Binfeng Zou

Yifei Chen, Shenghao Zhu, Zhaojie Fang et al.

Alzheimer's Disease (AD) is a complex neurodegenerative disorder marked by memory loss, executive dysfunction, and personality changes. Early diagnosis is challenging due to subtle symptoms and varied presentations, often leading to misdiagnosis with traditional unimodal diagnostic methods due to their limited scope. This study introduces an advanced multimodal classification model that integrates clinical, cognitive, neuroimaging, and EEG data to enhance diagnostic accuracy. The model incorporates a feature tagger with a tabular data coding architecture and utilizes the TimesBlock module to capture intricate temporal patterns in Electroencephalograms (EEG) data. By employing Cross-modal Attention Aggregation module, the model effectively fuses Magnetic Resonance Imaging (MRI) spatial information with EEG temporal data, significantly improving the distinction between AD, Mild Cognitive Impairment, and Normal Cognition. Simultaneously, we have constructed the first AD classification dataset that includes three modalities: EEG, MRI, and tabular data. Our innovative approach aims to facilitate early diagnosis and intervention, potentially slowing the progression of AD. The source code and our private ADMC dataset are available at https://github.com/JustlfC03/MSTNet.

Zhaojie Fang, Shenghao Zhu, Yifei Chen et al.

Alzheimer's Disease (AD) is a progressive, irreversible neurodegenerative disorder that often originates from Mild Cognitive Impairment (MCI). This progression results in significant memory loss and severely affects patients' quality of life. Clinical trials have consistently shown that early and targeted interventions for individuals with MCI may slow or even prevent the advancement of AD. Research indicates that accurate medical classification requires diverse multimodal data, including detailed assessment scales and neuroimaging techniques like Magnetic Resonance Imaging (MRI) and Positron Emission Tomography (PET). However, simultaneously collecting the aforementioned three modalities for training presents substantial challenges. To tackle these difficulties, we propose GFE-Mamba, a multimodal classifier founded on Generative Feature Extractor. The intermediate features provided by this Extractor can compensate for the shortcomings of PET and achieve profound multimodal fusion in the classifier. The Mamba block, as the backbone of the classifier, enables it to efficiently extract information from long-sequence scale information. Pixel-level Bi-cross Attention supplements pixel-level information from MRI and PET. We provide our rationale for developing this cross-temporal progression prediction dataset and the pre-trained Extractor weights. Our experimental findings reveal that the GFE-Mamba model effectively predicts the progression from MCI to AD and surpasses several leading methods in the field. Our source code is available at https://github.com/Tinysqua/GFE-Mamba.

Yifei Chen, Binfeng Zou, Zhaoxin Guo et al.

Pulmonary embolism (PE) is a prevalent lung disease that can lead to right ventricular hypertrophy and failure in severe cases, ranking second in severity only to myocardial infarction and sudden death. Pulmonary artery CT angiography (CTPA) is a widely used diagnostic method for PE. However, PE detection presents challenges in clinical practice due to limitations in imaging technology. CTPA can produce noises similar to PE, making confirmation of its presence time-consuming and prone to overdiagnosis. Nevertheless, the traditional segmentation method of PE can not fully consider the hierarchical structure of features, local and global spatial features of PE CT images. In this paper, we propose an automatic PE segmentation method called SCUNet++ (Swin Conv UNet++). This method incorporates multiple fusion dense skip connections between the encoder and decoder, utilizing the Swin Transformer as the encoder. And fuses features of different scales in the decoder subnetwork to compensate for spatial information loss caused by the inevitable downsampling in Swin-UNet or other state-of-the-art methods, effectively solving the above problem. We provide a theoretical analysis of this method in detail and validate it on publicly available PE CT image datasets FUMPE and CAD-PE. The experimental results indicate that our proposed method achieved a Dice similarity coefficient (DSC) of 83.47% and a Hausdorff distance 95th percentile (HD95) of 3.83 on the FUMPE dataset, as well as a DSC of 83.42% and an HD95 of 5.10 on the CAD-PE dataset. These findings demonstrate that our method exhibits strong performance in PE segmentation tasks, potentially enhancing the accuracy of automatic segmentation of PE and providing a powerful diagnostic tool for clinical physicians. Our source code and new FUMPE dataset are available at https://github.com/JustlfC03/SCUNet-plusplus.

Yifei Chen, Zhu Zhu, Shenghao Zhu et al.

The incidence and mortality rates of malignant tumors, such as acute leukemia, have risen significantly. Clinically, hospitals rely on cytological examination of peripheral blood and bone marrow smears to diagnose malignant tumors, with accurate blood cell counting being crucial. Existing automated methods face challenges such as low feature expression capability, poor interpretability, and redundant feature extraction when processing high-dimensional microimage data. We propose a novel fine-grained classification model, SCKansformer, for bone marrow blood cells, which addresses these challenges and enhances classification accuracy and efficiency. The model integrates the Kansformer Encoder, SCConv Encoder, and Global-Local Attention Encoder. The Kansformer Encoder replaces the traditional MLP layer with the KAN, improving nonlinear feature representation and interpretability. The SCConv Encoder, with its Spatial and Channel Reconstruction Units, enhances feature representation and reduces redundancy. The Global-Local Attention Encoder combines Multi-head Self-Attention with a Local Part module to capture both global and local features. We validated our model using the Bone Marrow Blood Cell Fine-Grained Classification Dataset (BMCD-FGCD), comprising over 10,000 samples and nearly 40 classifications, developed with a partner hospital. Comparative experiments on our private dataset, as well as the publicly available PBC and ALL-IDB datasets, demonstrate that SCKansformer outperforms both typical and advanced microcell classification methods across all datasets. Our source code and private BMCD-FGCD dataset are available at https://github.com/JustlfC03/SCKansformer.