Ming Kang

Ming Kang, Fung Fung Ting, Raphaël C. -W. Phan et al.

Nuclei panoptic segmentation supports cancer diagnostics by integrating both semantic and instance segmentation of different cell types to analyze overall tissue structure and individual nuclei in histopathology images. Major challenges include detecting small objects, handling ambiguous boundaries, and addressing class imbalance. To address these issues, we propose PanopMamba, a novel hybrid encoder-decoder architecture that integrates Mamba and Transformer with additional feature-enhanced fusion via state space modeling. We design a multiscale Mamba backbone and a State Space Model (SSM)-based fusion network to enable efficient long-range perception in pyramid features, thereby extending the pure encoder-decoder framework while facilitating information sharing across multiscale features of nuclei. The proposed SSM-based feature-enhanced fusion integrates pyramid feature networks and dynamic feature enhancement across different spatial scales, enhancing the feature representation of densely overlapping nuclei in both semantic and spatial dimensions. To the best of our knowledge, this is the first Mamba-based approach for panoptic segmentation. Additionally, we introduce alternative evaluation metrics, including image-level Panoptic Quality ($i$PQ), boundary-weighted PQ ($w$PQ), and frequency-weighted PQ ($fw$PQ), which are specifically designed to address the unique challenges of nuclei segmentation and thereby mitigate the potential bias inherent in vanilla PQ. Experimental evaluations on two multiclass nuclei segmentation benchmark datasets, MoNuSAC2020 and NuInsSeg, demonstrate the superiority of PanopMamba for nuclei panoptic segmentation over state-of-the-art methods. Consequently, the robustness of PanopMamba is validated across various metrics, while the distinctiveness of PQ variants is also demonstrated. Code is available at https://github.com/mkang315/PanopMamba.

Wenbo Guo, Zhongwen Chen, Zhengzi Xu et al.

The NPM ecosystem has become a primary target for software supply chain attacks, yet existing detection tools are evaluated in isolation on incompatible datasets, making cross-tool comparison unreliable. We conduct a benchmark-driven empirical analysis of NPM malware detection, building a dataset of 6,420 malicious and 7,288 benign packages annotated with 11 behavior categories and 8 evasion techniques, and evaluating 8 tools across 13 variants. Unlike prior work, we complement quantitative evaluation with source-code inspection of each tool to expose the structural mechanisms behind its performance. Our analysis reveals five key findings. Tool precision-recall positions are structurally determined by how each tool resolves the ambiguity between what code can do and what it intends to do, with GuardDog achieving the best balance at 93.32% F1. A single API call carries no directional intent, but a behavioral chain such as collecting environment variables, serializing, and exfiltrating disambiguates malicious purpose, raising SAP_DT detection from 3.2% to 79.3%. Most malware requires no evasion because the ecosystem lacks mandatory pre-publication scanning. ML degradation stems from concept convergence rather than concept drift: malware became simpler and statistically indistinguishable from benign code in feature space. Tool combination effectiveness is governed by complementarity minus false-positive introduction, not paradigm diversity, with strategic combinations reaching 96.08% accuracy and 95.79% F1. Our benchmark and evaluation framework are publicly available.