Baptiste Goujaud

h-index2
2papers
107citations

2 Papers

43.3LGMar 20, 2019Code
Gradient based sample selection for online continual learning

Rahaf Aljundi, Min Lin, Baptiste Goujaud et al.

A continual learning agent learns online with a non-stationary and never-ending stream of data. The key to such learning process is to overcome the catastrophic forgetting of previously seen data, which is a well known problem of neural networks. To prevent forgetting, a replay buffer is usually employed to store the previous data for the purpose of rehearsal. Previous works often depend on task boundary and i.i.d. assumptions to properly select samples for the replay buffer. In this work, we formulate sample selection as a constraint reduction problem based on the constrained optimization view of continual learning. The goal is to select a fixed subset of constraints that best approximate the feasible region defined by the original constraints. We show that it is equivalent to maximizing the diversity of samples in the replay buffer with parameters gradient as the feature. We further develop a greedy alternative that is cheap and efficient. The advantage of the proposed method is demonstrated by comparing to other alternatives under the continual learning setting. Further comparisons are made against state of the art methods that rely on task boundaries which show comparable or even better results for our method.

1.2APDec 21, 2017
Robust Detection of Covariate-Treatment Interactions in Clinical Trials

Baptiste Goujaud, Eric W. Tramel, Pierre Courtiol et al.

Detection of interactions between treatment effects and patient descriptors in clinical trials is critical for optimizing the drug development process. The increasing volume of data accumulated in clinical trials provides a unique opportunity to discover new biomarkers and further the goal of personalized medicine, but it also requires innovative robust biomarker detection methods capable of detecting non-linear, and sometimes weak, signals. We propose a set of novel univariate statistical tests, based on the theory of random walks, which are able to capture non-linear and non-monotonic covariate-treatment interactions. We also propose a novel combined test, which leverages the power of all of our proposed univariate tests into a single general-case tool. We present results for both synthetic trials as well as real-world clinical trials, where we compare our method with state-of-the-art techniques and demonstrate the utility and robustness of our approach.