nearly 10 million configurations, demonstrating substantial speedup compared to first-principles calculations. These results underscore the effectiveness of our approach in accelerating the exploration and discovery of complex multi-component functional materials.

Wenyu Zhang, Jie Luo, Xinming Zhang et al.

With the explosive growth of multimodal content online, pre-trained visual-language models have shown great potential for multimodal recommendation. However, while these models achieve decent performance when applied in a frozen manner, surprisingly, due to significant domain gaps (e.g., feature distribution discrepancy and task objective misalignment) between pre-training and personalized recommendation, adopting a joint training approach instead leads to performance worse than baseline. Existing approaches either rely on simple feature extraction or require computationally expensive full model fine-tuning, struggling to balance effectiveness and efficiency. To tackle these challenges, we propose \textbf{P}arameter-efficient \textbf{T}uning for \textbf{M}ultimodal \textbf{Rec}ommendation (\textbf{PTMRec}), a novel framework that bridges the domain gap between pre-trained models and recommendation systems through a knowledge-guided dual-stage parameter-efficient training strategy. This framework not only eliminates the need for costly additional pre-training but also flexibly accommodates various parameter-efficient tuning methods.

Jie Luo, Karine Miras, Carlo Longhi et al.

This study explores the integration of Lamarckian system into evolutionary robotics (ER), comparing it with the traditional Darwinian model across various environments. By adopting Lamarckian principles, where robots inherit learned traits, alongside Darwinian learning without inheritance, we investigate adaptation in dynamic settings. Our research, conducted in six distinct environmental setups, demonstrates that Lamarckian systems outperform Darwinian ones in adaptability and efficiency, particularly in challenging conditions. Our analysis highlights the critical role of the interplay between controller \& morphological evolution and environment adaptation, with parent-offspring similarities and newborn \&survivors before and after learning providing insights into the effectiveness of trait inheritance. Our findings suggest Lamarckian principles could significantly advance autonomous system design, highlighting the potential for more adaptable and robust robotic solutions in complex, real-world applications. These theoretical insights were validated using real physical robots, bridging the gap between simulation and practical application.

Wentao Chen, Jiwei Li, Xichen Xu et al.

[$^{18}$F]fluorodeoxyglucose (FDG) positron emission tomography (PET) has emerged as a crucial tool in identifying the epileptic focus, especially in cases where magnetic resonance imaging (MRI) diagnosis yields indeterminate results. FDG PET can provide the metabolic information of glucose and help identify abnormal areas that are not easily found through MRI. However, the effectiveness of FDG PET-based assessment and diagnosis depends on the selection of a healthy control group. The healthy control group typically consists of healthy individuals similar to epilepsy patients in terms of age, gender, and other aspects for providing normal FDG PET data, which will be used as a reference for enhancing the accuracy and reliability of the epilepsy diagnosis. However, significant challenges arise when a healthy PET control group is unattainable. Yaakub \emph{et al.} have previously introduced a Pix2PixGAN-based method for MRI to PET translation. This method used paired MRI and FDG PET scans from healthy individuals for training, and produced pseudo normal FDG PET images from patient MRIs that are subsequently used for lesion detection. However, this approach requires a large amount of high-quality, paired MRI and PET images from healthy control subjects, which may not always be available. In this study, we investigated unsupervised learning methods for unpaired MRI to PET translation for generating pseudo normal FDG PET for epileptic focus localization. Two deep learning methods, CycleGAN and SynDiff, were employed, and we found that diffusion-based method achieved improved performance in accurately localizing the epileptic focus.

Jie Luo, Aart Stuurman, Jakub M. Tomczak et al.

Simultaneously evolving morphologies (bodies) and controllers (brains) of robots can cause a mismatch between the inherited body and brain in the offspring. To mitigate this problem, the addition of an infant learning period by the so-called Triangle of Life framework has been proposed relatively long ago. However, an empirical assessment is still lacking to-date. In this paper we investigate the effects of such a learning mechanism from different perspectives. Using extensive simulations we show that learning can greatly increase task performance and reduce the number of generations required to reach a certain fitness level compared to the purely evolutionary approach. Furthermore, although learning only directly affects the controllers, we demonstrate that the evolved morphologies will be also different. This provides a quantitative demonstration that changes in the brain can induce changes in the body. Finally, we examine the concept of morphological intelligence quantified by the ability of a given body to learn. We observe that the learning delta, the performance difference between the inherited and the learned brain, is growing throughout the evolutionary process. This shows that evolution is producing robots with an increasing plasticity, that is, consecutive generations are becoming better and better learners which in turn makes them better and better at the given task. All in all, our results demonstrate that the Triangle of Life is not only a concept of theoretical interest, but a system architecture with practical benefits.

Tengwei Song, Jie Luo, Lei Huang

Knowledge graph embedding models learn the representations of entities and relations in the knowledge graphs for predicting missing links (relations) between entities. Their effectiveness are deeply affected by the ability of modeling and inferring different relation patterns such as symmetry, asymmetry, inversion, composition and transitivity. Although existing models are already able to model many of these relations patterns, transitivity, a very common relation pattern, is still not been fully supported. In this paper, we first theoretically show that the transitive relations can be modeled with projections. We then propose the Rot-Pro model which combines the projection and relational rotation together. We prove that Rot-Pro can infer all the above relation patterns. Experimental results show that the proposed Rot-Pro model effectively learns the transitivity pattern and achieves the state-of-the-art results on the link prediction task in the datasets containing transitive relations.

Zhe Xu, Yixin Wang, Donghuan Lu et al.

Semi-supervised learning has substantially advanced medical image segmentation since it alleviates the heavy burden of acquiring the costly expert-examined annotations. Especially, the consistency-based approaches have attracted more attention for their superior performance, wherein the real labels are only utilized to supervise their paired images via supervised loss while the unlabeled images are exploited by enforcing the perturbation-based \textit{"unsupervised"} consistency without explicit guidance from those real labels. However, intuitively, the expert-examined real labels contain more reliable supervision signals. Observing this, we ask an unexplored but interesting question: can we exploit the unlabeled data via explicit real label supervision for semi-supervised training? To this end, we discard the previous perturbation-based consistency but absorb the essence of non-parametric prototype learning. Based on the prototypical network, we then propose a novel cyclic prototype consistency learning (CPCL) framework, which is constructed by a labeled-to-unlabeled (L2U) prototypical forward process and an unlabeled-to-labeled (U2L) backward process. Such two processes synergistically enhance the segmentation network by encouraging more discriminative and compact features. In this way, our framework turns previous \textit{"unsupervised"} consistency into new \textit{"supervised"} consistency, obtaining the \textit{"all-around real label supervision"} property of our method. Extensive experiments on brain tumor segmentation from MRI and kidney segmentation from CT images show that our CPCL can effectively exploit the unlabeled data and outperform other state-of-the-art semi-supervised medical image segmentation methods.

Jie Luo, Daan Zeeuwe, Agoston E. Eiben

When controllers (brains) and morphologies (bodies) of robots simultaneously evolve, this can lead to a problem, namely the brain & body mismatch problem. In this research, we propose a solution of lifetime learning. We set up a system where modular robots can create offspring that inherit the bodies of parents by recombination and mutation. With regards to the brains of the offspring, we use two methods to create them. The first one entails solely evolution which means the brain of a robot child is inherited from its parents. The second approach is evolution plus learning which means the brain of a child is inherited as well, but additionally is developed by a learning algorithm - RevDEknn. We compare these two methods by running experiments in a simulator called Revolve and use efficiency, efficacy, and the morphology intelligence of the robots for the comparison. The experiments show that the evolution plus learning method does not only lead to a higher fitness level, but also to more morphologically evolving robots. This constitutes a quantitative demonstration that changes in the brain can induce changes in the body, leading to the concept of morphological intelligence, which is quantified by the learning delta, meaning the ability of a morphology to facilitate learning.

Zhe Xu, Jie Luo, Donghuan Lu et al.

In order to tackle the difficulty associated with the ill-posed nature of the image registration problem, regularization is often used to constrain the solution space. For most learning-based registration approaches, the regularization usually has a fixed weight and only constrains the spatial transformation. Such convention has two limitations: (i) Besides the laborious grid search for the optimal fixed weight, the regularization strength of a specific image pair should be associated with the content of the images, thus the "one value fits all" training scheme is not ideal; (ii) Only spatially regularizing the transformation may neglect some informative clues related to the ill-posedness. In this study, we propose a mean-teacher based registration framework, which incorporates an additional temporal consistency regularization term by encouraging the teacher model's prediction to be consistent with that of the student model. More importantly, instead of searching for a fixed weight, the teacher enables automatically adjusting the weights of the spatial regularization and the temporal consistency regularization by taking advantage of the transformation uncertainty and appearance uncertainty. Extensive experiments on the challenging abdominal CT-MRI registration show that our training strategy can promisingly advance the original learning-based method in terms of efficient hyperparameter tuning and a better tradeoff between accuracy and smoothness.

Yixin Wang, Zihao Lin, Zhe Xu et al.

Medical imaging plays a pivotal role in diagnosis and treatment in clinical practice. Inspired by the significant progress in automatic image captioning, various deep learning (DL)-based methods have been proposed to generate radiology reports for medical images. Despite promising results, previous works overlook the uncertainties of their models and are thus unable to provide clinicians with the reliability/confidence of the generated radiology reports to assist their decision-making. In this paper, we propose a novel method to explicitly quantify both the visual uncertainty and the textual uncertainty for DL-based radiology report generation. Such multi-modal uncertainties can sufficiently capture the model confidence degree at both the report level and the sentence level, and thus they are further leveraged to weight the losses for more comprehensive model optimization. Experimental results have demonstrated that the proposed method for model uncertainty characterization and estimation can produce more reliable confidence scores for radiology report generation, and the modified loss function, which takes into account the uncertainties, leads to better model performance on two public radiology report datasets. In addition, the quality of the automatically generated reports was manually evaluated by human raters and the results also indicate that the proposed uncertainties can reflect the variance of clinical diagnosis.

Zhe Xu, Donghuan Lu, Yixin Wang et al.

Manually segmenting the hepatic vessels from Computer Tomography (CT) is far more expertise-demanding and laborious than other structures due to the low-contrast and complex morphology of vessels, resulting in the extreme lack of high-quality labeled data. Without sufficient high-quality annotations, the usual data-driven learning-based approaches struggle with deficient training. On the other hand, directly introducing additional data with low-quality annotations may confuse the network, leading to undesirable performance degradation. To address this issue, we propose a novel mean-teacher-assisted confident learning framework to robustly exploit the noisy labeled data for the challenging hepatic vessel segmentation task. Specifically, with the adapted confident learning assisted by a third party, i.e., the weight-averaged teacher model, the noisy labels in the additional low-quality dataset can be transformed from "encumbrance" to "treasure" via progressive pixel-wise soft-correction, thus providing productive guidance. Extensive experiments using two public datasets demonstrate the superiority of the proposed framework as well as the effectiveness of each component.

Zhe Xu, Jiangpeng Yan, Jie Luo et al.

Multimodal image registration (MIR) is a fundamental procedure in many image-guided therapies. Recently, unsupervised learning-based methods have demonstrated promising performance over accuracy and efficiency in deformable image registration. However, the estimated deformation fields of the existing methods fully rely on the to-be-registered image pair. It is difficult for the networks to be aware of the mismatched boundaries, resulting in unsatisfactory organ boundary alignment. In this paper, we propose a novel multimodal registration framework, which leverages the deformation fields estimated from both: (i) the original to-be-registered image pair, (ii) their corresponding gradient intensity maps, and adaptively fuses them with the proposed gated fusion module. With the help of auxiliary gradient-space guidance, the network can concentrate more on the spatial relationship of the organ boundary. Experimental results on two clinically acquired CT-MRI datasets demonstrate the effectiveness of our proposed approach.

Zhe Xu, Jiangpeng Yan, Jie Luo et al.

The loss function of an unsupervised multimodal image registration framework has two terms, i.e., a metric for similarity measure and regularization. In the deep learning era, researchers proposed many approaches to automatically learn the similarity metric, which has been shown effective in improving registration performance. However, for the regularization term, most existing multimodal registration approaches still use a hand-crafted formula to impose artificial properties on the estimated deformation field. In this work, we propose a unimodal cyclic regularization training pipeline, which learns task-specific prior knowledge from simpler unimodal registration, to constrain the deformation field of multimodal registration. In the experiment of abdominal CT-MR registration, the proposed method yields better results over conventional regularization methods, especially for severely deformed local regions.

Zhe Xu, Jie Luo, Jiangpeng Yan et al.

Deformable image registration (DIR) is essential for many image-guided therapies. Recently, deep learning approaches have gained substantial popularity and success in DIR. Most deep learning approaches use the so-called mono-stream "high-to-low, low-to-high" network structure, and can achieve satisfactory overall registration results. However, accurate alignments for some severely deformed local regions, which are crucial for pinpointing surgical targets, are often overlooked. Consequently, these approaches are not sensitive to some hard-to-align regions, e.g., intra-patient registration of deformed liver lobes. In this paper, we propose a novel unsupervised registration network, namely the Full-Resolution Residual Registration Network (F3RNet), for deformable registration of severely deformed organs. The proposed method combines two parallel processing streams in a residual learning fashion. One stream takes advantage of the full-resolution information that facilitates accurate voxel-level registration. The other stream learns the deep multi-scale residual representations to obtain robust recognition. We also factorize the 3D convolution to reduce the training parameters and enhance network efficiency. We validate the proposed method on a clinically acquired intra-patient abdominal CT-MRI dataset and a public inspiratory and expiratory thorax CT dataset. Experiments on both multimodal and unimodal registration demonstrate promising results compared to state-of-the-art approaches.

Zhe Xu, Jie Luo, Jiangpeng Yan et al.

Deformable image registration between Computed Tomography (CT) images and Magnetic Resonance (MR) imaging is essential for many image-guided therapies. In this paper, we propose a novel translation-based unsupervised deformable image registration method. Distinct from other translation-based methods that attempt to convert the multimodal problem (e.g., CT-to-MR) into a unimodal problem (e.g., MR-to-MR) via image-to-image translation, our method leverages the deformation fields estimated from both: (i) the translated MR image and (ii) the original CT image in a dual-stream fashion, and automatically learns how to fuse them to achieve better registration performance. The multimodal registration network can be effectively trained by computationally efficient similarity metrics without any ground-truth deformation. Our method has been evaluated on two clinical datasets and demonstrates promising results compared to state-of-the-art traditional and learning-based methods.

Jie Luo, Guangshen Ma, Sarah Frisken et al.

With the increasing availability of new image registration approaches, an unbiased evaluation is becoming more needed so that clinicians can choose the most suitable approaches for their applications. Current evaluations typically use landmarks in manually annotated datasets. As a result, the quality of annotations is crucial for unbiased comparisons. Even though most data providers claim to have quality control over their datasets, an objective third-party screening can be reassuring for intended users. In this study, we use the variogram to screen the manually annotated landmarks in two datasets used to benchmark registration in image-guided neurosurgeries. The variogram provides an intuitive 2D representation of the spatial characteristics of annotated landmarks. Using variograms, we identified potentially problematic cases and had them examined by experienced radiologists. We found that (1) a small number of annotations may have fiducial localization errors; (2) the landmark distribution for some cases is not ideal to offer fair comparisons. If unresolved, both findings could incur bias in registration evaluation.

Bin Wen, Jie Luo, Xianglong Liu et al.

Extracting graph representation of visual scenes in image is a challenging task in computer vision. Although there has been encouraging progress of scene graph generation in the past decade, we surprisingly find that the performance of existing approaches is largely limited by the strong biases, which mainly stem from (1) unconsciously assuming relations with certain semantic properties such as symmetric and (2) imbalanced annotations over different relations. To alleviate the negative effects of these biases, we proposed a new and simple architecture named Rich and Fair semantic extraction network (RiFa for short), to not only capture rich semantic properties of the relations, but also fairly predict relations with different scale of annotations. Using pseudo-siamese networks, RiFa embeds the subject and object respectively to distinguish their semantic differences and meanwhile preserve their underlying semantic properties. Then, it further predicts subject-object relations based on both the visual and semantic features of entities under certain contextual area, and fairly ranks the relation predictions for those with a few annotations. Experiments on the popular Visual Genome dataset show that RiFa achieves state-of-the-art performance under several challenging settings of scene graph task. Especially, it performs significantly better on capturing different semantic properties of relations, and obtains the best overall per relation performance.

Siming Bayer, Ute Spiske, Jie Luo et al.

For a wide range of clinical applications, such as adaptive treatment planning or intraoperative image update, feature-based deformable registration (FDR) approaches are widely employed because of their simplicity and low computational complexity. FDR algorithms estimate a dense displacement field by interpolating a sparse field, which is given by the established correspondence between selected features. In this paper, we consider the deformation field as a Gaussian Process (GP), whereas the selected features are regarded as prior information on the valid deformations. Using GP, we are able to estimate the both dense displacement field and a corresponding uncertainty map at once. Furthermore, we evaluated the performance of different hyperparameter settings for squared exponential kernels with synthetic, phantom and clinical data respectively. The quantitative comparison shows, GP-based interpolation has performance on par with state-of-the-art B-spline interpolation. The greatest clinical benefit of GP-based interpolation is that it gives a reliable estimate of the mathematical uncertainty of the calculated dense displacement map.