Che Liu

Che Liu, Sibo Cheng, Miaojing Shi et al.

In the field of medical Vision-Language Pre-training (VLP), significant efforts have been devoted to deriving text and image features from both clinical reports and associated medical images. However, most existing methods may have overlooked the opportunity in leveraging the inherent hierarchical structure of clinical reports, which are generally split into `findings' for descriptive content and `impressions' for conclusive observation. Instead of utilizing this rich, structured format, current medical VLP approaches often simplify the report into either a unified entity or fragmented tokens. In this work, we propose a novel clinical prior guided VLP framework named IMITATE to learn the structure information from medical reports with hierarchical vision-language alignment. The framework derives multi-level visual features from the chest X-ray (CXR) images and separately aligns these features with the descriptive and the conclusive text encoded in the hierarchical medical report. Furthermore, a new clinical-informed contrastive loss is introduced for cross-modal learning, which accounts for clinical prior knowledge in formulating sample correlations in contrastive learning. The proposed model, IMITATE, outperforms baseline VLP methods across six different datasets, spanning five medical imaging downstream tasks. Comprehensive experimental results highlight the advantages of integrating the hierarchical structure of medical reports for vision-language alignment. The code related to this paper is available at https://github.com/cheliu-computation/IMITATE-TMI2024.

Che Liu, Rui Wang, Junfeng Jiang et al.

In this paper, we introduce the task of learning unsupervised dialogue embeddings. Trivial approaches such as combining pre-trained word or sentence embeddings and encoding through pre-trained language models (PLMs) have been shown to be feasible for this task. However, these approaches typically ignore the conversational interactions between interlocutors, resulting in poor performance. To address this issue, we proposed a self-guided contrastive learning approach named dial2vec. Dial2vec considers a dialogue as an information exchange process. It captures the conversational interaction patterns between interlocutors and leverages them to guide the learning of the embeddings corresponding to each interlocutor. The dialogue embedding is obtained by an aggregation of the embeddings from all interlocutors. To verify our approach, we establish a comprehensive benchmark consisting of six widely-used dialogue datasets. We consider three evaluation tasks: domain categorization, semantic relatedness, and dialogue retrieval. Dial2vec achieves on average 8.7, 9.0, and 13.8 points absolute improvements in terms of purity, Spearman's correlation, and mean average precision (MAP) over the strongest baseline on the three tasks respectively. Further analysis shows that dial2vec obtains informative and discriminative embeddings for both interlocutors under the guidance of the conversational interactions and achieves the best performance when aggregating them through the interlocutor-level pooling strategy. All codes and data are publicly available at https://github.com/AlibabaResearch/DAMO-ConvAI/tree/main/dial2vec.

Che Liu, Anand Shah, Wenjia Bai et al.

Medical Vision-Language Pre-training (VLP) learns representations jointly from medical images and paired radiology reports. It typically requires large-scale paired image-text datasets to achieve effective pre-training for both the image encoder and text encoder. The advent of text-guided generative models raises a compelling question: Can VLP be implemented solely with synthetic images generated from genuine radiology reports, thereby mitigating the need for extensively pairing and curating image-text datasets? In this work, we scrutinize this very question by examining the feasibility and effectiveness of employing synthetic images for medical VLP. We replace real medical images with their synthetic equivalents, generated from authentic medical reports. Utilizing three state-of-the-art VLP algorithms, we exclusively train on these synthetic samples. Our empirical evaluation across three subsequent tasks, namely image classification, semantic segmentation and object detection, reveals that the performance achieved through synthetic data is on par with or even exceeds that obtained with real images. As a pioneering contribution to this domain, we introduce a large-scale synthetic medical image dataset, paired with anonymized real radiology reports. This alleviates the need of sharing medical images, which are not easy to curate and share in practice. The code and the dataset can be found in \href{https://github.com/cheliu-computation/MedSyn-RepLearn/tree/main}{https://github.com/cheliu-computation/MedSyn-RepLearn/tree/main}.

Sibo Cheng, Cesar Quilodran-Casas, Said Ouala et al.

Data Assimilation (DA) and Uncertainty quantification (UQ) are extensively used in analysing and reducing error propagation in high-dimensional spatial-temporal dynamics. Typical applications span from computational fluid dynamics (CFD) to geoscience and climate systems. Recently, much effort has been given in combining DA, UQ and machine learning (ML) techniques. These research efforts seek to address some critical challenges in high-dimensional dynamical systems, including but not limited to dynamical system identification, reduced order surrogate modelling, error covariance specification and model error correction. A large number of developed techniques and methodologies exhibit a broad applicability across numerous domains, resulting in the necessity for a comprehensive guide. This paper provides the first overview of the state-of-the-art researches in this interdisciplinary field, covering a wide range of applications. This review aims at ML scientists who attempt to apply DA and UQ techniques to improve the accuracy and the interpretability of their models, but also at DA and UQ experts who intend to integrate cutting-edge ML approaches to their systems. Therefore, this article has a special focus on how ML methods can overcome the existing limits of DA and UQ, and vice versa. Some exciting perspectives of this rapidly developing research field are also discussed.

Yuchong Sun, Che Liu, Kun Zhou et al.

Humans often interact with large language models (LLMs) in multi-turn interaction to obtain desired answers or more information. However, most existing studies overlook the multi-turn instruction following ability of LLMs, in terms of training dataset, training method, and evaluation benchmark. In this paper, we introduce Parrot, a solution aiming to enhance multi-turn instruction following for LLMs. First, we introduce an efficient but effective method for collecting multi-turn instructions that feature human-like queries, such as anaphora and ellipsis. Second, we propose a context-aware preference optimization strategy to further enhance LLMs for complex queries in multi-turn interaction. Moreover, to quantitatively evaluate LLMs in multi-turn instruction following, we manually build a multi-turn benchmark derived from existing ones. Extensive experiments show that Parrot improves current LLMs by up to 7.2% in multi-turn instruction following. Our dataset and codes will be open-sourced to facilitate future research.

Che Liu, Sibo Cheng, Chen Chen et al.

Medical vision-language models enable co-learning and integrating features from medical imaging and clinical text. However, these models are not easy to train and the latent representation space can be complex. Here we propose a novel way for pre-training and regularising medical vision-language models. The proposed method, named Medical vision-language pre-training with Frozen language models and Latent spAce Geometry optimization (M-FLAG), leverages a frozen language model for training stability and efficiency and introduces a novel orthogonality loss to harmonize the latent space geometry. We demonstrate the potential of the pre-trained model on three downstream tasks: medical image classification, segmentation, and object detection. Extensive experiments across five public datasets demonstrate that M-FLAG significantly outperforms existing medical vision-language pre-training approaches and reduces the number of parameters by 78\%. Notably, M-FLAG achieves outstanding performance on the segmentation task while using only 1\% of the RSNA dataset, even outperforming ImageNet pre-trained models that have been fine-tuned using 100\% of the data.

Yinda Chen, Che Liu, Wei Huang et al.

Vision-Language Pretraining (VLP) has demonstrated remarkable capabilities in learning visual representations from textual descriptions of images without annotations. Yet, effective VLP demands large-scale image-text pairs, a resource that suffers scarcity in the medical domain. Moreover, conventional VLP is limited to 2D images while medical images encompass diverse modalities, often in 3D, making the learning process more challenging. To address these challenges, we present Generative Text-Guided 3D Vision-Language Pretraining for Unified Medical Image Segmentation (GTGM), a framework that extends of VLP to 3D medical images without relying on paired textual descriptions. Specifically, GTGM utilizes large language models (LLM) to generate medical-style text from 3D medical images. This synthetic text is then used to supervise 3D visual representation learning. Furthermore, a negative-free contrastive learning objective strategy is introduced to cultivate consistent visual representations between augmented 3D medical image patches, which effectively mitigates the biases associated with strict positive-negative sample pairings. We evaluate GTGM on three imaging modalities - Computed Tomography (CT), Magnetic Resonance Imaging (MRI), and electron microscopy (EM) over 13 datasets. GTGM's superior performance across various medical image segmentation tasks underscores its effectiveness and versatility, by enabling VLP extension into 3D medical imagery while bypassing the need for paired text.

Tianbao Xie, Fan Zhou, Zhoujun Cheng et al.

Language agents show potential in being capable of utilizing natural language for varied and intricate tasks in diverse environments, particularly when built upon large language models (LLMs). Current language agent frameworks aim to facilitate the construction of proof-of-concept language agents while neglecting the non-expert user access to agents and paying little attention to application-level designs. We present OpenAgents, an open platform for using and hosting language agents in the wild of everyday life. OpenAgents includes three agents: (1) Data Agent for data analysis with Python/SQL and data tools; (2) Plugins Agent with 200+ daily API tools; (3) Web Agent for autonomous web browsing. OpenAgents enables general users to interact with agent functionalities through a web user interface optimized for swift responses and common failures while offering developers and researchers a seamless deployment experience on local setups, providing a foundation for crafting innovative language agents and facilitating real-world evaluations. We elucidate the challenges and opportunities, aspiring to set a foundation for future research and development of real-world language agents.

Sibo Cheng, Che Liu, Yike Guo et al.

Variational Data Assimilation (DA) has been broadly used in engineering problems for field reconstruction and prediction by performing a weighted combination of multiple sources of noisy data. In recent years, the integration of deep learning (DL) techniques in DA has shown promise in improving the efficiency and accuracy in high-dimensional dynamical systems. Nevertheless, existing deep DA approaches face difficulties in dealing with unstructured observation data, especially when the placement and number of sensors are dynamic over time. We introduce a novel variational DA scheme, named Voronoi-tessellation Inverse operator for VariatIonal Data assimilation (VIVID), that incorporates a DL inverse operator into the assimilation objective function. By leveraging the capabilities of the Voronoi-tessellation and convolutional neural networks, VIVID is adept at handling sparse, unstructured, and time-varying sensor data. Furthermore, the incorporation of the DL inverse operator establishes a direct link between observation and state space, leading to a reduction in the number of minimization steps required for DA. Additionally, VIVID can be seamlessly integrated with Proper Orthogonal Decomposition (POD) to develop an end-to-end reduced-order DA scheme, which can further expedite field reconstruction. Numerical experiments in a fluid dynamics system demonstrate that VIVID can significantly outperform existing DA and DL algorithms. The robustness of VIVID is also accessed through the application of various levels of prior error, the utilization of varying numbers of sensors, and the misspecification of error covariance in DA.

Sibo Cheng, Jinyang Min, Che Liu et al.

Data assimilation techniques are often confronted with challenges handling complex high dimensional physical systems, because high precision simulation in complex high dimensional physical systems is computationally expensive and the exact observation functions that can be applied in these systems are difficult to obtain. It prompts growing interest in integrating deep learning models within data assimilation workflows, but current software packages for data assimilation cannot handle deep learning models inside. This study presents a novel Python package seamlessly combining data assimilation with deep neural networks to serve as models for state transition and observation functions. The package, named TorchDA, implements Kalman Filter, Ensemble Kalman Filter (EnKF), 3D Variational (3DVar), and 4D Variational (4DVar) algorithms, allowing flexible algorithm selection based on application requirements. Comprehensive experiments conducted on the Lorenz 63 and a two-dimensional shallow water system demonstrate significantly enhanced performance over standalone model predictions without assimilation. The shallow water analysis validates data assimilation capabilities mapping between different physical quantity spaces in either full space or reduced order space. Overall, this innovative software package enables flexible integration of deep learning representations within data assimilation, conferring a versatile tool to tackle complex high dimensional dynamical systems across scientific domains.

Jiao Ou, Junda Lu, Che Liu et al.

Large language models (LLMs) have achieved remarkable breakthroughs in new dialogue capabilities by leveraging instruction tuning, which refreshes human impressions of dialogue systems. The long-standing goal of dialogue systems is to be human-like enough to establish long-term connections with users. Therefore, there has been an urgent need to evaluate LLMs as human-like dialogue systems. In this paper, we propose DialogBench, a dialogue evaluation benchmark that contains 12 dialogue tasks to probe the capabilities of LLMs as human-like dialogue systems should have. Specifically, we prompt GPT-4 to generate evaluation instances for each task. We first design the basic prompt based on widely used design principles and further mitigate the existing biases to generate higher-quality evaluation instances. Our extensive tests on English and Chinese DialogBench of 26 LLMs show that instruction tuning improves the human likeness of LLMs to a certain extent, but most LLMs still have much room for improvement as human-like dialogue systems. Interestingly, results also show that the positioning of assistant AI can make instruction tuning weaken the human emotional perception of LLMs and their mastery of information about human daily life.

Yihong Tang, Jiao Ou, Che Liu et al.

Role-playing is an emerging application in the field of Human-Computer Interaction (HCI), primarily implemented through the alignment training of a large language model (LLM) with assigned characters. Despite significant progress, role-playing agents (RPLAs) still struggle with maintaining role-consistency across conversations, particularly when confronted with boundary queries subtly related to character attributes. In this paper, we present ERABAL, a framework aimed at enhancing RPLAs' role-playing capabilities through boundary-aware learning. ERABAL encompasses a generation pipeline for role-specific dialogues and a concomitant methodology for alignment training. Through comprehensive evaluations, we demonstrate that ERABAL is both efficient and effective. By training with significantly fewer dialogues than those used in leading approaches, ERABAL achieves notable improvements across WikiRoleEval, CharacterEval, and the role-playing subset of MT-Bench compared to the generalist baseline models. Our code and datasets will be made publicly available to support further research.

Yinda Chen, Che Liu, Xiaoyu Liu et al.

The burgeoning integration of 3D medical imaging into healthcare has led to a substantial increase in the workload of medical professionals. To assist clinicians in their diagnostic processes and alleviate their workload, the development of a robust system for retrieving similar case studies presents a viable solution. While the concept holds great promise, the field of 3D medical text-image retrieval is currently limited by the absence of robust evaluation benchmarks and curated datasets. To remedy this, our study presents a groundbreaking dataset, {BIMCV-R}, which includes an extensive collection of 8,069 3D CT volumes, encompassing over 2 million slices, paired with their respective radiological reports. Expanding upon the foundational work of our dataset, we craft a retrieval strategy, MedFinder. This approach employs a dual-stream network architecture, harnessing the potential of large language models to advance the field of medical image retrieval beyond existing text-image retrieval solutions. It marks our preliminary step towards developing a system capable of facilitating text-to-image, image-to-text, and keyword-based retrieval tasks. Our project is available at \url{https://huggingface.co/datasets/cyd0806/BIMCV-R}.

Ziliang Gan, Yu Lu, Dong Zhang et al.

In recent years, multimodal benchmarks for general domains have guided the rapid development of multimodal models on general tasks. However, the financial field has its peculiarities. It features unique graphical images (e.g., candlestick charts, technical indicator charts) and possesses a wealth of specialized financial knowledge (e.g., futures, turnover rate). Therefore, benchmarks from general fields often fail to measure the performance of multimodal models in the financial domain, and thus cannot effectively guide the rapid development of large financial models. To promote the development of large financial multimodal models, we propose MME-Finance, an bilingual open-ended and practical usage-oriented Visual Question Answering (VQA) benchmark. The characteristics of our benchmark are finance and expertise, which include constructing charts that reflect the actual usage needs of users (e.g., computer screenshots and mobile photography), creating questions according to the preferences in financial domain inquiries, and annotating questions by experts with 10+ years of experience in the financial industry. Additionally, we have developed a custom-designed financial evaluation system in which visual information is first introduced in the multi-modal evaluation process. Extensive experimental evaluations of 19 mainstream MLLMs are conducted to test their perception, reasoning, and cognition capabilities. The results indicate that models performing well on general benchmarks cannot do well on MME-Finance; for instance, the top-performing open-source and closed-source models obtain 65.69 (Qwen2VL-72B) and 63.18 (GPT-4o), respectively. Their performance is particularly poor in categories most relevant to finance, such as candlestick charts and technical indicator charts. In addition, we propose a Chinese version, which helps compare performance of MLLMs under a Chinese context.

Zhongwei Wan, Che Liu, Xin Wang et al.

Electrocardiogram (ECG) is the primary non-invasive diagnostic tool for monitoring cardiac conditions and is crucial in assisting clinicians. Recent studies have concentrated on classifying cardiac conditions using ECG data but have overlooked ECG report generation, which is time-consuming and requires clinical expertise. To automate ECG report generation and ensure its versatility, we propose the Multimodal ECG Instruction Tuning (MEIT) framework, the first attempt to tackle ECG report generation with LLMs and multimodal instructions. To facilitate future research, we establish a benchmark to evaluate MEIT with various LLMs backbones across two large-scale ECG datasets. Our approach uniquely aligns the representations of the ECG signal and the report, and we conduct extensive experiments to benchmark MEIT with nine open-source LLMs using more than 800,000 ECG reports. MEIT's results underscore the superior performance of instruction-tuned LLMs, showcasing their proficiency in quality report generation, zero-shot capabilities, resilience to signal perturbation, and alignment with human expert evaluation. These findings emphasize the efficacy of MEIT and its potential for real-world clinical application.

Zhongwei Wan, Hui Shen, Xin Wang et al.

Long-context Multimodal Large Language Models (MLLMs) that incorporate long text-image and text-video modalities, demand substantial resources as their multimodal Key-Value (KV) caches grow with increasing input lengths, challenging inference efficiency. Existing methods for KV cache compression, in both text-only and multimodal LLMs, have neglected attention density variations across layers, thus often adopting uniform or progressive reduction strategies for layer-wise cache allocation. In this work, we propose MEDA, a dynamic layer-wise KV cache allocation method for efficient multimodal long-context inference. As its core, MEDA utilizes cross-modal attention entropy to determine the KV cache size at each MLLMs layer. Given the dynamically allocated KV cache size at each layer, MEDA also employs a KV pair selection scheme to identify which KV pairs to select and a KV pair merging strategy that merges the selected and non-selected ones to preserve information from the entire context. MEDA achieves up to 72% KV cache memory reduction and 2.82 times faster decoding speed, while maintaining or enhancing performance on various multimodal tasks in long-context settings, including multi-images and long-video scenarios. Our code is released at https://github.com/AIoT-MLSys-Lab/MEDA.

Minghe Shen, Zhuo Zhi, Chonghan Liu et al.

While Vision-Language Models (VLMs) post-trained with Reinforcement Learning (RL) show impressive general reasoning, their evaluation is often confined to language-dominant tasks (e.g., math). This raises a critical question: can RL post-training truly extend the inherent capability boundary of a base VLM, particularly for visual-centric spatial tasks where it initially fails? To investigate this, we introduce Ariadne, a framework utilizing synthetic mazes for multi-step spatial reasoning where task difficulty (e.g., path length, turns) is precisely controlled. We leverage this controllable environment to train VLMs using Reinforcement Learning with Verified Rewards (RLVR) in a difficulty-aware curriculum. Surprisingly, post-RLVR training, the VLM achieves over 50% accuracy on a problem set where the base model scored 0%, demonstrating that our approach expands the model's initial capability boundary. To assess real-world viability, we evaluate out-of-distribution (OOD) generalization on practical benchmarks. Despite training only on synthetic maze samples, Ariadne achieves significant zero-shot improvements, averaging 16% on MapBench (e.g., museum navigation) and 24% on ReasonMap (subway transfer tasks). These results confirm that our method not only broadens the model's fundamental limits but also enhances its generalization to real-world spatial reasoning. We acknowledge our study is limited to the post-training phase, given the opaqueness of pre-training data, and hope our research motivates further work on specialized, capability-extending alignment.

Xiaoyu Chen, Changde Du, Che Liu et al.

Decoding language information from brain signals represents a vital research area within brain-computer interfaces, particularly in the context of deciphering the semantic information from the fMRI signal. However, many existing efforts concentrate on decoding small vocabulary sets, leaving space for the exploration of open vocabulary continuous text decoding. In this paper, we introduce a novel method, the \textbf{Brain Prompt GPT (BP-GPT)}. By using the brain representation that is extracted from the fMRI as a prompt, our method can utilize GPT-2 to decode fMRI signals into stimulus text. Further, we introduce a text-to-text baseline and align the fMRI prompt to the text prompt. By introducing the text-to-text baseline, our BP-GPT can extract a more robust brain prompt and promote the decoding of pre-trained LLM. We evaluate our BP-GPT on the open-source auditory semantic decoding dataset and achieve a significant improvement up to $4.61\%$ on METEOR and $2.43\%$ on BERTScore across all the subjects compared to the state-of-the-art method. The experimental results demonstrate that using brain representation as a prompt to further drive LLM for auditory neural decoding is feasible and effective.

Jiazhen Pan, Bailiang Jian, Paul Hager et al.

Ensuring the safety and reliability of large language models (LLMs) in clinical practice is critical to prevent patient harm and promote trustworthy healthcare applications of AI. However, LLMs are advancing so rapidly that static safety benchmarks often become obsolete upon publication, yielding only an incomplete and sometimes misleading picture of model trustworthiness. We demonstrate that a Dynamic, Automatic, and Systematic (DAS) red-teaming framework that continuously stress-tests LLMs can reveal significant weaknesses of current LLMs across four safety-critical domains: robustness, privacy, bias/fairness, and hallucination. A suite of adversarial agents is applied to autonomously mutate test cases, identify/evolve unsafe-triggering strategies, and evaluate responses, uncovering vulnerabilities in real time without human intervention. Applying DAS to 15 proprietary and open-source LLMs revealed a stark contrast between static benchmark performance and vulnerability under adversarial pressure. Despite a median MedQA accuracy exceeding 80\%, 94\% of previously correct answers failed our dynamic robustness tests. We observed similarly high failure rates across other domains: privacy leaks were elicited in 86\% of scenarios, cognitive-bias priming altered clinical recommendations in 81\% of fairness tests, and we identified hallucination rates exceeding 66\% in widely used models. Such profound residual risks are incompatible with routine clinical practice. By converting red-teaming from a static checklist into a dynamic stress-test audit, DAS red-teaming offers the surveillance that hospitals/regulators/technology vendors require as LLMs become embedded in patient chatbots, decision-support dashboards, and broader healthcare workflows. Our framework delivers an evolvable, scalable, and reliable safeguard for the next generation of medical AI.

Weiying Lin, Che Liu, Xin Zhang et al.

Implementing precise detection of oil leaks in peak load equipment through image analysis can significantly enhance inspection quality and ensure the system's safety and reliability. However, challenges such as varying shapes of oil-stained regions, background noise, and fluctuating lighting conditions complicate the detection process. To address this, the integration of logical rule-based discrimination into image recognition has been proposed. This approach involves recognizing the spatial relationships among objects to semantically segment images of oil spills using a Mask RCNN network. The process begins with histogram equalization to enhance the original image, followed by the use of Mask RCNN to identify the preliminary positions and outlines of oil tanks, the ground, and areas of potential oil contamination. Subsequent to this identification, the spatial relationships between these objects are analyzed. Logical rules are then applied to ascertain whether the suspected areas are indeed oil spills. This method's effectiveness has been confirmed by testing on images captured from peak power equipment in the field. The results indicate that this approach can adeptly tackle the challenges in identifying oil-contaminated areas, showing a substantial improvement in accuracy compared to existing methods.

Canyu Chen, Jian Yu, Shan Chen et al. · harvard

Large Language Models (LLMs) hold great promise to revolutionize current clinical systems for their superior capacities on medical text processing tasks and medical licensing exams. Meanwhile, traditional ML models such as SVM and XGBoost have still been mainly adopted in clinical prediction tasks. An emerging question is Can LLMs beat traditional ML models in clinical prediction? Thus, we build a new benchmark ClinicalBench to comprehensively study the clinical predictive modeling capacities of both general-purpose and medical LLMs, and compare them with traditional ML models. ClinicalBench embraces three common clinical prediction tasks, two databases, 14 general-purpose LLMs, 8 medical LLMs, and 11 traditional ML models. Through extensive empirical investigation, we discover that both general-purpose and medical LLMs, even with different model scales, diverse prompting or fine-tuning strategies, still cannot beat traditional ML models in clinical prediction yet, shedding light on their potential deficiency in clinical reasoning and decision-making. We call for caution when practitioners adopt LLMs in clinical applications. ClinicalBench can be utilized to bridge the gap between LLMs' development for healthcare and real-world clinical practice.

Hongjin Su, Shuyang Jiang, Yuhang Lai et al.

Recently the retrieval-augmented generation (RAG) has been successfully applied in code generation. However, existing pipelines for retrieval-augmented code generation (RACG) employ static knowledge bases with a single source, limiting the adaptation capabilities of Large Language Models (LLMs) to domains they have insufficient knowledge of. In this work, we develop a novel pipeline, EVOR, that employs the synchronous evolution of both queries and diverse knowledge bases. On two realistic settings where the external knowledge is required to solve code generation tasks, we compile four new datasets associated with frequently updated libraries and long-tail programming languages, named EVOR-BENCH. Extensive experiments demonstrate that EVOR achieves two to four times of execution accuracy compared to other methods such as Reflexion (Shinn et al., 2024), DocPrompting (Zhou et al., 2023), etc. We demonstrate that EVOR is flexible and can be easily combined with them to achieve further improvement. Further analysis reveals that EVOR benefits from the synchronous evolution of queries and documents and the diverse information sources in the knowledge base. We hope that our studies will inspire more insights into the design of advanced RACG pipelines in future research. Our model, code, and data are available at https://arks-codegen.github.io.

Che Liu, Zhongwei Wan, Haozhe Wang et al.

Medical Vision-Language Pre-training (MedVLP) has made significant progress in enabling zero-shot tasks for medical image understanding. However, training MedVLP models typically requires large-scale datasets with paired, high-quality image-text data, which are scarce in the medical domain. Recent advancements in Large Language Models (LLMs) and diffusion models have made it possible to generate large-scale synthetic image-text pairs. This raises the question: "Can MedVLP succeed using purely synthetic data?" To address this, we use off-the-shelf generative models to create synthetic radiology reports and paired Chest X-ray (CXR) images, and propose an automated pipeline to build a diverse, high-quality synthetic dataset, enabling a rigorous study that isolates model and training settings, focusing entirely from the data perspective. Our results show that MedVLP models trained exclusively on synthetic data outperform those trained on real data by 3.8% in averaged AUC on zero-shot classification. Moreover, using a combination of synthetic and real data leads to a further improvement of 9.07%. Additionally, MedVLP models trained on synthetic or mixed data consistently outperform those trained on real data in zero-shot grounding, as well as in fine-tuned classification and segmentation tasks. Our analysis suggests MedVLP trained on well-designed synthetic data can outperform models trained on real datasets, which may be limited by low-quality samples and long-tailed distributions.

Jiao Ou, Jiayu Wu, Che Liu et al.

Aligning large language models (LLMs) with human expectations requires high-quality instructional dialogues, which usually require instructions that are diverse and in-depth. Existing methods leverage two LLMs to interact for automatic collection: one simulating a user to pose instructions, and the other acting as a system agent to respond. However, these user simulators struggle to model the rules behind how dialogues can pose different instructions without explicit guidance, resulting in general instructions. In this paper, we propose to explicitly capture the complex rules to help the user simulator pose diverse and in-depth instruction. Specifically, we first induce high-level instruction strategies from various real instruction dialogues serving as rules. Afterward, different possible strategies are applied to the newly given dialogue scenario deductively to pose various instructions. Experimental results show that our method can generate diverse and in-depth instructions. The constructed multi-turn instructional dialogues can outperform competitive baselines on the downstream chat model.

Jiuming Qin, Che Liu, Sibo Cheng et al.

Modern healthcare often utilises radiographic images alongside textual reports for diagnostics, encouraging the use of Vision-Language Self-Supervised Learning (VL-SSL) with large pre-trained models to learn versatile medical vision representations. However, most existing VL-SSL frameworks are trained end-to-end, which is computation-heavy and can lose vital prior information embedded in pre-trained encoders. To address both issues, we introduce the backbone-agnostic Adaptor framework, which preserves medical knowledge in pre-trained image and text encoders by keeping them frozen, and employs a lightweight Adaptor module for cross-modal learning. Experiments on medical image classification and segmentation tasks across three datasets reveal that our framework delivers competitive performance while cutting trainable parameters by over 90% compared to current pre-training approaches. Notably, when fine-tuned with just 1% of data, Adaptor outperforms several Transformer-based methods trained on full datasets in medical image segmentation.

Yihong Tang, Jiao Ou, Che Liu et al.

The advent of Large Language Models (LLMs) has propelled dialogue generation into new realms, particularly in the field of role-playing systems (RPSs). While enhanced with ordinary role-relevant training dialogues, existing LLM-based RPSs still struggle to align with roles when handling intricate and trapped queries in boundary scenarios. In this paper, we design the Modular ORchestrated Trap-setting Interaction SystEm (MORTISE) to benchmark and improve the role-playing LLMs' performance. MORTISE can produce highly role-relevant aggressive queries through the collaborative effort of multiple LLM-based modules, and formulate corresponding responses to create an adversarial training dataset via a consistent response generator. We select 190 Chinese and English roles to construct aggressive queries to benchmark existing role-playing LLMs. Through comprehensive evaluation, we find that existing models exhibit a general deficiency in role alignment capabilities. We further select 180 of the roles to collect an adversarial training dataset (named RoleAD) and retain the other 10 roles for testing. Experiments on models improved by RoleAD indicate that our adversarial dataset ameliorates this deficiency, with the improvements demonstrating a degree of generalizability in ordinary scenarios.

Jiawen Wang, Yinda Chen, Xiaoyu Liu et al.

Recent works have correlated Masked Image Modeling (MIM) with consistency regularization in Unsupervised Domain Adaptation (UDA). However, they merely treat masking as a special form of deformation on the input images and neglect the theoretical analysis, which leads to a superficial understanding of masked reconstruction and insufficient exploitation of its potential in enhancing feature extraction and representation learning. In this paper, we reframe masked reconstruction as a sparse signal reconstruction problem and theoretically prove that the dual form of complementary masks possesses superior capabilities in extracting domain-agnostic image features. Based on this compelling insight, we propose MaskTwins, a simple yet effective UDA framework that integrates masked reconstruction directly into the main training pipeline. MaskTwins uncovers intrinsic structural patterns that persist across disparate domains by enforcing consistency between predictions of images masked in complementary ways, enabling domain generalization in an end-to-end manner. Extensive experiments verify the superiority of MaskTwins over baseline methods in natural and biological image segmentation. These results demonstrate the significant advantages of MaskTwins in extracting domain-invariant features without the need for separate pre-training, offering a new paradigm for domain-adaptive segmentation.

Haitao Li, Che Liu, Zhengyao Ding et al.

Electrocardiograms (ECGs) are essential for diagnosing cardiovascular diseases. However, existing ECG-Report contrastive learning methods focus on whole-ECG and report alignment, missing the link between local ECG features and individual report tags. In this paper, we propose FG-CLEP (Fine-Grained Contrastive Language ECG Pre-training), which achieves fine-grained alignment between specific ECG segments and each tag in the report via tag-specific ECG representations. Furthermore, we found that nearly 55\% of ECG reports in the MIMIC-ECG training dataset lack detailed waveform features, which hinders fine-grained alignment. To address this, we introduce a coarse-to-fine training process that leverages large language models (LLMs) to recover these missing waveform features and validate the LLM outputs using a coarse model. Additionally, fine-grained alignment at the tag level, rather than at the report level, exacerbates the false negative problem, as different reports may share common tags. To mitigate this, we introduce a semantic similarity matrix to guide the model in identifying and correcting false negatives. Experiments on six datasets demonstrate that FG-CLEP significantly improves fine-grained alignment, outperforming state-of-the-art methods in both zero-shot prediction and linear probing. Meanwhile, the fine-grained reports we generate also enhance the performance of other methods.

Zhongwei Wan, Ziang Wu, Che Liu et al.

Long-context Multimodal Large Language Models (MLLMs) demand substantial computational resources for inference as the growth of their multimodal Key-Value (KV) cache, in response to increasing input lengths, challenges memory and time efficiency. Unlike single-modality LLMs that manage only textual contexts, the KV cache of long-context MLLMs includes representations from multiple images with temporal and spatial relationships and related textual contexts. The predominance of image tokens means traditional optimizations for LLMs' KV caches are unsuitable for multimodal long-context settings, and no prior works have addressed this challenge. In this work, we introduce LOOK-M, a pioneering, fine-tuning-free approach that efficiently reduces the multimodal KV cache size while maintaining performance comparable to a full cache. We observe that during prompt prefill, the model prioritizes more textual attention over image features, and based on the multimodal interaction observation, a new proposed text-prior method is explored to compress the KV cache. Furthermore, to mitigate the degradation of image contextual information, we propose several compensatory strategies using KV pairs merging. LOOK-M demonstrates that with a significant reduction in KV Cache memory usage, such as reducing it by 80% in some cases, it not only achieves up to 1.5x faster decoding but also maintains or even enhances performance across a variety of long context multimodal tasks.

Zhongwei Wan, Che Liu, Mi Zhang et al.

The scarcity of data presents a critical obstacle to the efficacy of medical visionlanguage pre-training (VLP). A potential solution lies in the combination of datasets from various language communities. Nevertheless, the main challenge stems from the complexity of integrating diverse syntax and semantics, language-specific medical terminology, and culture-specific implicit knowledge. Therefore, one crucial aspect to consider is the presence of community bias caused by different languages. This paper presents a novel framework named Unifying Cross-Lingual Medical Vision-Language Pre-Training (Med-UniC), designed to integrate multimodal medical data from the two most prevalent languages, English and Spanish. Specifically, we propose Cross-lingual Text Alignment Regularization (CTR) to explicitly unify cross-lingual semantic representations of medical reports originating from diverse language communities. CTR is optimized through latent language disentanglement, rendering our optimization objective to not depend on negative samples, thereby significantly mitigating the bias from determining positive-negative sample pairs within analogous medical reports. Furthermore, it ensures that the cross-lingual representation is not biased toward any specific language community. Med-UniC reaches superior performance across 5 medical image tasks and 10 datasets encompassing over 30 diseases, offering a versatile framework for unifying multi-modal medical data within diverse linguistic communities. The experimental outcomes highlight the presence of community bias in cross-lingual VLP. Reducing this bias enhances the performance not only in vision-language tasks but also in uni-modal visual tasks.

Che Liu, Rui Wang, Jinghua Liu et al.

Learning sentence embeddings from dialogues has drawn increasing attention due to its low annotation cost and high domain adaptability. Conventional approaches employ the siamese-network for this task, which obtains the sentence embeddings through modeling the context-response semantic relevance by applying a feed-forward network on top of the sentence encoders. However, as the semantic textual similarity is commonly measured through the element-wise distance metrics (e.g. cosine and L2 distance), such architecture yields a large gap between training and evaluating. In this paper, we propose DialogueCSE, a dialogue-based contrastive learning approach to tackle this issue. DialogueCSE first introduces a novel matching-guided embedding (MGE) mechanism, which generates a context-aware embedding for each candidate response embedding (i.e. the context-free embedding) according to the guidance of the multi-turn context-response matching matrices. Then it pairs each context-aware embedding with its corresponding context-free embedding and finally minimizes the contrastive loss across all pairs. We evaluate our model on three multi-turn dialogue datasets: the Microsoft Dialogue Corpus, the Jing Dong Dialogue Corpus, and the E-commerce Dialogue Corpus. Evaluation results show that our approach significantly outperforms the baselines across all three datasets in terms of MAP and Spearman's correlation measures, demonstrating its effectiveness. Further quantitative experiments show that our approach achieves better performance when leveraging more dialogue context and remains robust when less training data is provided.

Chao Xiong, Che Liu, Zijun Xu et al.

Recently, open domain multi-turn chatbots have attracted much interest from lots of researchers in both academia and industry. The dominant retrieval-based methods use context-response matching mechanisms for multi-turn response selection. Specifically, the state-of-the-art methods perform the context-response matching by word or segment similarity. However, these models lack a full exploitation of the sentence-level semantic information, and make simple mistakes that humans can easily avoid. In this work, we propose a matching network, called sequential sentence matching network (S2M), to use the sentence-level semantic information to address the problem. Firstly and most importantly, we find that by using the sentence-level semantic information, the network successfully addresses the problem and gets a significant improvement on matching, resulting in a state-of-the-art performance. Furthermore, we integrate the sentence matching we introduced here and the usual word similarity matching reported in the current literature, to match at different semantic levels. Experiments on three public data sets show that such integration further improves the model performance.

Lianlin Li, Long Gang Wang, Fernando L. Teixeira et al.

Nonlinear electromagnetic (EM) inverse scattering is a quantitative and super-resolution imaging technique, in which more realistic interactions between the internal structure of scene and EM wavefield are taken into account in the imaging procedure, in contrast to conventional tomography. However, it poses important challenges arising from its intrinsic strong nonlinearity, ill-posedness, and expensive computation costs. To tackle these difficulties, we, for the first time to our best knowledge, exploit a connection between the deep neural network (DNN) architecture and the iterative method of nonlinear EM inverse scattering. This enables the development of a novel DNN-based methodology for nonlinear EM inverse problems (termed here DeepNIS). The proposed DeepNIS consists of a cascade of multi-layer complexvalued residual convolutional neural network (CNN) modules. We numerically and experimentally demonstrate that the DeepNIS outperforms remarkably conventional nonlinear inverse scattering methods in terms of both the image quality and computational time. We show that DeepNIS can learn a general model approximating the underlying EM inverse scattering system. It is expected that the DeepNIS will serve as powerful tool in treating highly nonlinear EM inverse scattering problems over different frequency bands, involving large-scale and high-contrast objects, which are extremely hard and impractical to solve using conventional inverse scattering methods.