CTIS-QA: Clinical Template-Informed Slide-level Question Answering for PathologyHao Lu, Ziniu Qian, Yifu Li et al.
In this paper, we introduce a clinical diagnosis template-based pipeline to systematically collect and structure pathological information. In collaboration with pathologists and guided by the the College of American Pathologists (CAP) Cancer Protocols, we design a Clinical Pathology Report Template (CPRT) that ensures comprehensive and standardized extraction of diagnostic elements from pathology reports. We validate the effectiveness of our pipeline on TCGA-BRCA. First, we extract pathological features from reports using CPRT. These features are then used to build CTIS-Align, a dataset of 80k slide-description pairs from 804 WSIs for vision-language alignment training, and CTIS-Bench, a rigorously curated VQA benchmark comprising 977 WSIs and 14,879 question-answer pairs. CTIS-Bench emphasizes clinically grounded, closed-ended questions (e.g., tumor grade, receptor status) that reflect real diagnostic workflows, minimize non-visual reasoning, and require genuine slide understanding. We further propose CTIS-QA, a Slide-level Question Answering model, featuring a dual-stream architecture that mimics pathologists' diagnostic approach. One stream captures global slide-level context via clustering-based feature aggregation, while the other focuses on salient local regions through attention-guided patch perception module. Extensive experiments on WSI-VQA, CTIS-Bench, and slide-level diagnostic tasks show that CTIS-QA consistently outperforms existing state-of-the-art models across multiple metrics. Code and data are available at https://github.com/HLSvois/CTIS-QA.
9.8CVJan 5
NextFlow: Unified Sequential Modeling Activates Multimodal Understanding and GenerationHuichao Zhang, Liao Qu, Yiheng Liu et al.
We present NextFlow, a unified decoder-only autoregressive transformer trained on 6 trillion interleaved text-image discrete tokens. By leveraging a unified vision representation within a unified autoregressive architecture, NextFlow natively activates multimodal understanding and generation capabilities, unlocking abilities of image editing, interleaved content and video generation. Motivated by the distinct nature of modalities - where text is strictly sequential and images are inherently hierarchical - we retain next-token prediction for text but adopt next-scale prediction for visual generation. This departs from traditional raster-scan methods, enabling the generation of 1024x1024 images in just 5 seconds - orders of magnitude faster than comparable AR models. We address the instabilities of multi-scale generation through a robust training recipe. Furthermore, we introduce a prefix-tuning strategy for reinforcement learning. Experiments demonstrate that NextFlow achieves state-of-the-art performance among unified models and rivals specialized diffusion baselines in visual quality.
1.4LGJan 2
Explainability-Guided Defense: Attribution-Aware Model Refinement Against Adversarial Data AttacksLongwei Wang, Mohammad Navid Nayyem, Abdullah Al Rakin et al.
The growing reliance on deep learning models in safety-critical domains such as healthcare and autonomous navigation underscores the need for defenses that are both robust to adversarial perturbations and transparent in their decision-making. In this paper, we identify a connection between interpretability and robustness that can be directly leveraged during training. Specifically, we observe that spurious, unstable, or semantically irrelevant features identified through Local Interpretable Model-Agnostic Explanations (LIME) contribute disproportionately to adversarial vulnerability. Building on this insight, we introduce an attribution-guided refinement framework that transforms LIME from a passive diagnostic into an active training signal. Our method systematically suppresses spurious features using feature masking, sensitivity-aware regularization, and adversarial augmentation in a closed-loop refinement pipeline. This approach does not require additional datasets or model architectures and integrates seamlessly into standard adversarial training. Theoretically, we derive an attribution-aware lower bound on adversarial distortion that formalizes the link between explanation alignment and robustness. Empirical evaluations on CIFAR-10, CIFAR-10-C, and CIFAR-100 demonstrate substantial improvements in adversarial robustness and out-of-distribution generalization.
11.1CVJan 4
DrivingGen: A Comprehensive Benchmark for Generative Video World Models in Autonomous DrivingYang Zhou, Hao Shao, Letian Wang et al.
Video generation models, as one form of world models, have emerged as one of the most exciting frontiers in AI, promising agents the ability to imagine the future by modeling the temporal evolution of complex scenes. In autonomous driving, this vision gives rise to driving world models: generative simulators that imagine ego and agent futures, enabling scalable simulation, safe testing of corner cases, and rich synthetic data generation. Yet, despite fast-growing research activity, the field lacks a rigorous benchmark to measure progress and guide priorities. Existing evaluations remain limited: generic video metrics overlook safety-critical imaging factors; trajectory plausibility is rarely quantified; temporal and agent-level consistency is neglected; and controllability with respect to ego conditioning is ignored. Moreover, current datasets fail to cover the diversity of conditions required for real-world deployment. To address these gaps, we present DrivingGen, the first comprehensive benchmark for generative driving world models. DrivingGen combines a diverse evaluation dataset curated from both driving datasets and internet-scale video sources, spanning varied weather, time of day, geographic regions, and complex maneuvers, with a suite of new metrics that jointly assess visual realism, trajectory plausibility, temporal coherence, and controllability. Benchmarking 14 state-of-the-art models reveals clear trade-offs: general models look better but break physics, while driving-specific ones capture motion realistically but lag in visual quality. DrivingGen offers a unified evaluation framework to foster reliable, controllable, and deployable driving world models, enabling scalable simulation, planning, and data-driven decision-making.