Abdul Joseph Fofanah

Karim Lekadir, Aasa Feragen, Abdul Joseph Fofanah et al. · eth-zurich

Despite major advances in artificial intelligence (AI) for medicine and healthcare, the deployment and adoption of AI technologies remain limited in real-world clinical practice. In recent years, concerns have been raised about the technical, clinical, ethical and legal risks associated with medical AI. To increase real world adoption, it is essential that medical AI tools are trusted and accepted by patients, clinicians, health organisations and authorities. This work describes the FUTURE-AI guideline as the first international consensus framework for guiding the development and deployment of trustworthy AI tools in healthcare. The FUTURE-AI consortium was founded in 2021 and currently comprises 118 inter-disciplinary experts from 51 countries representing all continents, including AI scientists, clinicians, ethicists, and social scientists. Over a two-year period, the consortium defined guiding principles and best practices for trustworthy AI through an iterative process comprising an in-depth literature review, a modified Delphi survey, and online consensus meetings. The FUTURE-AI framework was established based on 6 guiding principles for trustworthy AI in healthcare, i.e. Fairness, Universality, Traceability, Usability, Robustness and Explainability. Through consensus, a set of 28 best practices were defined, addressing technical, clinical, legal and socio-ethical dimensions. The recommendations cover the entire lifecycle of medical AI, from design, development and validation to regulation, deployment, and monitoring. FUTURE-AI is a risk-informed, assumption-free guideline which provides a structured approach for constructing medical AI tools that will be trusted, deployed and adopted in real-world practice. Researchers are encouraged to take the recommendations into account in proof-of-concept stages to facilitate future translation towards clinical practice of medical AI.

Abdul Joseph Fofanah, Lian Wen, David Chen

Accurate traffic flow prediction remains a fundamental challenge in intelligent transportation systems, particularly in cross-domain, data-scarce scenarios where limited historical data hinders model training and generalisation. The complex spatio-temporal dependencies and nonlinear dynamics of urban mobility networks further complicate few-shot learning across different cities. This paper proposes MCPST, a novel Multi-phase Consensus Spatio-Temporal framework for few-shot traffic forecasting that reconceptualises traffic prediction as a multi-phase consensus learning problem. Our framework introduces three core innovations: (1) a multi-phase engine that models traffic dynamics through diffusion, synchronisation, and spectral embeddings for comprehensive dynamic characterisation; (2) an adaptive consensus mechanism that dynamically fuses phase-specific predictions while enforcing consistency; and (3) a structured meta-learning strategy for rapid adaptation to new cities with minimal data. We establish extensive theoretical guarantees, including representation theorems with bounded approximation errors and generalisation bounds for few-shot adaptation. Through experiments on four real-world datasets, MCPST outperforms fourteen state-of-the-art methods in spatio-temporal graph learning methods, dynamic graph transfer learning methods, prompt-based spatio-temporal prediction methods and cross-domain few-shot settings, improving prediction accuracy while reducing required training data and providing interpretable insights. The implementation code is available at https://github.com/afofanah/MCPST.

Abdul Joseph Fofanah, Lian Wen, David Chen

Graph neural networks (GNNs) often struggle in class-imbalanced settings, where minority classes are under-represented and predictions are biased toward majorities. We propose \textbf{PIMPC-GNN}, a physics-informed multi-phase consensus framework for imbalanced node classification. Our method integrates three complementary dynamics: (i) thermodynamic diffusion, which spreads minority labels to capture long-range dependencies, (ii) Kuramoto synchronisation, which aligns minority nodes through oscillatory consensus, and (iii) spectral embedding, which separates classes via structural regularisation. These perspectives are combined through class-adaptive ensemble weighting and trained with an imbalance-aware loss that couples balanced cross-entropy with physics-based constraints. Across five benchmark datasets and imbalance ratios from 5-100, PIMPC-GNN outperforms 16 state-of-the-art baselines, achieving notable gains in minority-class recall (up to +12.7\%) and balanced accuracy (up to +8.3\%). Beyond empirical improvements, the framework also provides interpretable insights into consensus dynamics in graph learning. The code is available at \texttt{https://github.com/afofanah/PIMPC-GNN}.

Abdul Joseph Fofanah, Lian Wen, David Chen et al.

Imbalanced node classification in graph neural networks (GNNs) happens when some labels are much more common than others, which causes the model to learn unfairly and perform badly on the less common classes. To solve this problem, we propose a Curriculum-Guided Feature Learning and Three-Stage Attention Network (CL3AN-GNN), a learning network that uses a three-step attention system (Engage, Enact, Embed) similar to how humans learn. The model begins by engaging with structurally simpler features, defined as (1) local neighbourhood patterns (1-hop), (2) low-degree node attributes, and (3) class-separable node pairs identified via initial graph convolutional networks and graph attention networks (GCN and GAT) embeddings. This foundation enables stable early learning despite label skew. The Enact stage then addresses complicated aspects: (1) connections that require multiple steps, (2) edges that connect different types of nodes, and (3) nodes at the edges of minority classes by using adjustable attention weights. Finally, Embed consolidates these features via iterative message passing and curriculum-aligned loss weighting. We evaluate CL3AN-GNN on eight Open Graph Benchmark datasets spanning social, biological, and citation networks. Experiments show consistent improvements across all datasets in accuracy, F1-score, and AUC over recent state-of-the-art methods. The model's step-by-step method works well with different types of graph datasets, showing quicker results than training everything at once, better performance on new, imbalanced graphs, and clear explanations of each step using gradient stability and attention correlation learning curves. This work provides both a theoretically grounded framework for curriculum learning in GNNs and practical evidence of its effectiveness against imbalances, validated through metrics, convergence speeds, and generalisation tests.

Abdul Joseph Fofanah, Lian Wen, David Chen et al.

Traffic prediction in data-scarce, cross-city settings is challenging due to complex nonlinear dynamics and domain shifts. Existing methods often fail to capture traffic's inherent chaotic nature for effective few-shot learning. We propose CAST-CKT, a novel Chaos-Aware Spatio-Temporal and Cross-City Knowledge Transfer framework. It employs an efficient chaotic analyser to quantify traffic predictability regimes, driving several key innovations: chaos-aware attention for regime-adaptive temporal modelling; adaptive topology learning for dynamic spatial dependencies; and chaotic consistency-based cross-city alignment for knowledge transfer. The framework also provides horizon-specific predictions with uncertainty quantification. Theoretical analysis shows improved generalisation bounds. Extensive experiments on four benchmarks in cross-city few-shot settings show CAST-CKT outperforms state-of-the-art methods by significant margins in MAE and RMSE, while offering interpretable regime analysis. Code is available at https://github.com/afofanah/CAST-CKT.

Abdul Joseph Fofanah, Lian Wen, David Chen et al.

Anomaly detection in dynamic networks is critical for applications from cybersecurity to industrial monitoring, yet existing methods face challenges in energy efficiency, temporal precision, and adaptability. This paper introduces ASTDP-GAD, a novel Adaptive Spiking Temporal Dynamics Plasticity framework for Graph Anomaly Detection that integrates spiking graph neural networks with STDP learning for energy-efficient neuromorphic detection in dynamic networks. Our framework unifies spiking neural computation, STDP learning, and graph-based anomaly detection through the following key innovations: temporal spike graph encoding with adaptive Leaky Integrate-and-Fire (LIF) dynamics; LIF-based graph attention with lateral inhibition; event-driven hypergraph memory with STDP-inspired prototype updates; spike rate contrast pooling based on spiking irregularity; adaptive STDP layers capturing causal temporal relationships; and multi-scale temporal convolution with multi-factor anomaly fusion. Theoretical analysis provides rigorous guarantees: spike encoding preserves input information with resolution scaling linearly in simulation steps and hidden dimension; LIFGAT approximates any continuous attention function; hypergraph memory converges to optimal prototypes; contrast pooling achieves provable anomaly selection bounds; STDP learning converges stably; and multi-factor fusion produces calibrated scores with up to $5\times$ variance reduction. Extensive experiments on nine datasets on both dynamic and static graphs demonstrate superior anomaly detection accuracy while maintaining biological plausibility and energy efficiency for neuromorphic deployment.

Zhongyi Zhang, Julie A. Hides, Enrico De Martino et al.

Purpose: To develop and validate No-New SAM2 (nnsam2) for few-shot segmentation of lumbar paraspinal muscles using only a single annotated slice per dataset, and to assess its statistical comparability with expert measurements across multi-sequence MRI and multi-protocol CT. Methods: We retrospectively analyzed 1,219 scans (19,439 slices) from 762 participants across six datasets. Six slices (one per dataset) served as labeled examples, while the remaining 19,433 slices were used for testing. In this minimal-supervision setting, nnsam2 used single-slice SAM2 prompts to generate pseudo-labels, which were pooled across datasets and refined through three sequential, independent nnU-Net models. Segmentation performance was evaluated using the Dice similarity coefficient (DSC), and automated measurements-including muscle volume, fat ratio, and CT attenuation-were assessed with two one-sided tests (TOST) and intraclass correlation coefficients (ICC). Results: nnsam2 outperformed vanilla SAM2, its medical variants, TotalSegmentator, and the leading few-shot method, achieving DSCs of 0.94-0.96 on MR images and 0.92-0.93 on CT. Automated and expert measurements were statistically equivalent for muscle volume (MRI/CT), CT attenuation, and Dixon fat ratio (TOST, P < 0.05), with consistently high ICCs (0.86-1.00). Conclusion: We developed nnsam2, a state-of-the-art few-shot framework for multi-modality LPM segmentation, producing muscle volume (MRI/CT), attenuation (CT), and fat ratio (Dixon MRI) measurements that were statistically comparable to expert references. Validated across multimodal, multicenter, and multinational cohorts, and released with open code and data, nnsam2 demonstrated high annotation efficiency, robust generalizability, and reproducibility.