Juhee Lee

Soochul Park, Yeon Ju Lee, SeongJin Yoon et al.

Diffusion probabilistic models (DPMs) are widely adopted for their outstanding generative fidelity, yet their sampling is computationally demanding. Polynomial-based multistep samplers mitigate this cost by accelerating inference; however, despite their theoretical accuracy guarantees, they generate the sampling trajectory according to a predefined scheme, providing no flexibility for further optimization. To address this limitation, we propose RBF-Solver, a multistep diffusion sampler that interpolates model evaluations with Gaussian radial basis functions (RBFs). By leveraging learnable shape parameters in Gaussian RBFs, RBF-Solver explicitly follows optimal sampling trajectories. At first order, it reduces to the Euler method (DDIM). At second order or higher, as the shape parameters approach infinity, RBF-Solver converges to the Adams method, ensuring its compatibility with existing samplers. Owing to the locality of Gaussian RBFs, RBF-Solver maintains high image fidelity even at fourth order or higher, where previous samplers deteriorate. For unconditional generation, RBF-Solver consistently outperforms polynomial-based samplers in the high-NFE regime (NFE >= 15). On CIFAR-10 with the Score-SDE model, it achieves an FID of 2.87 with 15 function evaluations and further improves to 2.48 with 40 function evaluations. For conditional ImageNet 256 x 256 generation with the Guided Diffusion model at a guidance scale 8.0, substantial gains are achieved in the low-NFE range (5-10), yielding a 16.12-33.73% reduction in FID relative to polynomial-based samplers.

Akhil Vaid, Joshua Lampert, Juhee Lee et al.

Generative Large Language Models (LLMs) hold significant promise in healthcare, demonstrating capabilities such as passing medical licensing exams and providing clinical knowledge. However, their current use as information retrieval tools is limited by challenges like data staleness, resource demands, and occasional generation of incorrect information. This study assessed the potential of LLMs to function as autonomous agents in a simulated tertiary care medical center, using real-world clinical cases across multiple specialties. Both proprietary and open-source LLMs were evaluated, with Retrieval Augmented Generation (RAG) enhancing contextual relevance. Proprietary models, particularly GPT-4, generally outperformed open-source models, showing improved guideline adherence and more accurate responses with RAG. The manual evaluation by expert clinicians was crucial in validating models' outputs, underscoring the importance of human oversight in LLM operation. Further, the study emphasizes Natural Language Programming (NLP) as the appropriate paradigm for modifying model behavior, allowing for precise adjustments through tailored prompts and real-world interactions. This approach highlights the potential of LLMs to significantly enhance and supplement clinical decision-making, while also emphasizing the value of continuous expert involvement and the flexibility of NLP to ensure their reliability and effectiveness in healthcare settings.