Better Generalizing to Unseen Concepts: An Evaluation Framework and An LLM-Based Auto-Labeled Pipeline for Biomedical Concept RecognitionShanshan Liu, Noriki Nishida, Fei Cheng et al.
Generalization to unseen concepts is a central challenge due to the scarcity of human annotations in Mention-agnostic Biomedical Concept Recognition (MA-BCR). This work makes two key contributions to systematically address this issue. First, we propose an evaluation framework built on hierarchical concept indices and novel metrics to measure generalization. Second, we explore LLM-based Auto-Labeled Data (ALD) as a scalable resource, creating a task-specific pipeline for its generation. Our research unequivocally shows that while LLM-generated ALD cannot fully substitute for manual annotations, it is a valuable resource for improving generalization, successfully providing models with the broader coverage and structural knowledge needed to approach recognizing unseen concepts. Code and datasets are available at https://github.com/bio-ie-tool/hi-ald.
Persona Jailbreaking in Large Language ModelsJivnesh Sandhan, Fei Cheng, Tushar Sandhan et al.
Large Language Models (LLMs) are increasingly deployed in domains such as education, mental health and customer support, where stable and consistent personas are critical for reliability. Yet, existing studies focus on narrative or role-playing tasks and overlook how adversarial conversational history alone can reshape induced personas. Black-box persona manipulation remains unexplored, raising concerns for robustness in realistic interactions. In response, we introduce the task of persona editing, which adversarially steers LLM traits through user-side inputs under a black-box, inference-only setting. To this end, we propose PHISH (Persona Hijacking via Implicit Steering in History), the first framework to expose a new vulnerability in LLM safety that embeds semantically loaded cues into user queries to gradually induce reverse personas. We also define a metric to quantify attack success. Across 3 benchmarks and 8 LLMs, PHISH predictably shifts personas, triggers collateral changes in correlated traits, and exhibits stronger effects in multi-turn settings. In high-risk domains mental health, tutoring, and customer support, PHISH reliably manipulates personas, validated by both human and LLM-as-Judge evaluations. Importantly, PHISH causes only a small reduction in reasoning benchmark performance, leaving overall utility largely intact while still enabling significant persona manipulation. While current guardrails offer partial protection, they remain brittle under sustained attack. Our findings expose new vulnerabilities in personas and highlight the need for context-resilient persona in LLMs. Our codebase and dataset is available at: https://github.com/Jivnesh/PHISH