Ross W. Filice

Adrit Rao, Malte Jensen, Andrea T. Fisher et al.

Artificial intelligence allows automatic extraction of imaging biomarkers from already-acquired radiologic images. This paradigm of opportunistic imaging adds value to medical imaging without additional imaging costs or patient radiation exposure. However, many open-source image analysis solutions lack rigorous validation while commercial solutions lack transparency, leading to unexpected failures when deployed. Here, we report development and validation for two of the first fully open-sourced, FDA-510(k)-cleared deep learning pipelines to mitigate both challenges: Abdominal Aortic Quantification (AAQ) and Bone Mineral Density (BMD) estimation are both offered within the Comp2Comp package for opportunistic analysis of computed tomography scans. AAQ segments the abdominal aorta to assess aneurysm size; BMD segments vertebral bodies to estimate trabecular bone density and osteoporosis risk. AAQ-derived maximal aortic diameters were compared against radiologist ground-truth measurements on 258 patient scans enriched for abdominal aortic aneurysms from four external institutions. BMD binary classifications (low vs. normal bone density) were compared against concurrent DXA scan ground truths obtained on 371 patient scans from four external institutions. AAQ had an overall mean absolute error of 1.57 mm (95% CI 1.38-1.80 mm). BMD had a sensitivity of 81.0% (95% CI 74.0-86.8%) and specificity of 78.4% (95% CI 72.3-83.7%). Comp2Comp AAQ and BMD demonstrated sufficient accuracy for clinical use. Open-sourcing these algorithms improves transparency of typically opaque FDA clearance processes, allows hospitals to test the algorithms before cumbersome clinical pilots, and provides researchers with best-in-class methods.

Sajad Sotudeh, Nazli Goharian, Ross W. Filice

Sequence-to-sequence (seq2seq) network is a well-established model for text summarization task. It can learn to produce readable content; however, it falls short in effectively identifying key regions of the source. In this paper, we approach the content selection problem for clinical abstractive summarization by augmenting salient ontological terms into the summarizer. Our experiments on two publicly available clinical data sets (107,372 reports of MIMIC-CXR, and 3,366 reports of OpenI) show that our model statistically significantly boosts state-of-the-art results in terms of Rouge metrics (with improvements: 2.9% RG-1, 2.5% RG-2, 1.9% RG-L), in the healthcare domain where any range of improvement impacts patients' welfare.

Sean MacAvaney, Sajad Sotudeh, Arman Cohan et al.

Automatically generating accurate summaries from clinical reports could save a clinician's time, improve summary coverage, and reduce errors. We propose a sequence-to-sequence abstractive summarization model augmented with domain-specific ontological information to enhance content selection and summary generation. We apply our method to a dataset of radiology reports and show that it significantly outperforms the current state-of-the-art on this task in terms of rouge scores. Extensive human evaluation conducted by a radiologist further indicates that this approach yields summaries that are less likely to omit important details, without sacrificing readability or accuracy.