William Berman

Alexander Peysakhovich, William Berman

Consider an auto-regressive model that produces outputs x (e.g., answers to questions, molecules) each of which can be summarized by an attribute vector y (e.g., helpfulness vs. harmlessness, or bio-availability vs. lipophilicity). An arbitrary reward function r(y) encodes tradeoffs between these properties. Typically, tilting the model's sampling distribution to increase this reward is done at training time via reinforcement learning. However, if the reward function changes, re-alignment requires re-training. In this paper, we show that a reward weighted classifier-free guidance (RCFG) can act as a policy improvement operator in this setting, approximating tilting the sampling distribution by the Q function. We apply RCFG to molecular generation, demonstrating that it can optimize novel reward functions at test time. Finally, we show that using RCFG as a teacher and distilling into the base policy to serve as a warm start significantly speeds up convergence for standard RL.

Suraj Patil, William Berman, Robin Rombach et al.

We present aMUSEd, an open-source, lightweight masked image model (MIM) for text-to-image generation based on MUSE. With 10 percent of MUSE's parameters, aMUSEd is focused on fast image generation. We believe MIM is under-explored compared to latent diffusion, the prevailing approach for text-to-image generation. Compared to latent diffusion, MIM requires fewer inference steps and is more interpretable. Additionally, MIM can be fine-tuned to learn additional styles with only a single image. We hope to encourage further exploration of MIM by demonstrating its effectiveness on large-scale text-to-image generation and releasing reproducible training code. We also release checkpoints for two models which directly produce images at 256x256 and 512x512 resolutions.

Alexander Peysakhovich, William Berman, Joseph Rufo et al.

Cell painting is a popular technique for creating human-interpretable, high-contrast images of cell morphology. There are two major issues with cell paint: (1) it is labor-intensive and (2) it requires chemical fixation, making the study of cell dynamics impossible. We train a diffusion model (Morphological Observation Neural Enhancement Tool, or MONET) on a large dataset to predict cell paint channels from brightfield images. We show that model quality improves with scale. The model uses a consistency architecture to generate time-lapse videos, despite the impossibility of obtaining cell paint video training data. In addition, we show that this architecture enables a form of in-context learning, allowing the model to partially transfer to out-of-distribution cell lines and imaging protocols. Virtual cell painting is not intended to replace physical cell painting completely, but to act as a complementary tool enabling novel workflows in biological research.

William Berman, Alexander Peysakhovich

We train a model to generate images from multimodal prompts of interleaved text and images such as "a <picture of a man> man and his <picture of a dog> dog in an <picture of a cartoon> animated style." We bootstrap a multimodal dataset by extracting semantically meaningful image crops corresponding to words in the image captions of synthetically generated and publicly available text-image data. Our model, MUMU, is composed of a vision-language model encoder with a diffusion decoder and is trained on a single 8xH100 GPU node. Despite being only trained on crops from the same image, MUMU learns to compose inputs from different images into a coherent output. For example, an input of a realistic person and a cartoon will output the same person in the cartoon style, and an input of a standing subject and a scooter will output the subject riding the scooter. As a result, our model generalizes to tasks such as style transfer and character consistency. Our results show the promise of using multimodal models as general purpose controllers for image generation.