Benchmarking LLMs for Pairwise Causal Discovery in Biomedical and Multi-Domain ContextsSydney Anuyah, Sneha Shajee-Mohan, Ankit-Singh Chauhan et al.
The safe deployment of large language models (LLMs) in high-stakes fields like biomedicine, requires them to be able to reason about cause and effect. We investigate this ability by testing 13 open-source LLMs on a fundamental task: pairwise causal discovery (PCD) from text. Our benchmark, using 12 diverse datasets, evaluates two core skills: 1) \textbf{Causal Detection} (identifying if a text contains a causal link) and 2) \textbf{Causal Extraction} (pulling out the exact cause and effect phrases). We tested various prompting methods, from simple instructions (zero-shot) to more complex strategies like Chain-of-Thought (CoT) and Few-shot In-Context Learning (FICL). The results show major deficiencies in current models. The best model for detection, DeepSeek-R1-Distill-Llama-70B, only achieved a mean score of 49.57\% ($C_{detect}$), while the best for extraction, Qwen2.5-Coder-32B-Instruct, reached just 47.12\% ($C_{extract}$). Models performed best on simple, explicit, single-sentence relations. However, performance plummeted for more difficult (and realistic) cases, such as implicit relationships, links spanning multiple sentences, and texts containing multiple causal pairs. We provide a unified evaluation framework, built on a dataset validated with high inter-annotator agreement ($κ\ge 0.758$), and make all our data, code, and prompts publicly available to spur further research. \href{https://github.com/sydneyanuyah/CausalDiscovery}{Code available here: https://github.com/sydneyanuyah/CausalDiscovery}
Domain-Specific Knowledge Graphs in RAG-Enhanced Healthcare LLMsSydney Anuyah, Mehedi Mahmud Kaushik, Hao Dai et al.
Large Language Models (LLMs) generate fluent answers but can struggle with trustworthy, domain-specific reasoning. We evaluate whether domain knowledge graphs (KGs) improve Retrieval-Augmented Generation (RAG) for healthcare by constructing three PubMed-derived graphs: $\mathbb{G}_1$ (T2DM), $\mathbb{G}_2$ (Alzheimer's disease), and $\mathbb{G}_3$ (AD+T2DM). We design two probes: Probe 1 targets merged AD T2DM knowledge, while Probe 2 targets the intersection of $\mathbb{G}_1$ and $\mathbb{G}_2$. Seven instruction-tuned LLMs are tested across retrieval sources {No-RAG, $\mathbb{G}_1$, $\mathbb{G}_2$, $\mathbb{G}_1$ + $\mathbb{G}_2$, $\mathbb{G}_3$, $\mathbb{G}_1$+$\mathbb{G}_2$ + $\mathbb{G}_3$} and three decoding temperatures. Results show that scope alignment between probe and KG is decisive: precise, scope-matched retrieval (notably $\mathbb{G}_2$) yields the most consistent gains, whereas indiscriminate graph unions often introduce distractors that reduce accuracy. Larger models frequently match or exceed KG-RAG with a No-RAG baseline on Probe 1, indicating strong parametric priors, whereas smaller/mid-sized models benefit more from well-scoped retrieval. Temperature plays a secondary role; higher values rarely help. We conclude that precision-first, scope-matched KG-RAG is preferable to breadth-first unions, and we outline practical guidelines for graph selection, model sizing, and retrieval/reranking. Code and Data available here - https://github.com/sydneyanuyah/RAGComparison