Lang Qin

Weiwei Wu, Yueyang Li, Yuhu Shi et al.

Cross-subject EEG-based emotion recognition (EER) remains challenging due to strong inter-subject variability, which induces substantial distribution shifts in EEG signals, as well as the high complexity of emotion-related neural representations in both spatial organization and temporal evolution. Existing approaches typically improve spatial modeling, temporal modeling, or generalization strategies in isolation, which limits their ability to align representations across subjects while capturing multi-scale dynamics and suppressing subject-specific bias within a unified framework. To address these gaps, we propose a Region-aware Spatiotemporal Modeling framework with Collaborative Domain Generalization (RSM-CoDG) for cross-subject EEG emotion recognition. RSM-CoDG incorporates neuroscience priors derived from functional brain region partitioning to construct region-level spatial representations, thereby improving cross-subject comparability. It also employs multi-scale temporal modeling to characterize the dynamic evolution of emotion-evoked neural activity. In addition, the framework employs a collaborative domain generalization strategy, incorporating multidimensional constraints to reduce subject-specific bias in a fully unseen target subject setting, which enhances the generalization to unknown individuals. Extensive experimental results on SEED series datasets demonstrate that RSM-CoDG consistently outperforms existing competing methods, providing an effective approach for improving robustness. The source code is available at https://github.com/RyanLi-X/RSM-CoDG.

Lang Qin, Rui Yan, Huajin Tang

In recent years, spiking neural networks (SNNs) have been used in reinforcement learning (RL) due to their low power consumption and event-driven features. However, spiking reinforcement learning (SRL), which suffers from fixed coding methods, still faces the problems of high latency and poor versatility. In this paper, we use learnable matrix multiplication to encode and decode spikes, improving the flexibility of the coders and thus reducing latency. Meanwhile, we train the SNNs using the direct training method and use two different structures for online and offline RL algorithms, which gives our model a wider range of applications. Extensive experiments have revealed that our method achieves optimal performance with ultra-low latency (as low as 0.8% of other SRL methods) and excellent energy efficiency (up to 5X the DNNs) in different algorithms and different environments.

Qingyuan Zeng, Ziyang Chen, Pengxiang Cai et al.

Biomedical discovery often requires connecting broad biomedical knowledge with specific experimental or clinical data. Background knowledge suggests relevant mechanisms but is usually too general to map directly onto dataset variables, while data-driven patterns can be dataset-specific and hard to interpret mechanistically. We study this missing link as knowledge contextualization: transforming broad biomedical knowledge into evidence-supported, scenario-grounded propositions that domain experts can inspect, replay, and validate. We propose SCENE, a bi-level multi-agent framework that treats knowledge contextualization as iterative search. The upper level converts broad knowledge into search directions and grounds them in the dataset schema. The lower level executes these directions through multi-objective optimization to identify concrete propositions that balance evidential strength and data support. Feedback between the two levels progressively refines the search. We evaluate SCENE in two settings: discovering patient subgroups with heterogeneous treatment benefits in clinical trial scenarios, and identifying context-specific biological responses in LINCS L1000 studies. In clinical trials, SCENE discovers specific, well-supported subgroups and outperforms existing baselines. In L1000 studies, SCENE identifies perturbational contexts with strong target-response matching and high positive rates. These results show that SCENE bridges broad knowledge and scenario-specific evidence, producing traceable, inspectable hypotheses for follow-up validation.

Qingyuan Zeng, Pengxiang Cai, Zixin Guan et al.

Designing a single molecule that modulates two targets is a promising strategy for polypharmacology, but it remains substantially harder than standard single-target generation because one candidate must satisfy two binding requirements while preserving drug-likeness and synthesizability. Existing dual-target generative methods typically introduce dual-target capability by either retraining the generator or intervening in the diffusion process during sampling. The former can be costly and difficult to stabilize when dual-target supervision is sparse, while the latter may be sensitive to denoising-time target balancing and competing update directions. These limitations motivate a generator-preserving alternative that keeps the pretrained prior intact: can dual-target candidates instead be recovered from the input space of a frozen single-target diffusion model, without modifying its parameters or denoising dynamics? We formulate this task as a constrained multi-objective optimization problem and propose REUSE, a hierarchical evolutionary input-space search framework that combines pair-conditioned exploration with structured multi-stage selection to enforce dual-target affinity, chemical quality, and diversity. Experiments show that, compared with methods that modify the diffusion process, REUSE consistently improves dual-target affinity and balance, achieving a 20.9-percentage-point gain in Dual High Affinity over the strongest prior baseline while maintaining competitive molecular quality.

Guoxi Zhang, Jiawei Chen, Tianzhuo Yang et al.

As Large Language Models (LLMs) expand in capability and application scope, their trustworthiness becomes critical. A vital risk is intrinsic deception, wherein models strategically mislead users to achieve their own objectives. Existing alignment approaches based on chain-of-thought (CoT) monitoring supervise explicit reasoning traces. However, under optimization pressure, models are incentivized to conceal deceptive reasoning, rendering semantic supervision fundamentally unreliable. Grounded in cognitive psychology, we hypothesize that a deceptive LLM maintains a stable internal belief in its CoT while its external response remains fragile under perturbation. We term this phenomenon stability asymmetry and quantify it by measuring the contrast between internal CoT stability and external response stability under perturbation. Building on this structural signature, we propose the Stability Asymmetry Regularization (SAR), a novel alignment objective that penalizes this distributional asymmetry during reinforcement learning. Unlike CoT monitoring, SAR targets the statistical structure of model outputs, rendering it robust to semantic concealment. Extensive experiments confirm that stability asymmetry reliably identifies deceptive behavior, and that SAR effectively suppresses intrinsic deception without degrading general model capability.

Lang Qin, Yao Zhang, Hongru Liang et al.

Accurate knowledge selection is critical in knowledge-grounded dialogue systems. Towards a closer look at it, we offer a novel perspective to organize existing literature, i.e., knowledge selection coupled with, after, and before generation. We focus on the third under-explored category of study, which can not only select knowledge accurately in advance, but has the advantage to reduce the learning, adjustment, and interpretation burden of subsequent response generation models, especially LLMs. We propose GATE, a generator-agnostic knowledge selection method, to prepare knowledge for subsequent response generation models by selecting context-related knowledge among different knowledge structures and variable knowledge requirements. Experimental results demonstrate the superiority of GATE, and indicate that knowledge selection before generation is a lightweight yet effective way to facilitate LLMs (e.g., ChatGPT) to generate more informative responses.

Shan Ding, Yongfu Tian, Lang Qin et al.

Driven by rapid advances in artificial intelligence and modern GPU computing capabilities, deep learning methods based on the optimization paradigm have provided new pathways to solve spatiotemporal physical problems, whose mathematical core lies in solving partial differential equations (PDEs). As an emerging class of function-space learning methods, neural operators (NOs) have exhibited great potential in efficient PDE solving. However, existing mainstream neural operator frameworks suffer from critical bottlenecks when modeling time-dependent PDEs over long time horizons, including accuracy degradation, insufficient stability, high training costs, and excessive memory consumption, which severely limit their practical deployment. To address these challenges in long-time prediction with neural operators, we propose a novel spatiotemporally decoupled physics-informed neural operator architecture, termed the physics-informed Stone-Weierstrass neural operator (PI-SWNO). The design is theoretically grounded in the decoupling paradigm combining time-invariant spatial basis functions with time-varying evolution coefficients, as well as the Stone-Weierstrass approximation theorem. By encoding spatial and temporal information via two separate subnetworks, the framework structurally mitigates the accumulation of errors over extended time intervals. Furthermore, we introduce a time-marching batch-wise sampling strategy to resolve the memory bottleneck of full-range modeling over extended time spans, ensuring continuity and convergence of full-time-domain solutions.

Ziming Wang, Ziling Wang, Huaning Li et al.

Event cameras, with their high dynamic range and temporal resolution, are ideally suited for object detection, especially under scenarios with motion blur and challenging lighting conditions. However, while most existing approaches prioritize optimizing spatiotemporal representations with advanced detection backbones and early aggregation functions, the crucial issue of adaptive event sampling remains largely unaddressed. Spiking Neural Networks (SNNs), which operate on an event-driven paradigm through sparse spike communication, emerge as a natural fit for addressing this challenge. In this study, we discover that the neural dynamics of spiking neurons align closely with the behavior of an ideal temporal event sampler. Motivated by this insight, we propose a novel adaptive sampling module that leverages recurrent convolutional SNNs enhanced with temporal memory, facilitating a fully end-to-end learnable framework for event-based detection. Additionally, we introduce Residual Potential Dropout (RPD) and Spike-Aware Training (SAT) to regulate potential distribution and address performance degradation encountered in spike-based sampling modules. Empirical evaluation on neuromorphic detection datasets demonstrates that our approach outperforms existing state-of-the-art spike-based methods with significantly fewer parameters and time steps. For instance, our method yields a 4.4\% mAP improvement on the Gen1 dataset, while requiring 38\% fewer parameters and only three time steps. Moreover, the applicability and effectiveness of our adaptive sampling methodology extend beyond SNNs, as demonstrated through further validation on conventional non-spiking models. Code is available at https://github.com/Windere/EAS-SNN.

Lang Qin, Ziming Wang, Runhao Jiang et al.

Spiking neural networks (SNNs) are widely applied in various fields due to their energy-efficient and fast-inference capabilities. Applying SNNs to reinforcement learning (RL) can significantly reduce the computational resource requirements for agents and improve the algorithm's performance under resource-constrained conditions. However, in current spiking reinforcement learning (SRL) algorithms, the simulation results of multiple time steps can only correspond to a single-step decision in RL. This is quite different from the real temporal dynamics in the brain and also fails to fully exploit the capacity of SNNs to process temporal data. In order to address this temporal mismatch issue and further take advantage of the inherent temporal dynamics of spiking neurons, we propose a novel temporal alignment paradigm (TAP) that leverages the single-step update of spiking neurons to accumulate historical state information in RL and introduces gated units to enhance the memory capacity of spiking neurons. Experimental results show that our method can solve partially observable Markov decision processes (POMDPs) and multi-agent cooperation problems with similar performance as recurrent neural networks (RNNs) but with about 50% power consumption.

Lang Qin, Zijian Gan, Xu Cao et al.

Computational drug repurposing for rare diseases is especially challenging when no prior associations exist between drugs and target diseases. Therefore, knowledge graph completion and message-passing GNNs have little reliable signal to learn and propagate, resulting in poor performance. We present RareAgent, a self-evolving multi-agent system that reframes this task from passive pattern recognition to active evidence-seeking reasoning. RareAgent organizes task-specific adversarial debates in which agents dynamically construct evidence graphs from diverse perspectives to support, refute, or entail hypotheses. The reasoning strategies are analyzed post hoc in a self-evolutionary loop, producing textual feedback that refines agent policies, while successful reasoning paths are distilled into transferable heuristics to accelerate future investigations. Comprehensive evaluations reveal that RareAgent improves the indication AUPRC by 18.1% over reasoning baselines and provides a transparent reasoning chain consistent with clinical evidence.

Xiuwen Wu, Hao Wang, Zhiang Yan et al.

Effective and safe human-machine collaboration requires the regulated and meaningful exchange of emotions between humans and artificial intelligence (AI). Current AI systems based on large language models (LLMs) can provide feedback that makes people feel heard. Yet it remains unclear whether LLMs represent emotion in language as humans do, or whether and how the emotional tone of their output can be controlled. We assess human-AI emotional alignment across linguistic-cultural groups and model-families, using interpretable LLM features translated from concept-sets for over twenty nuanced emotion categories (including six basic emotions). Our analyses reveal that LLM-derived emotion spaces are structurally congruent with human perception, underpinned by the fundamental affective dimensions of valence and arousal. Furthermore, these emotion-related features also accurately predict large-scale behavioural data on word ratings along these two core dimensions, reflecting both universal and language-specific patterns. Finally, by leveraging steering vectors derived solely from human-centric emotion concepts, we show that model expressions can be stably and naturally modulated across distinct emotion categories, which provides causal evidence that human emotion concepts can be used to systematically induce LLMs to produce corresponding affective states when conveying content. These findings suggest AI not only shares emotional representations with humans but its affective outputs can be precisely guided using psychologically grounded emotion concepts.

Shaoyu Pei, Renxiong Wu, Hao Zheng et al.

Skin, the primary regulator of heat exchange, relies on sweat glands for thermoregulation. Alterations in sweat gland morphology play a crucial role in various pathological conditions and clinical diagnoses. Current methods for observing sweat gland morphology are limited by their two-dimensional, in vitro, and destructive nature, underscoring the urgent need for real-time, non-invasive, quantifiable technologies. We proposed a novel three-dimensional (3D) transformer-based multi-object segmentation framework, integrating a sliding window approach, joint spatial-channel attention mechanism, and architectural heterogeneity between shallow and deep layers. Our proposed network enables precise 3D sweat gland segmentation from skin volume data captured by optical coherence tomography (OCT). For the first time, subtle variations of sweat gland 3D morphology in response to temperature changes, have been visualized and quantified. Our approach establishes a benchmark for normal sweat gland morphology and provides a real-time, non-invasive tool for quantifying 3D structural parameters. This enables the study of individual variability and pathological changes in sweat gland structure, advancing dermatological research and clinical applications, including thermoregulation and bromhidrosis treatment.