Julia Chen

Manqing Mao, Paishun Ting, Yijian Xiang et al.

Recent advancements in large language models (LLMs) have provided a new avenue for chatbot development. Most existing research, however, has primarily centered on single-user chatbots that determine "What" to answer. This paper highlights the complexity of multi-user chatbots, introducing the 3W design dimensions: "What" to say, "When" to respond, and "Who" to answer. Additionally, we proposed Multi-User Chat Assistant (MUCA), an LLM-based framework tailored for group discussions. MUCA consists of three main modules: Sub-topic Generator, Dialog Analyzer, and Conversational Strategies Arbitrator. These modules jointly determine suitable response contents, timings, and appropriate addressees. This paper further proposes an LLM-based Multi-User Simulator (MUS) to ease MUCA's optimization, enabling faster simulation of conversations between the chatbot and simulated users, and speeding up MUCA's early development. In goal-oriented conversations with a small to medium number of participants, MUCA demonstrates effectiveness in tasks like chiming in at appropriate timings, generating relevant content, and improving user engagement, as shown by case studies and user studies.

Piumi Sandarenu, Julia Chen, Iveta Slapetova et al.

Advancements in digital imaging technologies have sparked increased interest in using multiplexed immunofluorescence (mIF) images to visualise and identify the interactions between specific immunophenotypes with the tumour microenvironment at the cellular level. Current state-of-the-art multiplexed immunofluorescence image analysis pipelines depend on cell feature representations characterised by morphological and stain intensity-based metrics generated using simple statistical and machine learning-based tools. However, these methods are not capable of generating complex representations of cells. We propose a deep learning-based cell feature extraction model using a variational autoencoder with supervision using a latent subspace to extract cell features in mIF images. We perform cell phenotype classification using a cohort of more than 44,000 multiplexed immunofluorescence cell image patches extracted across 1,093 tissue microarray cores of breast cancer patients, to demonstrate the success of our model against current and alternative methods.