Sonia Koszut

Zhiyu Wang, Sonia Koszut, Pietro Liò et al.

The integration of multi-omics single-cell data remains challenging due to high-dimensionality and complex inter-modality relationships. To address this, we introduce MoRE-GNN (Multi-omics Relational Edge Graph Neural Network), a heterogeneous graph autoencoder that combines graph convolution and attention mechanisms to dynamically construct relational graphs directly from data. Evaluations on six publicly available datasets demonstrate that MoRE-GNN captures biologically meaningful relationships and outperforms existing methods, particularly in settings with strong inter-modality correlations. Furthermore, the learned representations allow for accurate downstream cross-modal predictions. While performance may vary with dataset complexity, MoRE-GNN offers an adaptive, scalable and interpretable framework for advancing multi-omics integration.

Sonia Koszut, Sam Nallaperuma-Herzberg, Pietro Lio

Stress significantly contributes to both mental and physical disorders, yet traditional self-reported questionnaires are inherently subjective. In this study, we introduce a novel framework that employs geometric machine learning to detect stress from raw EEG recordings. Our approach constructs graphs by integrating structural connectivity (derived from electrode spatial arrangement) with functional connectivity from pairwise signal correlations. A spatio-temporal graph convolutional network (ST-GCN) processes these graphs to capture spatial and temporal dynamics. Experiments on the SAM-40 dataset show that the ST-GCN outperforms standard machine learning models on all key classification metrics and enhances interpretability, explored through ablation analyses of key channels and brain regions. These results pave the way for more objective and accurate stress detection methods.